Chemical Constituents of Gentianaceae XIX: CNS-Depressant Effects of Swertiamarin

Bhattacharya, Sujit; Reddy, P. M.; Ghosal, Shibnath; Singh, Asmita; Sharma, Priyanka

doi:10.1002/jps.2600651037

Cited by 76 publications

(26 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The major phytochemicals identified in CFSc were xanthones, terpenoids, and polyphenols. These findings are well in accordance with previous reports where ethanolic extracts of S. chirata have shown the presence of these phytochemicals in significant amounts 16,20 . Among these phytochemicals the anti-tumor activity of xanthones is well known, which include cell cycle arrest, suppression of tumor cell proliferation, induction of apoptosis and differentiation, reduction of inflammation, and inhibition of adhesion, invasion, and metastasis [21][22][23] .…”

Section: Resultssupporting

confidence: 94%

GC-MS/MS Based Identification of Bioactive Principles of Chloroform fraction of Swertia Chirayatia (Chirata)

Khan¹,

Kaleem²,

Khan³

et al. 2016

Orient. J. Chem

View full text Add to dashboard Cite

The aim of this study is to characterize the chemical composition, in vitro antioxidant and anticancer activity of chloroform fraction of Swertia chirata L. (Family Gentianaceae). GC-MS analysis of chloroform fraction of S. chirata (CFSc) identified twenty-five compounds belonging to different chemical class. Among these important classes of compounds were tri-terpenoids, phenol, acids, and fatty acids. Phytochemical analysis of CFSc was well supported by its Total Phenolic Content and antioxidant activity with in vitro anticancer activity which was evaluated by MTT assay It was also seen that CFSc exhibited anti-proliferative activity against human breast cancer cell lines (MDA-MB-231 and MCF-7). In conclusion; Study revealed an extensive biochemical profile of CFSc as well its potential as a pharmacological agent with respect of its antioxidant and anti-cancer property. More safety and toxicological studies are needed to be addressed to ensure the use of CFSc for medicinal purposes.

show abstract

Section: Resultssupporting

confidence: 94%

GC-MS/MS Based Identification of Bioactive Principles of Chloroform fraction of Swertia Chirayatia (Chirata)

Khan¹,

Kaleem²,

Khan³

et al. 2016

Orient. J. Chem

View full text Add to dashboard Cite

show abstract

“…Some specific activities have been reported for iridoids from Gentianaceae. Swertiamarin (6) should have anticholinergic properties (Bhattacharya et al, 1976;Liang et al, 1982;Yamahara et al, 1991). For sweroside (5) and gentiopicroside (7) hepatoprotective activities have been reported (Zhou, 1991;Kondo et al, 1994), and both compounds are being used as antihepatitis drugs.…”

Section: Saccifolieaementioning

confidence: 99%

Chemotaxonomy and pharmacology of Gentianaceae

Jensen

Schripsema²

2001

Gentianaceae

View full text Add to dashboard Cite

“…(Magora et al, 2003) and other Swertia davidi Franch, has been an important traditional drug in China for many years. Swertiamarin has a wide range of therapeutic effects such as anticholinergic action (Yamahara et al, 1991), inhibition of the growth of Bacillus cereus, Bacillus subtilis, Citrobacter freundii, Escherichia coli, Proteus mirabilis and Serritia marcescens (Kumarasamy et al, 2003), depressant action and inhibition of human DNA lipase and CNS-depressant effects (Bhattacharya et al, 1976). When cultured with Aspergillus niger, swertiamarin is rapidly transformed into two metabolites, (5Z)- 5-ethylidene-8-hydroxy-3,4,5,6,7,8-hexahydro-1H-pyrano[3,4-c]pyridin-1-one (M 1 ) and erythrocentaurin.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of swertiamarin and its metabolites (5Z)‐5‐ethylidene‐8‐hydroxy‐3,4,5,6,7,8‐hexahydro‐1H‐pyrano[3,4‐c]pyridin‐1‐one and erythrocentaurin in broth of Aspergillus niger by HPLC

Chang

Zhao

Liu

2007

Biomedical Chromatography

View full text Add to dashboard Cite

When cultivated with Aspergillus niger, swertiamarin, an important drug, is rapidly transformed into erythrocentaurin and (5Z)-5-ethylidene-8-hydroxy-3,4,5,6,7,8-hexahydro-1H-pyrano[3,4-c]pyridin-1-one (M(1)), a new compound with high anti-inflammatory activity. A simple and rapid HPLC method for simultaneous determination of swertiamarin and its two metabolites in broth of A. niger is described. The chromatographic separation was achieved on a C(18) ODS column (250 x 4.6 mm i.d.) by gradient elution with 0.04% formic acid in water and 0.04% formic acid in acetonitrile as the gradient mixtures. The flow rate was 1 mL/min, the detection wavelength was 237 nm and the column temperature was kept at 30 degrees C. The retention times of swertiamarin, erythrocentaurin and M(1) were 14.6, 16.8 and 24.8 min, respectively. The mean absolute recoveries of three analysts were over 96%. Quantification limits were 0.02 microg/mL for swertiamarin and 0.05 microg/mL for both of the two metabolites. The method was applied for the quantification of swertiamarin and its two metabolites during the fermentation process and the evaluation of the bioavailabilities in the Caco-2 monolayer.

show abstract

Chemical Constituents of Gentianaceae XIX: CNS-Depressant Effects of Swertiamarin

Cited by 76 publications

References 4 publications

GC-MS/MS Based Identification of Bioactive Principles of Chloroform fraction of Swertia Chirayatia (Chirata)

GC-MS/MS Based Identification of Bioactive Principles of Chloroform fraction of Swertia Chirayatia (Chirata)

Chemotaxonomy and pharmacology of Gentianaceae

Simultaneous determination of swertiamarin and its metabolites (5Z)‐5‐ethylidene‐8‐hydroxy‐3,4,5,6,7,8‐hexahydro‐1H‐pyrano[3,4‐c]pyridin‐1‐one and erythrocentaurin in broth of Aspergillus niger by HPLC

Contact Info

Product

Resources

About