Chemical Constituents of a Marine Fungus, <i>Arthrinium sacchari</i>

Tsukada, Mariko; Fukai, Miyuki; Miki, Kazuhiko; Shiraishi, Takeshi; Suzuki, Toshihiro; Nishio, Kazuto; Sugita, Takashi; Ishino, Masahiro; Kinoshita, Kaoru; Takahashi, Kunio; Shiro, Motoo; Koyama, Kiyotaka

doi:10.1021/np200108h

Cited by 51 publications

(40 citation statements)

References 11 publications

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“…sacchari could help Termitomyces decompose lignocellulosic material, thus stimulating its growth by 58.6% (Sawhasan, Worapong, Flegel & Vinijsanun, 2012). Concentration (mg/mL) (Tsukada et al, 2011). Therefore, the certain concentration of SCS that exhibited selective bactericidal activity could be used in specific medical and agricultural observed in WCS-and SCS-treated A. sacchari (Fig.…”

Section: Antibacterial Activity Of Wcs and Scs Against E Coli And Smentioning

confidence: 99%

Synthesis, characterization, and antimicrobial activities of sulfonated chitosan

Sun

Shi

Wang

et al. 2017

Carbohydrate Polymers

121

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Sulfonated chitosan (SCS) was prepared via a facile chemical procedure by using 1,3-propane sultone attached to the backbone of chitosan. The resulting chitosan derivative was characterized by Fourier transform-infrared spectroscopy, nuclear magnetic resonance spectroscopy, gel permeation chromatography, elemental analysis, and thermo gravimetric analysis. The antibacterial experiments demonstrated that SCS exhibited higher antibacterial activities against Escherichia coli and Staphylococcus aureus with the minimum inhibitory concentration (MIC) of 0.13mg/mL and 2.00mg/mL than those of water-soluble chitosan (WCS) with MIC of 0.50mg/mL and 4.00mg/mL. However, different antifungal activities of SCS against Arthrinium sacchari (MIC, 64.00mg/mL) and Botrytis cinerea (MIC, 0.25mg/mL) were observed. Scanning electron microscopy revealed that WCS and SCS could damage and deform the structure of fungal hyphae with different action modes. It is worth mentioning that SCS exhibited selective antifungal activity, which was an important parameter to control its biological performance in many fields.

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Section: Antibacterial Activity Of Wcs and Scs Against E Coli And Smentioning

confidence: 99%

Synthesis, characterization, and antimicrobial activities of sulfonated chitosan

Sun

Shi

Wang

et al. 2017

Carbohydrate Polymers

121

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“…Interestingly, it had a higher activity towards MCF7 and A549 with IC 50 s 8.0 and 5.8 µM, respectively[89]. The new isocoumarin, 108 isolated from Arthrinium sacchari displayed a weak cytotoxic effect towards HUVECs and HUAECs (IC 50 70.8 and 277.1 µM, respectively), compared to Ki8751 (IC 50 s 1.0-2.0 µM) using MTT assay[90]. Compound 35 did not have a cytotoxic effect against MRC-5 and AGS cell lines[91].…”

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confidence: 99%

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

et al. 2020

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Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi.

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“…Because the absolute stereochemistry of 1 remained unknown, we attempted a single crystal formation of the compound for a low‐temperature (100 K) X‐ray diffraction with copper K α emission, which determined as desired its (1 S ,4 S ,9 S ,10 S ,13 R )‐configuration in an unambiguous manner (Figure S1 in the Supporting Information). According to the 1 H and 13 C NMR spectroscopic data and 2D NMR experiments, compounds 2 – 4 were identified as libertellenones C ( 2 )10 and E ( 3 )11 and myrocin B ( 4 ),12 respectively.…”

Section: Resultsmentioning

confidence: 99%

Immunosuppressive Diterpenes from Phomopsis sp. S12

et al. 2014

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New immunosuppressants are needed to assist therapeutic efforts to manage immunological diseases. Along with known compounds 1–4, new diterpenes myrocin E (5), libertellenone J (6) and libertellenone K (7) were isolated from the culture of Phomopsis sp. S12, from the apparently normal seed of Illigera rhodantha (Hernandiaceae). The structures were elucidated by a combination of spectroscopic and computational approaches, in conjunction with the low‐temperature (100 K) single‐crystal X‐ray diffraction with copper Kα radiation. Libertellenone J (6) was shown to reduce significantly the production of NO, IL‐1β, IL‐6 and TNF‐α with an IC50 range of 2.2–10.2 μM, and to decrease the levels of iNOS, IL‐1β, IL‐6 and TNF‐α mRNA expression in lipopolysaccharide‐activated macrophages with IC50 values of 3.5–15.2 μM. These significant results may inspire the development of new immunosuppressive agents.

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Chemical Constituents of a Marine Fungus, Arthrinium sacchari

Cited by 51 publications

References 11 publications

Synthesis, characterization, and antimicrobial activities of sulfonated chitosan

Synthesis, characterization, and antimicrobial activities of sulfonated chitosan

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

Immunosuppressive Diterpenes from Phomopsis sp. S12

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