Chemical Constituents Isolated from the Root Bark of Cudrania tricuspidata and Their Potential Neuroprotective Effects

Abstract

Seventy-five compounds, including 21 new compounds (1-21), were isolated from the root bark of Cudrania tricuspidata. The structures of the isolated compounds were elucidated by interpretation of their spectroscopic data. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death, and nine compounds had activities with EC50 values of 1.9-30.2 μM. The 75 isolated compounds along with 34 previously reported xanthones were tested also for neuroprotective effects against the 1-methyl-4-phenylpyridinium ion (MPP(+)) and oxygen glucose deprivation (OGD)-induced cell death. Three compounds were active against MPP(+)-induced cell death with EC50 values of 0.2-10.3 μM, and 23 compounds were active in the OGD model with EC50 values of 2.9-35.5 μM.

Quantitative Analysis, Extraction Optimization, and Biological Evaluation of Cudrania tricuspidata Leaf and Fruit Extracts

“…The roots and leaves of this perennial herb contain pharmaceutically active substances with anti-cancer activity, antioxidant activity, and blood glucose-lowering effects. The root bark has demonstrated anti-atherosclerotic [ 2 ], anti-inflammatory [ 3 ], antioxidant [ 4 ], neuroprotective [ 5 ], hepatoprotective [ 6 ], and cytotoxic activity [ 7 ]. In addition, C. tricuspidata fruit is reported to have neuroprotective [ 8 ], anti-inflammatory [ 9 , 10 ], pancreatic lipase inhibitory [ 11 ], mast cell activating [ 12 ], monoamine oxidase inhibitory [ 13 ], and anti-obesity effects [ 14 ].…”

Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

“…1). The stereochemistry at C-12′ and C-13′ was deduced as trans -form by the coupling constant ( J H-12′,H-13′  = 4.4 Hz) and comparing with that of 16-hydroxycudratrixanthone Q [11]. In order to determine the stereochemistry of 1 , the two possible configurations, 2 S *,12′ S* ,13′ S* - 1 ( 1a ) and 2 S *,12′ R* ,13′ R* - 1 ( 1b ), were applied to quantum computation at the B3LYP/6-311 + g(d,2p) level for the 13 C NMR data.…”

Xanthones and Cancer: from Natural Sources to Mechanisms of Action

“…Root barks no [39] 1-Hydroxy-3,6,7-tri-O,O,O-prenylxanthone Garcinia nobilis Stem barks no [29] 1-Hydroxy-4,5,6,7,8-pentamethoxyxanthone…”

“…Root barks no [39] 8-Ethoxy-8,8a-dihydrobractatin Garcinia bracteata Leaves yes [38] 8-Hydroxy-1,4,5,6-tetramethoxy-2,3-methylenedioxyxanthone Securidaca longepedunculata…”

“…Root barks no [39] Cudratrixanthone Q Cudrania tricuspidata Root barks no [39] Cudratrixanthone R Cudrania tricuspidata Root barks no [39] Cudratrixanthone S Cudrania tricuspidata Root barks no [39] Cudratrixanthone T…”