Chemical constituents from Valeriana officinalis L. var. Iatifolia Miq. and their chemotaxonomic significance

Wang, Shuliang; Zeng, Yan-Rong; Li, Yanan; Li, He; Hu, Zhan-Xing; Huang, Liejun; Gu, Wei; Yuan, Chun‐Mao; Hao, Xiaojiang

doi:10.1016/j.bse.2020.104041

Cited by 9 publications

(6 citation statements)

References 40 publications

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“…Except for the constituents mentioned earlier, some other compounds were also isolated, namely, caffeic acid, p -coumaric acid, gallic acid ( Jugran et al, 2019 ), isoferulic acid ( Wang S. J. et al, 2014 ), decursitin A, decursitin B, decursidin, 3′( S )-acetoxy-4′( R )-angeloyloxy-3′,4′-dihydroxanthyletin, dibutyl phthalate, phenanthrene, hydroxybenzoic acid, chlorogenic acid, benzoic acid, oleic acid, (-)-bornyl caffeate, tannin ( Wang et al, 2009a , Wang et al, 2014 S. J. ; Jugran et al, 2019 ; Wang S. L. et al, 2020 ), zansiumloside A ( Wan et al, 2016 ), linoleic acid, palmitic acid, nonadecyl alcohol, β -carotene ( Wang et al, 2009a , Wang et al, 2014 S. J. ; Jugran et al, 2019 ; Wang S. L. et al, 2020 ), epoxylathyrol 3,5-dibutyrate ( Thies, 1968a and β -sitosterol ( Wang S. L. et al, 2020 ).…”

Section: Phytochemistrymentioning

confidence: 99%

“…; Jugran et al, 2019 ; Wang S. L. et al, 2020 ), zansiumloside A ( Wan et al, 2016 ), linoleic acid, palmitic acid, nonadecyl alcohol, β -carotene ( Wang et al, 2009a , Wang et al, 2014 S. J. ; Jugran et al, 2019 ; Wang S. L. et al, 2020 ), epoxylathyrol 3,5-dibutyrate ( Thies, 1968a and β -sitosterol ( Wang S. L. et al, 2020 ).…”

Section: Phytochemistrymentioning

confidence: 99%

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The potential of Valeriana as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry

Wang

et al. 2022

Front. Pharmacol.

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Valeriana plants are members of the Caprifoliaceae family, which include more than 200 species worldwide. We summarized previous reports on traditional clinical applications, bioactivities, and phytochemistry of Valeriana by searching electronic databases of Science Direct, Web of Science, PubMed, and some books. Some Valeriana species have been used as traditional medicines, demonstrating calming fright and tranquilizing mind, promoting Qi and blood, activating blood circulation and regulating menstruation, dispelling wind and eliminating dampness, regulating Qi-flowing to relieve pain, and promoting digestion and checking diarrhea, and treating diseases of the nervous, cardiovascular, and digestive systems, inflammation, gynecology, and others. Pharmacology studies revealed the effects of Valeriana, including sedative, hypnotic, antispasmodic, analgesic, antidepressant, anxiolytic, anticonvulsant, antiepileptic, neuroprotective, antibacterial, antiviral, cytotoxic, and antitumor effects as well as cardiovascular and cerebrovascular system improvements. More than 800 compounds have been isolated or identified from Valeriana, including iridoids, lignans, flavonoids, sesquiterpenoids, alkaloids, and essential oils. Constituents with neuroprotective, anti-inflammatory, cytotoxic, and sedative activities were also identified. However, at present, the developed drugs from Valeriana are far from sufficient. We further discussed the pharmacological effects, effective constituents, and mechanisms directly related to the traditional clinical applications of Valeriana, revealing that only several species and their essential oils were well developed to treat insomnia. To effectively promote the utilization of resources, more Valeriana species as well as their different medicinal parts should be the focus of future related studies. Clinical studies should be performed based on the traditional efficacies of Valeriana to facilitate their use in treating diseases of nervous, cardiovascular, and digestive systems, inflammation, and gynecology. Future studies should also focus on developing effective fractions or active compounds of Valeriana into new drugs to treat diseases associated with neurodegeneration, cardiovascular, and cerebrovascular, inflammation and tumors. Our review will promote the development and utilization of potential drugs in Valeriana and avoid wasting their medicinal resources.

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Section: Phytochemistrymentioning

confidence: 99%

Section: Phytochemistrymentioning

confidence: 99%

The potential of Valeriana as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry

Wang

et al. 2022

Front. Pharmacol.

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“…[19] Previous phytochemical investigations on the genus have resulted the isolation of various secondary metabolites including mainly iridoid, sesquiterpenes, and lignans as well as flavonoids. [15,20] The extract prepared from the underground parts of several Valeriana species as well as some isolated compounds were reported to show a variety of pharmacological activities such as antidepressant, anxiolytic, cytotoxic, antitumor, neuroprotective, anticonvulsant, anti-inflammatory and antibacterial activities. [20 -27] Besides being well-known for their sedative and sleep enhancing properties, Valeriana species have also received considerable attention recently due to their potent cytotoxic and antitumor secondary metabolites, mostly for their non-glycosidic iridoid contents.…”

Section: Introductionmentioning

confidence: 99%

“…The genus Valeriana of the Caprifoliaceae (formerly Valerianaceae) family consists of more than 200 species worldwide, distributed especially in Europe, North America and Asia [14–15] . Some species of the genus, mainly V. officinalis and V. jatamansi have been used in traditional medicines for their sedative and anxiolytic properties since ancient times [14,16] .…”

Section: Introductionmentioning

confidence: 99%

“…The root infusion of V. alliariifolia is traditionally utilized as sedative and spasmolytic in East Anatolia region of Turkey [19] . Previous phytochemical investigations on the genus have resulted the isolation of various secondary metabolites including mainly iridoid, sesquiterpenes, and lignans as well as flavonoids [15,20] . The extract prepared from the underground parts of several Valeriana species as well as some isolated compounds were reported to show a variety of pharmacological activities such as antidepressant, anxiolytic, cytotoxic, antitumor, neuroprotective, anticonvulsant, anti‐inflammatory and antibacterial activities [20–27] .…”

Section: Introductionmentioning

confidence: 99%

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Activity‐Guided Isolation of Cytotoxic Non‐Glycosidic Ester Iridoids from Valeriana alliariifolia Adams and Unravelling Their Cell Death Mechanisms

Erdoğan

Aru

Tayğun

et al. 2022

Chemistry & Biodiversity

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The aim of this study was to isolate the cytotoxic compounds from V. alliariifolia via activity-guided isolation and to determine the mechanism of actions of the most potent ones. The crude EtOH extract as well as CHCl 3 and AcOEt subextracts demonstrated remarkable cytotoxic activities against A549, MCF7, HGC27 and PC3 cancer cells. Sequential chromatographic separations on active subextracts yielded 14 secondary metabolites, including 11 iridoids (1 -11) most of which belong to non-glycosidic ester iridoids, two phenylpropanoids (12 and 13) and one lignan ( 14). The chemical structures of purified compounds were elucidated by NMR and MS analysis. Among the isolates, 7-deisovaleroylvaltrate (3) was isolated for the first time as a natural product. According to the cytotoxic assay compounds, 2, 4-6 and 8 were found to be the potent cytotoxic compounds (IC 50 < 10 μM) against at least one of the tested cancer cell lines. Thus, 2, 4-6 and 8 were investigated for their effects on apoptotic, necrotic and autophagic pathways as well as cell cycle progression. They exerted anticancer activities by inducing different cell death mechanisms depending on the cancer cells. The results demonstrated that 2, 4-6 and 8 could be potential anticancer drug leads that deserve further in vivo and clinical studies on the way to discover novel natural compounds with anticancer properties.

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Critical review and mechanistic insights into the health-protective and Immunomodulatory activity of Tiryāq (Theriac) from the purview of Unani medicine

Nikhat,

Fazil

2023

Brain Behavior and Immunity Integrative

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Chemical constituents from Valeriana officinalis L. var. Iatifolia Miq. and their chemotaxonomic significance

Cited by 9 publications

References 40 publications

The potential of Valeriana as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry

The potential of Valeriana as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry

Activity‐Guided Isolation of Cytotoxic Non‐Glycosidic Ester Iridoids from Valeriana alliariifolia Adams and Unravelling Their Cell Death Mechanisms

Critical review and mechanistic insights into the health-protective and Immunomodulatory activity of Tiryāq (Theriac) from the purview of Unani medicine

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