Chemical constituents from Tribulus terrestris and screening of their antioxidant activity

Hammoda, Hala M.; Ghazy, Nabila M.; Harraz, Fathalla M.; Radwan, Mohamed M.; ElSohly, Mahmoud A.; Abdallah, Ingy I

doi:10.1016/j.phytochem.2013.04.005

Cited by 79 publications

(56 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tribulus terrestris L., popularly known by various names such as tribulus, natural viagra, puncture vine, thorn three points, devil's thorn, yellow vine. Bull's head is a plant of Zygophyllaceae family from India but widely distributed in warm regions around the world (Kostova and Dinchev 2005;Hammoda et al 2013). In traditional Chinese and Indian medicine, the fruit is used in the treatment of infertility, impotence, erectile dysfunction and low libido (Gauthaman et al 2002;Gauthaman and Ganesan 2008;Singh and Gupta 2011).…”

Section: Introductionmentioning

confidence: 99%

Sperm Quality and Testicular Histomorphometry of Wistar Rats Supplemented with Extract and Fractions of Fruit of Tribulus terrestris L.

Oliveira

Félix

Pereira

et al. 2015

Braz. arch. biol. technol.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Sperm Quality and Testicular Histomorphometry of Wistar Rats Supplemented with Extract and Fractions of Fruit of Tribulus terrestris L.

Oliveira

Félix

Pereira

et al. 2015

Braz. arch. biol. technol.

View full text Add to dashboard Cite

show abstract

“…These findings prompted the phytochemical investigation of the most active fraction (ethyl acetate) leading to the isolation of two major phenolic compounds (4,5-di-p-ciscoumaroylquinic acid and 4,5-di-p-transcoumaroylquinic acid) showing IC 50 very close to that of ascorbic acid proving their responsibility for the antioxidant effect (Hammoda et al, 2013).…”

Section: Discussionmentioning

confidence: 87%

“…Also, we attempt to understand the cause of the hepatoprotective activity by evaluating the in vivo antioxidant activity and linking the results to the previously examined in vitro DPPH free radical scavenging activity (Hammoda, et al, 2013) in order to determine the main compound(s) responsible for the antioxidant and hepatoprotective effects of the plant. Moreover, acute toxicity study was carried out to ensure the safety of the plant.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective and Antioxidant Activities of Tribulus Terrestris

Harraz¹,

Ghazy²,

Hammoda³

et al. 2015

J. Phys. Pharm. Adv.

View full text Add to dashboard Cite

Tribulus terrestris L. has been used in folk medicine throughout history. The present study examined the acute toxicity of the total ethanolic extract of T. Terrestris followed by investigation of the hepatoprotective activity of the total ethanolic extract and different fractions of the aerial parts of the plant compared to silymarin against carbon tetrachloride-induced hepatic damage in rats. In addition, in vivo antioxidant activity was examined and linked to the previous in vitro DPPH free radical scavenging activity investigation. This study established the plant's safety and the hepatoprotective effect of the total ethanolic extract of the aerial parts of the plant and its different fractions due to significant decrease in CCl 4 -induced rise in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin in rats. Treatment with the ethyl acetate fraction significantly reduced oxidative stress in CCl 4 -intoxicated rats, as evident by a decrease inmalondialdehyde (MDA) content associated with elevation of hepatic reduced glutathione (GSH) content and superoxide dismutase (SOD) activity. Hence, this hepatoprotective effect could be due to the antioxidant activity of the plant which is mainly imparted by the two major di-p-coumaroylquinic acid derivatives isolated from the ethyl acetate fraction.

show abstract

“…In the presence of oxygen, the free radicals attack polyunsaturated fatty acids of the hepatic and renal cell membranes to produce lipid peroxides leading to hepatic and renal injuries. Scavenging the free radicals by antioxidant substances such as vit E, Se and Tribulus flavanoid and polyphenol compounds can inhibit the chain reaction of lipid peroxidation (Hammoda et al, 2013) and protect parenchymal organs such as liver and kidney. The antioxidant activities of herbal flavanoid and polyphenol compounds are well documented in many research works (Abdou et al, 2015;Harraz et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Impacts of <i>Tribulus terrestris</i> Against Ivermectin-Induced Hepato-Renal Toxicity in Rabbit: Pharmacological and Histopathological Study

Ismaiel¹,

Farouk²,

El-Ramady³

et al. 2017

American Journal of Animal and Veterinary Sciences

View full text Add to dashboard Cite

Abstract:The current work aimed to investigate the protective effects of Tribulus terrestris extracts against ivermectin-induced hepatic and renal toxicity in male rabbit. Selenium plus vitamin E was used as a comparative standard drug to evaluate the efficacy of Tribulus terrestris extract on some hematological parameters, kidney and liver enzymes as well as associated histopathological changes. This work was carried out on thirty male New Zealand rabbits for two successive months. Animals were divided into five groups of six rabbits each. The 1st group was designated as the negative control; the 2nd group was subcutaneously injected with ivermectin (IVM) (200µg/kg/month). The 3rd group was treated daily with selenium plus vitamin E (Se + vit E) after IVM injection. The 4th and 5th groups were treated with Tribulus terrestris Ethanol Extract (TTE) and Tribulus Terrestris Ethyl Acetate extract (TTEA) respectively at a dose of 5mg/kg/day after IVM injection. Hematological results showed significant (P<0.05) increases in RBCs, hemoglobin and hematocrit percentage after both TTE and TTEA extracts treatment compared to IVM and Se + vit E groups. There was a significant decrease in AST activity in TTE and Se + vit E treated groups (17.17±0.95 and 16.50±0.76 U/L) and non-significant decreased activity in TTEA group (18.83±0.6 U/L) compared with IVM injected group (21.5±1.31 U/L). Moreover, there were non-significant (P<0.05) changes in both serum creatinine and urea concentrations in IVM, TTE, TTEA and Se + vit E treated groups. Regarding to histo-architectural changes, TTE treated group revealed mild degenerative changes in the renal parenchyma with congested blood vessels, meanwhile, the TTEA treated group revealed few degenerative changes in hepatocytes. This study concluded that, Tribulus terrestris extracts could be used as an effective treatment to ameliorate the ivermectin-induced renal and hepatic toxicity in rabbits.

show abstract

Chemical constituents from Tribulus terrestris and screening of their antioxidant activity

Cited by 79 publications

References 22 publications

Sperm Quality and Testicular Histomorphometry of Wistar Rats Supplemented with Extract and Fractions of Fruit of Tribulus terrestris L.

Sperm Quality and Testicular Histomorphometry of Wistar Rats Supplemented with Extract and Fractions of Fruit of Tribulus terrestris L.

Hepatoprotective and Antioxidant Activities of Tribulus Terrestris

Ameliorative Impacts of <i>Tribulus terrestris</i> Against Ivermectin-Induced Hepato-Renal Toxicity in Rabbit: Pharmacological and Histopathological Study

Contact Info

Product

Resources

About