Chemical constituents from the stems of Machilus philippinensis Merr. and the neuroprotective activity of cinnamophilin

Abstract

The Machilus genus (Lauraceae) had been extensively utilized in folk medicine due to its broad range of bioactivities.

Cytotoxic clerodane diterpenoids from the roots of Casearia barteri Mast.

“…These were puried using chromatographic columns with various stationary phases, leading to the isolation of thirteen compounds, including six new derivatives, barterins A-F (1-6) (Fig. 1) along with seven known compounds identied as caseamembrin A (7), caseamembrin E (8), 13 the mixture of casearlucin A (9) 14 and graveospene G (10), 11 N-trans-feruloyltyramine (11), N-cis-feruloytyramine (12), 15 1). The decoupled broadband 13 C NMR spectrum of 1 exhibited resonances of 31 carbon atoms including those of 2-methylbutanoyloxy, butanoyloxy, and acetyloxy groups established from the observation of the following carbon signals (d C 175.8, 41.9, 27.7, 17.1, 12.1; 173.1, 36.7, 18.9, 13.9; 169.6, 21.9) (Table 2).…”

“…These were purified using chromatographic columns with various stationary phases, leading to the isolation of thirteen compounds, including six new derivatives, barterins A–F ( 1–6 ) (Fig. 1) along with seven known compounds identified as caseamembrin A ( 7 ), caseamembrin E ( 8 ), 13 the mixture of casearlucin A ( 9 ) 14 and graveospene G ( 10 ), 11 N-trans -feruloyltyramine ( 11 ), N-cis -feruloytyramine ( 12 ), 15 (−)-β-sitosterol-3- O -β- D -(6- O -palmitoyl)glucopyranoside ( 13 ) 16 using their spectroscopic data by comparing with those reported in the literature.…”