Chemical Constituents from the Stems of Excoecaria acertiflia

Abstract

Six new compounds, including two diterpenoids excocarinols F and G (1 and 2, resp.), two carotane (daucane) sesquiterpenoids excoecafolinols A and B (3 and 4, resp.), one lignanoid compound, excoecanol A (5), and one simple phenol, excoecanol B (6), together with 17 known compounds, were isolated from the BuOH extract of Excoecaria acerifolia Didr. stems. Their structures were elucidated through the analysis of the spectroscopic data. The AChE-inhibitory activities of 17 compounds were evaluated and revealed that four of them possessed moderate inhibitory activities against AChE.

Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems

“…Compounds 1–5 were all tested for their AchE-inhibitory activity by Ellman’s Method as described before [13]. As a result, compounds 1–3 (at the concentration of 94 nM) showed moderate activity with the AChE inhibit index (AII) 68.96 ± 0.19, 57.8 ± 0.11 and 37.55 ± 0.12 % at 94 nM, respectively, compared with the negative control (AII 8.94 ± 0.09%) and positive control (tacrine with AII 79.8 ± 0.20 %, 9.4 nM) (Table 2).…”

“…The AchE-inhibitory activity of the compounds was tested as described by Ellman’s Method in the literature [13,14]. The mixed reaction solution contained test compound soln.…”

Separation of Methanolic Leaf Extracts of Three Rutaceous Plants by Capillary Electrophoresis and High-Performance Liquid Chromatography Methods

“…It was observed that various parts of the plant namely roots, leaves, stems, barks, fruits, flowers and twigs are used for medicinal purpose, some of them are used as for food. [3] Phytochemical survey reveals that wide range of secondary metabolites alkaloids, [4] Coumarins, [5] Pyrano-coumarins, [6] limnoids, [7] essential oils, [8] insecticides [9] were isolated from the different species of Rutaceous plants. Pharmacological survey reveals that researchers around the world identified anticancer, [10] antibacterial, [7] antifungal, [7] anti-HIV, [11] immunomodulatory, [12] antinociceptive, [13] antimalarial, [14] insecticidal [9] activities of extracts and isolated compounds.…”

Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp.

“…1 This class of diterpenes can be derived from the original core by substitution, hydroxylation, acetylation, rearrangement, bromination, and ring expansion reactions. 2 Since the isolation of pimaric acid, the rst example of this class, in 1839, 3 pimarane diterpenoids have attracted considerable interest due to their remarkable structural diversity and great antimalarial, 4 antibacterial, 5 antifungal, 6 antiviral, 7,8 phytotoxic, 6 cytotoxic, [9][10][11][12] AChE-inhibitory, 13 and anti-inammatory activities. 14 Sarcosomataceous fungi (Ascomycota), usually known as degraders of wood or as pathogens, 15 have been reported to produce spirobisnaphthalenes, 16,17 lactones, 15,[18][19][20][21] naphthalones, 21 cyclohexenones, 22 and isocoumarins.…”