Chemical Constituents from the Rhizome of<i>Acorus calamus</i>L.

Dong, Weiwei; Yang, Da; Runhua, Lu

doi:10.1055/s-0029-1186217

Cited by 23 publications

(19 citation statements)

References 7 publications

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“…Based on these arguments, compound 1 was assigned as (−)-(1S/R,4S/R,7R/S,10S/R)-cadin-5-ene-1,4,7-triol, a new representative of the cadinane-type bicyclic sesquiterpenes which we have named vanderlandin. Similar di-and trihydroxylated cadinane sesquiterpenes have been isolated for example from Taiwania cryptomerioides Hayata, 22,23 the brown alga Dictyopteris divaricata, 24 and more recently, from the rhizome of Acorus calamus L. 25…”

Section: Sinularia Vanderlandimentioning

confidence: 61%

Chemical constituents of the soft corals Sinularia vanderlandi and Sinularia gravis from the coast of Madagascar

et al. 2016

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The crude extracts of the Madagascan soft corals Sinularia vanderlandi and Sinularia gravis (Alcyoniidae) showed activity against Plasmodium falciparum which led us to study their chemical constituents. The new cadinane-type sesquiterpenoid vanderlandin (1) has been obtained from S. vanderlandi along with 24-methylenecholesterol (2). Four new compounds, the spatane-type diterpenoid gravilin (3), the monoalkylmonoacylglycerol 4, the dihomoditerpenoid ketone 5, and isodecaryiol (9), along with the three known compounds (+)-(S)-geranyllinalool (6), (-)-(R)-nephthenol (7), and 11,12-epoxysarcophytol A (8) have been isolated from the methanol extract of S. gravis. The structures were elucidated based on extensive spectroscopic methods, in particular various 2D NMR techniques. The structure of isodecaryiol (9) including its absolute configuration could be confirmed by X-ray diffraction.

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Section: Sinularia Vanderlandimentioning

confidence: 61%

Chemical constituents of the soft corals Sinularia vanderlandi and Sinularia gravis from the coast of Madagascar

et al. 2016

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“…Besides its uses in traditional medicine, A. calamus has been used for digestive problems such as gas, bloating, colic, and poor digestive function; because of its rich ethnobotanical history, the herb is also used in the Ayurveda and Uniani systems of medicine. A number of bioactive constituents, viz., 2-allyl-5-ethoxy-4-methoxyphenol, 4-terpineol, lysidine, epieudesmin, spathulenol, furylethyl ketone, borneol, nonanoic acid, 2,2,5,5-tetramethyl-3-hexanol, galgravin, bornyl acetate, retusin, (9 E ,12 E ,15 E )-9,12,15-octadecatrien-1-ol, geranylacetate, butyl butanoate, sakuranin, camphor, acetic acid, isoelemicin, acetaphenone, α-ursolic acid, dehydroabietic acid, methyl ether, isoeugenol, apigenin 4,7-dimethylether, linalool, dehydrodiisoeugenol, elemicin and linolenic acid, 1 beta,7 alpha( H )-cadinane-4 alpha,6 alpha,10 alpha-triol (1), 1 alpha,5 beta-guaiane-10 alpha- O -ethyl-4 beta,6 beta-diol (2), and 6 beta,7 beta( H )-cadinane-1 alpha,4 alpha,10 alpha-triol (3) have been reported in A. calamus [ 25 , 26 , 27 ]. The phenyl propanoids, sesquiterpenes, monoterpenes, xanthone glycosides, flavones, lignans, and steroids from Acorus calamus have been reported to possess various pharmacological activities such as insecticidal, larvicidal, antibacterial, mutagenic, cytotoxic, hepatoprotective, anticonvulsant, neuroleptic, smooth muscle relaxant, and smooth muscle stimulant activity [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Seasonal Variation in Essential Oil Compositions and Antioxidant Properties of Acorus calamus L. Accessions

et al. 2017

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Background: Acorus calamus (Sweet flag) is a known herbal drug commonly used in traditional medicine. Our aim was to perform seasonal and altitudinal phytochemical screening to assess the antioxidant activity of the essential oils in the rhizome and leaves of A. calamus from three different altitudes. Methods: Phytochemical screening was performed using GC/MS analysis and in vitro antioxidant assay was done by different methods. Results: The essential oils mainly contained α-asarone, β-asarone (35.3–90.6%), and Z-isoelemicin (1.7–7.3%) as the major constituents, besides linalool, Z-methyl isoeugenol, shyobunone, kessane, etc. All the oils exhibited vast molecular diversity in terms of quantitative ingredients. All essential oils were studied for their antioxidant activity by different methods, including their effect on the DPPH radical-scavenging activity, reducing power, and chelating properties of Fe2+. The oils isolated in all the different seasons exhibited antioxidant activity as a function of concentration, with IC50 values ranging from 475.48 ± 0.08 to 11.72 ± 0.03 compared to standards. Conclusion: From the results obtained it can be inferred that the herb may be a good source of bioactive compounds and can work as an antioxidant to prevent oxidative deterioration in food. The data provide a basis for its in-situ investigation for judicious exploitation.

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“…So far, many sesquiterpenes from A. calamus mainly consist of acorane, guaiane, cadinane, and elemane-type sesquiterpenes [ 9 , 10 , 11 ]. Compounds 1 and 2 are nonisoprenoid sesquiterpenoids, and may derive from the acorane skeleton with new biogenetic pathways.…”

Section: Resultsmentioning

confidence: 99%

New Acorane-Type Sesquiterpene from Acorus calamus L.

et al. 2017

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A new sesquiterpene, named neo-acorane A (1), and two known ones, acoric acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L. Their structures were elucidated by spectroscopic methods, and the absolute configurations were determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 are nonisoprenoid sesquiterpenoids, likely biosynthesized from an acorane-type sesquiterpene by oxidative fission of the six- or five-membered ring. Moreover, compounds 1 (10 μM), 2 (5 μM and 10 μM) and 3 (10 μM) showed cell proliferation activity on the SK-N-BE (2) cell line.

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Chemical Constituents from the Rhizome ofAcorus calamusL.

Cited by 23 publications

References 7 publications

Chemical constituents of the soft corals Sinularia vanderlandi and Sinularia gravis from the coast of Madagascar

Chemical constituents of the soft corals Sinularia vanderlandi and Sinularia gravis from the coast of Madagascar

Seasonal Variation in Essential Oil Compositions and Antioxidant Properties of Acorus calamus L. Accessions

New Acorane-Type Sesquiterpene from Acorus calamus L.

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