Chemical constituents from the fruits of Psoralea corylifolia and their protective effects on ionising radiation injury

Abstract

Two new flavonoids, corylifol F (1) and corylifol G (2), together with 19 known compounds, were isolated from the fruits of Psoralea corylifolia L.. The structures of these compounds were determined by interpretation of spectroscopic data and comparison with literature properties. The radioprotective effects of the isolated compounds against ionising radiation damage were also evaluated in vitro. The results showed that corylifol A exhibited radioprotective effects in both HBL-100 and MCF-7 cells, while psoralen, isopsoralen, corylifol C and bakuchiol showed obvious selective action to protect HBL-100 cells against damage caused by ionising radiation.

Psoralea corylifolia L.: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics

“…Flavonoids are one of the key active ingredients of PCL. So far, 72 flavonoids have been isolated and identified from PCL, mainly including flavonoids (25)(26)(27), flavonols (28,29), dihydroflavonoids (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43), isoflavones and chalcones (78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91)(92)(93)(94)(95)(96). The names of the specific compounds are shown in Table 2 , and the corresponding chemical structures are displayed in Fig.…”

Fruits and their phytochemicals in mitigating the ill effects of ionizing radiation: review on the existing scientific evidence and way forward

“…At the same time, corylifol C, isopsoralen, psoralen and bakuchiol were effective only in HBL-100 cells. 194 Additionally, psoralidin, a coumestan isolated from the seed, effectively mitigates IR-induced pulmonary inflammation in cultured human normal lung fibroblasts, MRC-5 and HFL-1 in vitro. 195 Compared to the radiation alone cohorts, treatment of MRC-5 and HFL-1 cells mitigated the IR-induced fibroblast migration.…”

Pharmacologically Active Secondary Metabolites from Psoralea corylifolia

“…Improving cognitive deficits, vasoactive, osteogenic, estrogenic, PPAR-γ agonist [6], [22]- [24], [28], [30], [ Antipsoriatic, vasoactive, reducing glucose-induced mesangial cell death, hepatoprotective, antineuroinflammatory, radioprotective [24], [25], [27], [32], [34], [35] Bakuchicin Antivasorelaxant, antibacterial, antitumor, CYP1A1 and CYP1A2 inhibitor in human liver microsomes [36], [37] Seed, fruit Furanocoumarin Psoralen Antipsoriatic, Anti-inflammatory, vasoactive, antineuroinflammatory, neuroprotective, hepatoprotective, DGAT and α-glucosidase inhibitor, radioprotective [21], [24], [25], [27], [30], [32], [34] Seed, fruit Coumestrols Psoralidin Antipsoriatic, preventing age-related cognitive deficits, vasoactive, anti-neuroinflammatory, neuroprotective, anticancer [22], [24], [25], [34]…”