Chemical Constituents from the Colombian Medicinal Plant Maytenus laevis

Nakagawa, Hiroyuki; Takaishi, Yoshihisa; Fujimoto, Yoshinori; Duque, Carmenza; Garzón, Cristina; Sato, Mitsunobu; Okamoto, Masato; Oshikawa, Tetsuya; Ahmed, Sharif Uddin

doi:10.1021/np040006s

Cited by 34 publications

(26 citation statements)

References 46 publications

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“…Thus, from the above data and comparing to the literature for similar structures (Garson et al, 2006;Nakagawa et al, 2004;Ohsaki et al, 2004) compound 1 was confirmed to be α-amyrin derivative esterified with 5-hydroxy ferulic acid at position C-3. The position of the methoxyl group at C-3' was deduced from the different chemical shifts of the aromatic proton H-2' and H-6' and confirmed by the HMBC correlations which showed, amongst other correlations, a cross peak between MeO/C-3' and H-2'/C-3', C-4'.…”

Section: Compoundsupporting

confidence: 70%

Hypoglycemic evaluation of a new triterpene and other compounds isolated from Euclea undulata Thunb. var. myrtina (Ebenaceae) root bark

Deutschländer

Lall

Venter

et al. 2011

Journal of Ethnopharmacology

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Aim of the study: Investigate the hypoglycaemic activity of the four isolated compounds from a crude acetone extract of the root bark of Euclea undulata var. myrtina, which is used by traditional healers in the Venda area, Limpopo Province in the treatment of diabetes. Material and Methods:The hypoglycaemic activity of the four compounds isolated from E. undulata was determined by in vitro screening of glucose utilization by C2C12 myocytes at a concentration of 25 µg/ml or 50 µg/ml. The inhibition of α-glucosidase was also tested at concentrations ranging from 0.02 to 200.00 µg/ml.Results: Assay-guided isolation of the crude acetone extract of the root bark of E. undulata var. myrtina. afforded a new triterpene, α-amyrin-3O-ß-(5-hydroxy) ferulic a c i d ( 1 ) , in addition to three known compounds; betulin (2), lupeol (3) and epicatechin (4). The in vitro results on C2C12 myocytes suggest that compound 4 may have some effect to lowers blood glucose levels, whereas compound 1 has the ability to inhibit α-glucosidase at a concentration of 200.0 µg/ml with an IC 50 value of 4.79 that correlates with that of the positive control acarbose IC 50 value 4.75. Conclusion:The results suggest that 4 may have some ability to lower blood glucose levels, whereas 1 has the ability to inhibit α-glucosidase.Ethnopharmacological relevance: These findings corroborate the ethnomedicinal use of E. undulata by traditional healers for the treatment of diabetes as two substances was isolated from the acetone plant extract that exhibit hypoglycaemic activity.

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Section: Compoundsupporting

confidence: 70%

Hypoglycemic evaluation of a new triterpene and other compounds isolated from Euclea undulata Thunb. var. myrtina (Ebenaceae) root bark

Deutschländer

Lall

Venter

et al. 2011

Journal of Ethnopharmacology

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“…Compounds showing greater than 70% inhibition of particular cytokines included 27 and wilforine (16) for TNF-α, and euonine (=wilformine) (21) for IFN-γ. On the other hand, 27 and mayteine (26) induced IL-6 and, weakly, TNF-α in human peripheral blood mononuclear cells (Nakagawa et al, 2004); this could have antitumor but also proinflammatory effects. The alkaloids wilfordsine (24), wilfordconine (28), and wilfornine (20) were reported to be immunosuppressive (Deng et al, 1987a;Lin et al, 1995Lin et al, , 2001b, and wilfortrine (15), euonine (21), and wilforine (16) inhibited the humoral immune response (antibody-mediated responses) in animals (Zheng et al, 1989;Xia and Chen, 1990).…”

Section: Insecticidal Activitymentioning

confidence: 97%

“…Salaspermic acid (76) weakly stimulated proapoptotic cytokines, suggesting the possibility of antitumor activity (Nakagawa et al, 2004). Regeol B (73) inhibited TPA-induced EBV-EA .…”

Section: Cancermentioning

confidence: 99%

“…Regelide (93) also had weak IL-12 and TNF-α induction activity. These activities may have antitumor effects (Nakagawa et al, 2004).…”

Section: Cancermentioning

confidence: 99%

“…It also inhibited DNA topoisomerase II (Mizushina et al, 2003) and weakly inhibited the lyase activity of DNA polymerase β (Chaturvedula et al, 2004). Triptocallic acid A's (100) ability to induce IL-6 suggests it may have antitumor effects (Nakagawa et al, 2004).…”

Section: Insecticidal Activitymentioning

confidence: 99%

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Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

et al. 2007

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Plants in the genus Tripterygium, such as Tripterygium wilfordii Hook. f., have a long history of use in traditional Chinese medicine. In recent years there has been considerable interest in the use of Tripterygium extracts and of the main bioactive constituent, the diterpene triepoxide triptolide (1), to treat a variety of autoimmune and inflammation-related conditions. The main mode of action of the Tripterygium extracts and triptolide (1) is the inhibition of expression of proinflammatory genes such as those for interleukin-2 (IL-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2) and interferon-gamma (IFN-γ). The efficacy and safety of certain types of Tripterygium extracts were confirmed in human clinical trials in the US and abroad. Over 300 compounds have been identified in the genus Tripterygium, and many of these have been evaluated for biological activity. The overall activity of the extract is based on the interaction between its components. Therefore, the safety and efficacy of the extract cannot be fully mimicked by any individual constituent. This review discusses the biochemical composition and biological and pharmacological activities of Tripterygium extracts, and their main bioactive components.

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Lupane‐ and Friedelane‐Type Triterpenoids from Celastrus stylosus

Ying

Chen

et al. 2015

Chemistry & Biodiversity

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Two new triterpenoids, 30-hydroxylup-20(29)-ene 3β-caffeate (1) and 24-nor-friedelan-6α,10-dihydroxy-1,2-dioxo-4,7-dien-29-oic acid (2), together with eight known compounds 3-10, were isolated from the roots of Celastrus stylosus. The structures of these compounds were elucidated on the basis of spectroscopic analyses. To the best of our knowledge, this represents the first study on the chemical constituents of C. stylosus. The antiproliferative activities of the triterpenoids against six human cancer cell lines (PANC-1, A549, PC-3, HepG2, SGC-7901, and HCCLM3) were evaluated. Compounds 3, 4, and 10 exhibited comparable activities against PC-3 and HCCLM3 cell lines as the positive control taxol.

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Chemical Constituents from the Colombian Medicinal Plant Maytenus laevis

Cited by 34 publications

References 46 publications

Hypoglycemic evaluation of a new triterpene and other compounds isolated from Euclea undulata Thunb. var. myrtina (Ebenaceae) root bark

Hypoglycemic evaluation of a new triterpene and other compounds isolated from Euclea undulata Thunb. var. myrtina (Ebenaceae) root bark

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

Lupane‐ and Friedelane‐Type Triterpenoids from Celastrus stylosus

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