Chemical constituents from the branches of Millettia brandisiana and their biological activities

Arthan, Supakorn; Yenjai, Chavi; Pornchoo, Chanakan; Prawan, Auemduan

doi:10.1016/j.phytol.2022.12.019

Cited by 1 publication

(2 citation statements)

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“…Additionally, nine flavonoid derivatives from M. brandisiana Kurz including compounds 9 , 10 , 11 , 16 , 17 , 18 , genistein ( 20 ), isoprunetin ( 21 ), and formononetin ( 22 ) were isolated based on our previously published research. , The positive control baicalein was purchased from Sigma-Aldrich.…”

Section: Methodsmentioning

confidence: 99%

“…33 Additionally, nine flavonoid derivatives from M. brandisiana Kurz including compounds 9, 10, 11, 16, 17, 18, genistein (20), isoprunetin (21), and formononetin (22) were isolated based on our previously published research. 34,35 The positive control baicalein was purchased from Sigma-Aldrich. Six flavonoids, namely, pinocembrin (1), pinostrobin (2), alpinetin (3), cardamonin (14), pinostrobin chalcone (15), and panduratin A (19), were isolated from the rhizome of B. rotunda (L.) Mansf.…”

Section: Isolation and Collection Of Flavonoidsmentioning

confidence: 99%

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Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CL^pro: Insights from the Computational and Experimental Investigations

Khamto,

Utama,

Boontawee

et al. 2024

J. Chem. Inf. Model.

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The emergence of the COVID-19 situation has become a global issue due to the lack of effective antiviral drugs for treatment. Flavonoids are a class of plant secondary metabolites that have antiviral activity against SARS-CoV-2 through inhibition of the main protease (3CL pro ). In this study, 22 flavonoids obtained from natural sources and semisynthetic approaches were investigated for their inhibitory activity against SARS-CoV-2 3CL pro , along with cytotoxicity on Vero cells. The protein−ligand interactions were examined using molecular dynamics simulation. Moreover, QSAR analysis was conducted to clarify the structural effects on bioactivity. Accordingly, the in vitro investigation demonstrated that four flavonoids, namely, tectochrysin (7), 6″,6″dimethylchromeno-[2″,3″:7,8]-flavone (9), panduratin A ( 19), and genistein (20), showed higher protease inhibitory activity compared to the standard flavonoid baicalein. Finally, our finding suggests that genistein (20), an isoflavone discovered in Millettia brandisiana, has potential for further development as a SARS-CoV-2 3CL pro inhibitor.

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Section: Methodsmentioning

confidence: 99%

Section: Isolation and Collection Of Flavonoidsmentioning

confidence: 99%

Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CL^pro: Insights from the Computational and Experimental Investigations

Khamto,

Utama,

Boontawee

et al. 2024

J. Chem. Inf. Model.

Self Cite

View full text Add to dashboard Cite

show abstract

Chemical constituents from the branches of Millettia brandisiana and their biological activities

Cited by 1 publication

References 23 publications

Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CL^pro: Insights from the Computational and Experimental Investigations

Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CL^pro: Insights from the Computational and Experimental Investigations

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Chemical constituents from the branches of Millettia brandisiana and their biological activities

Cited by 1 publication

References 23 publications

Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLpro: Insights from the Computational and Experimental Investigations

Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLpro: Insights from the Computational and Experimental Investigations

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Product

Resources

About

Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CL^pro: Insights from the Computational and Experimental Investigations

Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CL^pro: Insights from the Computational and Experimental Investigations