Chemical constituents from the Antarctic lichen Usnea aurantiaco-atra and their chemotaxonomic significance

Phi, Kim-Hoa; So, Jae Eun; Kim, Jihee; Koo, Man Hyung; Kim, Jin-Hyoung; Kim, Dockyu; Lee, Jun Hyuck; Lee, Seulah; Youn, Ui Joung

doi:10.1016/j.bse.2022.104581

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…Our study complements other recent phytochemical analysis from the lichen U. aurantiaco-atra in which usnic acid, terpenes and ergosta compounds were present [16]. We aim to confirm the presence of these metabolites and to add new ones.…”

Section: Introductionsupporting

confidence: 75%

Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities

Vega-Bello,

Moreno,

Estellés-Leal

et al. 2023

Molecules

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Background: Lichens are complex symbiotic associations between a fungus and an alga or cyanobacterium. Due to their great adaptability to the environment, they have managed to colonize many terrestrial habitats, presenting a worldwide distribution from the poles to the tropical regions and from the plains to the highest mountains. In the flora of the Antarctic region, lichens stand out due to their variety and development and are a potential source of new bioactive compounds. Methods: A phytochemical study of the Antarctic lichen Usnea aurantiaco-atra (Jacq) Bory was conducted with the intention of determining the most important metabolites. In addition, the cytotoxic and antioxidant activities of its extracts were determined. Results: Cytotoxicity studies revealed that the hexane extract contains usnic acid as a majority metabolite, in addition to linoleic acid, ergosterols and terpenes, and demonstrates cytotoxic activity against an A375 melanoma cell line. On the other hand, the presence of total phenols in the extracts did not influence their antioxidant activity. Conclusions: U. aurantiaco-atra contains mainly usnic acid, although there are terpenes and ergosta compounds that could be responsible for its cytotoxic activity. The presence of phenols did not confer antioxidant properties.

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Section: Introductionsupporting

confidence: 75%

Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities

Vega-Bello,

Moreno,

Estellés-Leal

et al. 2023

Molecules

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“…Phenolic compounds of lichen extracts used for biological activities are all derivatives of the orcinol type [1,2]. They are aromatic compounds containing phenolic carboxylic acids.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activity of Mycobiont Extract of Parmotrema austrosinense (Zahlbr.) Hale in a Zebrafish Model

Rajendran

Karuppiah

Ponmurugan

et al. 2023

JMSE

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Thousands of different kinds of lichen metabolites are being examined for their biological activities, including anticancer properties. In this context, the present study aims to assess the anti-inflammatory activity of the acetone extract of Parmotrema austrosinense mycobiont. A lipid peroxidation assay was performed with the acetone extracts of P. austrosinense mycobiont, which was further used to evaluate its anti-inflammatory efficacy using a zebrafish model. Furthermore, the histopathological study was also carried out with muscle tissues and amplification of its inflammation marker. The results revealed that the lichen compound (i.e., lecanoric acid) in the acetone extract of P. austrosinense possesses anti-inflammatory activity. Histopathology studies confirmed the decreased numbers of neutrophil cells in the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced zebrafishes, as confirmed by changes in the fishes’ weight before and after the sample treatment, prompted by TNBS inflammation. The present results also demonstrated a dose-dependent decrease in the lipid peroxidation (LPO) levels in the muscle tissues of zebrafishes. Gene amplification studies suggested that the lichen compound might perform dose-dependent downregulation of the inflammatory gene marker of the tumor necrosis factor (TNF)-α gene; this further confirms that the extract should possess anti-inflammatory activity. As per the literature, this study is one of the most complete, comprehensive in vivo anti-inflammatory analyses in which inflammation was induced in zebrafish by using 2,4,6-trinitrobenzene sulfonic acid (TNBS). Particularly, this study successfully identified a bioactive compound isolated from the lichen P. austrosinense, and which exhibited decent anti-inflammatory activity.

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