Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities

Dong, Hao; Geng, Yun; Wang, Xueyong; Song, Xiangyun; Wang, Xiao; Yu, Jinqian

doi:10.3390/molecules23102577

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…They exert in the protection of human health, preventing various (inflammation, colorectal cancer, liver cancer, and DNA damage) diseases (36)(37)(38)(39). Other plants belonging to the Araceae family contain phytochemicals such as sterols, saponins, phenols, and alkaloids (34,40,41). N. fruticans contains phytochemicals, such as chlorogenic acid, kaempferol, and protocatechuic acid (4,21,42), which have antioxidant, anticancer, and anti-inf lammatory effects (43)(44)(45).…”

Section: Discussionmentioning

confidence: 99%

Anti‑inflammatory effects of Nypa fruticans Wurmb via NF‑κB and MAPK signaling pathways in macrophages

et al. 2022

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The inflammatory defense response of macrophages is a natural protective reaction in the immune system. Antioxidant and anti-inflammatory activities are closely related. In addition, the cell signaling pathway regulating inflammation is associated with MAPK and NF-κB signaling pathway phosphorylation. The present study aimed to evaluate whether the ethyl acetate fraction from N. fruticans (ENF) has a modulatory role in the MAPK signaling pathway and inhibition of the IκB/NF-κB signaling pathways, including translocation of NF-κB p65. Antioxidant and anti-inflammatory activities are closely related. In addition, the cell signaling pathway regulating inflammation is associated with MAPK and NF-κB signaling pathway phosphorylation. The results revealed that ENF exhibited antioxidant capacity, attenuated the cytokine levels and blocked nitric oxide production. ENF downregulated cyclooxygenase-2 and inducible nitric oxide synthase expression. We hypothesized that ENF treatment alleviated the various proinflammatory mediators via IκB phosphorylation and transcription of NF-κB compared with the untreated control. In conclusion, the present study demonstrated that the inhibitory effect of ENF treatment was attributed to the inhibition of MAPK and Akt/IκB/NF-κB signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Anti‑inflammatory effects of Nypa fruticans Wurmb via NF‑κB and MAPK signaling pathways in macrophages

et al. 2022

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“…The anti-inflammatory activity assay of NO production in RAW264.7 cells was determined using the reported method. , RAW264.7 cells in the logarithmic growth phase were cultivated in 96-well plates (Costar, USA) at 2 × 10 5 cells per well in an RPMI-1640 medium with 10% FBS, 100 μg/mL of streptomycin, and 100 U/mL of penicillin. The 96-well plates were placed in an incubator maintained at 37 °C with 5% CO 2.…”

Section: Methodsmentioning

confidence: 99%

Extraction of Flavonoids from Scutellariae Radix using Ultrasound-Assisted Deep Eutectic Solvents and Evaluation of Their Anti-Inflammatory Activities

et al. 2020

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Deep eutectic solvents (DESs) play important roles in the extraction of active constituents in traditional Chinese medicine. Ultrasound-assisted DES has been used to extract flavonoids from Scutellaria baicalensis . Using the contents of scutellarin, baicalin, baicalein, wogonoside, wogonin, and oroxylin A as quantitative indices, different kinds of DESs have been optimized for extraction and betaine/acetic acid has shown the highest yield. The Box–Behnken response surface method (RSM) was utilized to select the extraction conditions with the highest yields. The optimal extraction conditions were as follows: the molar ratio of betaine/acetic acid was 1:4, the water content was 40%, the solid/liquid ratio was 1:100 g/mL, the extraction temperature was 52 °C, and the extraction time was 23 min. Compared with traditional reflux extraction using 70% ethanol as the solvent, ultrasound-assisted DES has a shorter extraction time and higher yields. Furthermore, anti-inflammatory activities of the two extracts by ultrasound-assisted DES and reflux were compared using RAW264.7 cells and the methyl thiazolyl tetrazolium (MTT) method, and they showed equal anti-inflammatory activities. The results demonstrated that the ultrasound-assisted DES method for extraction of flavonoids from scutellariae radix is simple, green, efficient, and reproducible. This research provides good method guides for the rapid and efficient extraction of flavonoids from natural sources.

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“…Meanwhile, the health risks and eco-unfriendly effects also appeared. − The increment of environmental preoccupations and the growing demands for more high-yielding and healthy food call for green alternatives to resistant insecticides. Hopefully, plant secondary metabolites, defended against chewing herbivores in the process of the ongoing evolution of plant–pest interactions, are the important sources for the discovery of novel pesticide candidates. ,, Caffeoyl and flavonoid derivatives, as widespread secondary metabolites in various plants, exhibited many bioactivities, including anti-inflammation, antiviral, antioxidant, antibacterial, and anticancer, while their bioactivities in agriculture were reported scarcely. − …”

Section: Introductionmentioning

confidence: 99%

High Value-Added Application of Natural Products in Crop Protection: Discovery and Exploration of Caffeoyl and Flavonoid Derivatives from Clematis brevicaudata DC. as Novel Insecticide Candidates

Hao,

Liang,

Sun

et al. 2024

J. Agric. Food Chem.

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Nine caffeoyl derivatives (1−9), including two new dicaffeoyl glycosides, brevicaudatosides A and B (1 and 2), and six flavonoids (10−15), were identified from overground Clematis brevicaudata DC. Compounds 1 and 13 exhibited significant oral toxicities against Acyrthosiphon pisum Harris with LC 50 (half-lethal concentration) values of 0.12 and 0.28 mM, respectively. Meanwhile, compounds 1, 8, 10, 13, and 15 showed remarkable repellent effects against A. pisum with the repellent indexes valued at 1.00 under 50−200 μg/mL at 24 h. Compounds 1 and 8 also displayed moderate antifeedant activities against Plutella xylostella L. The shrunken bodies, especially for wizened cauda, and the ultrastructural damages of microvilli, mitochondrion, nucleus, and endoplasmic reticulum in midgut were toxic symptoms of A. pisum caused by 1 and 13. The inhibition of Chitinase was the main reason for their potent insecticidal activities. This study provided valuable pieces of evidence for the high value-added application of caffeoyl and flavonoid derivatives from C. brevicaudata as novel plant-origin biopesticides for crop protection.

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Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities

Cited by 6 publications

References 14 publications

Anti‑inflammatory effects of Nypa fruticans Wurmb via NF‑κB and MAPK signaling pathways in macrophages

Anti‑inflammatory effects of Nypa fruticans Wurmb via NF‑κB and MAPK signaling pathways in macrophages

Extraction of Flavonoids from Scutellariae Radix using Ultrasound-Assisted Deep Eutectic Solvents and Evaluation of Their Anti-Inflammatory Activities

High Value-Added Application of Natural Products in Crop Protection: Discovery and Exploration of Caffeoyl and Flavonoid Derivatives from Clematis brevicaudata DC. as Novel Insecticide Candidates

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