Chemical constituents from Munronia sinica and their bioactivities

Abstract

Abstract:Two new minor constituents, musinisins A (1) and B (2), together with five known compounds (3-7), were isolated from the aerial parts of Munronia sinica. Their structures were established by means of spectroscopic methods and the absolute stereochemistry of 1 was determined by single crystal X-ray experiment. Compound 4 showed antiangiogenic activity evaluated by a zebrafish model and apoptosis-inducing effect on A549 lung cancer cells.

Diverse Ring‐seco Limonoids from Munronia unifoliolata and Their Biological Activities

“…[ 11 ] At present, there are only a few reports on the research of M. unifoliolata , but a large number of limonoids with significant anti‐inflammatory, antimicrobial, and anti‐TMV biological activities have been isolated from its genus. [ 12‐19 ] In order to understand the main and active ingredients of M. unifoliolata , the systematic extraction and separation of dichloromethane extract, the main anti‐inflammatory active portion of the whole plants (IC 50 = 17.9 ± 4.6 μmol/L), were carried out in our current research. This resulted in isolation of twenty‐two new limonoids ( 1 — 22 ), including rings A, B‐ seco , ring A‐ seco , and ring‐intact types.…”

Phytochemistry and Pharmacology of <i>Munronia</i> Genus (Meliaceae)

“…It was reported that tigloyl unit appears to be attached on C-12 of 30-34. From M. sinica, Li et al [67] obtained limonoid compound, 6,7-bis(acetyloxy)-4,4,8-trimethyl-3-oxo-(5α,6α,7α,13α,17α,20ξ)-carda-1,14-dienolide (38). Species of M. unifoliata also produced many new limonoids with interesting diversity.…”

“…M. henryi produced glycosides, α-D-glucopyranosyl-6'-O-hexadecanoate (83), 4-O-α-D-psicofuranos-α-D-glucopyranose (84), and glyceryl-1-tetracosanoicate (85) [57]. Meanwhile, M. sinica contained other glycosides such as musinins A and B (86 and 87), glucoacetosyringone (88), cannabiside D (89), corchoionoside C (90), and (+)-3-oxo-α-ionyl glucoside (91) [67]. Flavonoid compounds were obtained from M. delavayi, such as kaempferol (92), quercetin (93), and rutin (94) [59].…”

“…Plants of the genus Munronia have long been used in traditional medicine in various countries such as China, India, and Sri Lanka for treatment of dysentery, fever, malaria, skin disease, and purification of blood due to venomous snake bite [55] and to prevent hiccups, vomiting and sore throats [56]. Four species have been reported from this genus, and compounds have shown interesting biological activities such as insect antifeedant [51,57], antimicrobial [66], anti-tobacco mosaic virus [61,[68][69], antiangiogenic [67], and cytotoxic activity [61].…”

Comparison of Hypoglycaemic, Hepatoprotective and Antiinflammatory Activities of Natural Plant and Callus Cultures of Munroina pinnata

“…Two new compounds, musinisins A (1) and B (2), together with five known compounds, including glucoacetosyringone (3),10 6,7-bis (acetyloxy)-4,4,8trimethyl-3-oxo-(5a,6a,7a,13a,17a,20)-carda-1,l4 dienolide (4), 11 cannabiside D (5),12 corchoionoside C (6) and 13 (+)-3-oxo-cL-ionyl glucoside (7) have been identified. Further, these compounds were tested for their antiangiogenic activities using a zebrafish model and the antiproliferative activities using A549 lung cancer cells (Li et al, 2012). To date, there has been only a few scientific investigations were recorded in Sri Lanka on chemical constituents from methylene chloride fraction of ethanolic extracts of M pinnata such as one fatty acid containing 15 Carbon atoms (Rf = 0.52) and one triterpenoid containg 34 Carbon atoms (Rf = 0.36) however their structures were not elucidated (Munasinghe, 2002).…”