Chemical constituents from <i>Gueldenstaedtia verna</i> and their anti-inflammatory activity

Liu, Xin; Yin, Chang-Cheng; Cao, Yue; Zhou, Jianhua; Wu, Tao; Cheng, Zhihong

doi:10.1080/14786419.2017.1320795

Cited by 10 publications

(3 citation statements)

References 17 publications

(2 reference statements)

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“…Compounds 7 – 20 were identified as 3,4-dihydroxybenzaldehyde ( 7 ), 4-hydroxybenzaldehyde ( 8 ), isovanillin ( 9 ), 3-hydroxy-4-methoxybenzoic acid ( 10 ), 3′,4′-dihydroxyacetophenone ( 11 ), syringic acid ( 12 ), salvianolic acid A ( 13 ), methyl salvionolate A ( 14 ), caffeic acid ( 15 ), 4-hydroxycinnamic acid ( 16 ), isoferulic acid ( 17 ), methyl ( R )-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate ( 18 ), rosmarinic acid ( 19 ), and methyl rosmarinate ( 20 ), respectively, based on the comparisons of their physical data with reported values.…”

Section: Resultsmentioning

confidence: 99%

Salviachinensines A–F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal PlantSalvia chinensis

Wang

et al. 2018

J. Nat. Prod.

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Six new phenolic acid derivatives, salviachinensines A−F (1−6), together with 14 known compounds (7−20) were isolated from the Chinese medicinal plant Salvia chinensis. The structures of salviachinensines A−F (1−6) were elucidated by NMR spectroscopy, bioinspired chemical synthesis, ECD analysis, and quantum chemical calculation methods. Compounds 2 and 3 are a pair of cis−trans isomers, and compounds 5 and 6 a pair of epimers. The solventinduced isomerization of compounds 5 and 6 and the hypothetical biogenetic pathway of compounds 1−6, as well as the antiproliferative property and the ability of 1 to induce apoptosis and arrest cell cycle progression of MOLM-13 cells, were also investigated.

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Section: Resultsmentioning

confidence: 99%

Salviachinensines A–F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal PlantSalvia chinensis

Wang

et al. 2018

J. Nat. Prod.

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“…In addition to the identification of genistein, the fractionation and HPLC isolation of UCME identified eight compounds, including an isoflavone (lupinalbin A [18]), three phenolic acids ( p -hydroxybenzoic acid [19], salicylic acid [20], and vanillic acid [19]), two fatty acids (monomethyl succinate [21] and 1,10-decanedioic acid [22]), and two steroids (a mixture of β -sitosterol and stigmasterol [23]). Their structures (Figure 5) were identified by comparing their spectroscopic data with data in the literature.…”

Section: Resultsmentioning

confidence: 99%

Bioactivity-Guided Fractionation and NMR-Based Identification of the Immunomodulatory Isoflavone from the Roots of Uraria crinita (L.) Desv. ex DC

Chan

Liu

et al. 2019

Foods

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Uraria crinita is used as a functional food ingredient. Little is known about the association between its immunomodulatory activity and its metabolites. We applied a precise strategy for screening metabolites using immunomodulatory fractions from a U. crinata root methanolic extract (UCME) in combination with bioactivity-guided fractionation and NMR-based identification. The fractions from UCME were evaluated in terms of their inhibitory activity against the production of pro-inflammatory cytokines (IL-6 and TNF-α) by lipopolysaccharide (LPS)-stimulated mouse bone marrow-derived dendritic cells (BMDC). The role of the isoflavone genistein was indicated by the 1H NMR profiling of immunomodulatory subfractions (D-4 and D-5) and supported by the result that genistein-knockout subfractions (D-4 w/o and D-5 w/o) had a lower inhibitory activity compared to genistein-containing subfractions. This study suggests that genistein contributes to the immunomodulatory activity of UCME and will help in the standardization of functional food.

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“…Previous research has shown that hyperoside exerts an obvious protective effect on liver tissue and that its mechanism is related to its antioxidant activity, by which it promotes the return of NO to normal levels and improves SOD activity [ 51 ]. New research on sulfuretin has shown that this polyphenol can inhibit inflammation [ 52 ]. These four substances are responsible for the protective effects of Shoumei polyphenols against CCl 4 -induced liver injury.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Capacity-Related Preventive Effects of Shoumei (Slightly Fermented Camellia sinensis) Polyphenols against Hepatic Injury

Wei

Tan

et al. 2020

Oxidative Medicine and Cellular Longevity

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Shoumei is a kind of white tea (slightly fermented Camellia sinensis) that is rich in polyphenols. In this study, polyphenols were extracted from Shoumei. High-performance liquid chromatography (HPLC) showed that the polyphenols included mainly gallic acid, catechin, hyperoside, and sulfuretin. In an in vitro experiment, H2O2 was used to induce oxidative damage in human normal hepatic L-02 cells. In an animal experiment, CCl4 was used to induce liver injury. The in vitro results showed that Shoumei polyphenols inhibited oxidative damage in normal hepatic L-02 cells, and the in vivo results showed that the polyphenols effectively reduced liver index values in mice with liver injury. The polyphenols also decreased aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), triglyceride (TG), total cholesterol (TC), blood urea nitrogen (BUN), nitric oxide (NO), malondialdehyde (MDA), interleukin 6 (IL-6), interleukin 12 (IL-12), tumour necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) levels and increased albumin (ALB), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) levels in the serum of mice with liver injury. Furthermore, pathological observation showed that the Shoumei polyphenols reduced CCl4-induced hepatocyte damage. qRT-PCR and Western blotting showed that the polyphenols upregulated the mRNA and protein expression of neuronal nitric oxide synthase (nNOS), endothelial nitric oxide synthase (eNOS), manganese- (Mn-) SOD, copper/zinc- (Cu/Zn-) SOD, CAT, and inhibitor of nuclear factor kappa B (NF-κB) alpha (IκB-α) and downregulated the expression of inducible nitric oxide synthase (iNOS) and NF-κB p65. The Shoumei polyphenols had a preventive effect against CCl4-induced mouse liver injury equivalent to that of silymarin. The four polyphenols identified as the key substances responsible for this effect mediated the effect through their antioxidant capacity. These results suggest that Shoumei polyphenols are high-quality natural products with liver-protective effects.

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Chemical constituents from Gueldenstaedtia verna and their anti-inflammatory activity

Cited by 10 publications

References 17 publications

Salviachinensines A–F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal PlantSalvia chinensis

Salviachinensines A–F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal PlantSalvia chinensis

Bioactivity-Guided Fractionation and NMR-Based Identification of the Immunomodulatory Isoflavone from the Roots of Uraria crinita (L.) Desv. ex DC

Antioxidant Capacity-Related Preventive Effects of Shoumei (Slightly Fermented Camellia sinensis) Polyphenols against Hepatic Injury

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