Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells

Zhang, Cheng‐Chen; Yin, Xia; Cao, Chenyu; Wei, Jing; Zhang, Qiang; Gao, Jin‐Ming

doi:10.1016/j.bmcl.2015.10.016

Cited by 62 publications

(38 citation statements)

References 30 publications

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“…In addition, the oligosaccharide fraction isolated from the mycelium of the Lingzhi and/or Reishi medicinal mushroom Ganoderma lucidum exhibits anticonvulsant and neuroprotective effects (Tello et al, 2013). The chemical constituents from H. erinaceus can stimulate NGF-mediated neurite outgrowth (Phan et al, 2013; Zhang et al, 2015), while Erinacine A can act as an anti-neuroinflammatory agent that confers neuroprotection in Parkinson’s disease rat model (Kuo et al, 2016). The same compound can ameliorate AD-related pathologies in APPswe/PS1dE9 transgenic mice (Tsai-Teng et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Docking Studies and Biological Evaluation of a Potential β-Secretase Inhibitor of 3-Hydroxyhericenone F from Hericium erinaceus

Chen

Yong²,

Yang³

et al. 2017

Front. Pharmacol.

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Alzheimer’s disease (AD) is the most common neurodegenerative disorder, affecting approximately more than 5% of the population worldwide over the age 65, annually. The incidence of AD is expected to be higher in the next 10 years. AD patients experience poor prognosis and as a consequence new drugs and therapeutic strategies are required in order to improve the clinical responses and outcomes of AD. The purpose of the present study was to screen a certain number of potential compounds from herbal sources and investigate their corresponding mode of action. In the present study, the learning and memory effects of ethanol:water (8:2) extracts from Hericium erinaceus were evaluated on a dementia rat model. The model was established by intraperitoneal injection of 100 mg/kg/d D-galactose in rats. The results indicated that the extracts can significantly ameliorate the learning and memory abilities. Specific active ingredients were screened in vivo assays and the results were combined with molecular docking studies. Potential receptor–ligand interactions on the BACE1-inhibitor namely, 3-Hydroxyhericenone F (3HF) were investigated. The isolation of a limited amount of 3HF from the fruit body of H. erinaceus by chemical separation was conducted, and the mode of action of this compound was verified in NaN3-induced PC12 cells. The cell-based assays demonstrated that 3HF can significantly down-regulate the expression of BACE1 (p < 0.01), while additional AD intracellular markers namely, p-Tau and Aβ1-42 were further down-regulated (p < 0.05). The data further indicate that 3HF can ameliorate certain mitochondrial dysfunction conditions by the reversal of the decreasing level of mitochondrial respiratory chain complexes, the calcium ion levels ([Ca2+]), the inhibiton in the production of ROS, the increase in the mitochondrial membrane potential and ATP levels, and the regulation of the expression levels of the genes encoding for the p21, COX I, COX II, PARP1, and NF-κB proteins. The observations suggest the use of H. erinaceus in traditional medicine for the treatment of various neurological diseases and render 3HF as a promising naturally occurring chemical constituent for the treatment of AD via the inhibition of the β-secretase enzyme.

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Section: Discussionmentioning

confidence: 99%

Docking Studies and Biological Evaluation of a Potential β-Secretase Inhibitor of 3-Hydroxyhericenone F from Hericium erinaceus

Chen

Yong²,

Yang³

et al. 2017

Front. Pharmacol.

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“…In our recent effort to search for neurotrophic natural products [13][14][15][16], we employed rat dopaminergic PC12 cells as an in vitro cell model to screen various natural compounds for the effect on nerve growth factor (NGF)-induced neurite outgrowth. The active compounds are expected to be potentially useful for the treatment of Alzheimer's disease and other neurological disorders [17,18]. Here, two new picrotoxane-type sesquiterpene glycosides, nepalactones A (1) and B (2), and one new polyprenyled coumarin, nepalarin (3) (Figure 1), were isolated from the root barks of this plant.…”

Section: Introductionmentioning

confidence: 95%

“…Compounds (1-3, and 1a-1e) were evaluated for the effect on NGF-induced neurite outgrowth in rat pheochromocytoma PC12 cells according to our previously reported procedures [17,18].…”

Section: Neuriteoutgrowth-promoting Activitymentioning

confidence: 99%

Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity

et al. 2016

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Abstract:Two picrotoxane sesquiterpene lactone glycosides, nepalactones A (1) and B (2), and one new coumarin, nepalarin (3), were isolated from the root barks of the poisonous plant Coriaria nepalensis. Their structures were elucidated via HRESIMS and 1D and 2D NMR spectroscopic analyses, and further verified via transformation methods. In addition, compounds 1-3 and five semisynthetic congeners (1a-e) were assayed for the activity to induce neurite outgrowth in rat pheochromocytoma (PC12) cells. As a result, nepalactone A derivative 1c and nepalarin (3) significantly enhanced nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells.

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“…Hericium erinaceus has a long history as a medicine [17] and has been found to promote positive nerve and brain health. It has great potential in treating neurological disorders as it contains neurotrophic compounds that can pass through the blood-brain barrier [18,19]. Bioactive compounds extracted from its fruiting body or mycelium ( Figure 1) have been demonstrated to possess antioxidative [20], antidiabetic [21], anticancer [22,23], anti-inflammatory [24], antimicrobial [23], antihyperglycemic [25], and hypolipidemic properties [26].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Hericium erinaceus for Depressive Disorder

Chong

Fung

Wong

et al. 2019

IJMS

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Depression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects. Hericium erinaceus, also known as Lion’s mane mushroom, has been shown to have various health benefits, including antioxidative, antidiabetic, anticancer, anti-inflammatory, antimicrobial, antihyperglycemic, and hypolipidemic effects. It has been used to treat cognitive impairment, Parkinson’s disease, and Alzheimer’s disease. Bioactive compounds extracted from the mycelia and fruiting bodies of H. erinaceus have been found to promote the expression of neurotrophic factors that are associated with cell proliferation such as nerve growth factors. Although antidepressant effects of H. erinaceus have not been validated and compared to the conventional antidepressants, based on the neurotrophic and neurogenic pathophysiology of depression, H. erinaceus may be a potential alternative medicine for the treatment of depression. This article critically reviews the current literature on the potential benefits of H. erinaceus as a treatment for depressive disorder as well as its mechanisms underlying the antidepressant-like activities.

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Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells

Cited by 62 publications

References 30 publications

Docking Studies and Biological Evaluation of a Potential β-Secretase Inhibitor of 3-Hydroxyhericenone F from Hericium erinaceus

Docking Studies and Biological Evaluation of a Potential β-Secretase Inhibitor of 3-Hydroxyhericenone F from Hericium erinaceus

Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity

Therapeutic Potential of Hericium erinaceus for Depressive Disorder

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