Chemical constituents from Ficus natalensis hochst (Moraceae) and their chemophenetic significance

Mbougnia, Judith Flore Tchuissang; Happi, Gervais Mouthé; Bitchagno, Gabin Thierry M.; Awouafack, Maurice D.; Lenta, Bruno Ndjakou; Kouam, Siméon F.; Tane, Pierre; Sewald, Norbert; Téné, Mathieu

doi:10.1016/j.bse.2021.104227

Cited by 13 publications

(18 citation statements)

References 42 publications

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Section: Resultsmentioning

confidence: 99%

“…Compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) were isolated chromatographically, their structures were established using NMR and MS techniques and compared to related compounds in the literature (Figure 1). This includes 2-deethoxy-2β-hydroxyphantomolin (1) [5], 2β-methoxy-2-deethoxyphantomolin (2) [13], 2-deethoxy-8-O-deacylphantomolin-8-O-tiglinate (3) [14], 8-O-methacryloylelephantane (4) [5], 2,4-bis-O-methyl-8-O-methacryloy lelephantane (5), molephantin (6), molephantinin (7) [15], isochlorogenic acid (8) [16], 1,5-dicaffeoylquinic acid (9) [17], 4,5-dicaffeoylquinic acid (10) [17], apigenin (11) [18], luteolin (12) [19], tricin (13) [20], 2,6-dimethoxy-4-hydroxybenzoic acid ( 14) [21], 4-formylsyringol (15) [22], cryptomeridiol (16) 18) [24] and glycerine monopalmitate (19) [24].…”

Section: Resultsmentioning

confidence: 99%

“…The antibacterial activity of some isolated compounds was carried out by using the agar disk diffusion method to determine the diameter zone of inhibition (DZI) against five bacteria including two Gram-negative ( Escherichia coli DSMZ 1058 and Pseudomonas agarici DSMZ 11810) and three Gram-positive ( Micrococcus luteus DMSZ 1605, Staphylococcus warneri DSMZ 20036 and Bacillus subtilis DSMZ 704) strains [ 10 , 11 ]. The microorganisms were provided by DSMZ (German Collection of Microorganisms and Cell Cultures).…”

Section: Methodsmentioning

confidence: 99%

“…The cytotoxicity assay was performed with the human cervix carcinoma cell line KB-3-1 as previously reported [ 10 , 11 ]. The KB-3-1 cells were provided by DSMZ (number ACC 158) and cultivated as a monolayer in DMEM (Dulbecco’s modified Eagle medium) with glucose (4.5 g/L), L-glutamine, sodium pyruvate and phenol red, supplemented with 10% (KB-3-1) foetal bovine serum (FBS).…”

Section: Methodsmentioning

confidence: 99%

“…The results could be relevant in view of formulating the plant extract to relieve pains and diseases in less developing countries where the use of traditional medicine still prevails. The present study follows the ongoing research project dealing with the characterization of taxa with antibacterial and antiparasitic activities from Cameroonian rain forests and pharmacopeia [ 8 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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LC-ToF-ESI-MS Patterns of Hirsutinolide-like Sesquiterpenoids Present in the Elephantopus mollis Kunth Extract and Chemophenetic Significance of Its Chemical Constituents

et al. 2021

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A total of nine sesquiterpenoid lactones together with phenolic compounds and other terpenes were identified from the crude methanol extract of Elephantopus mollis Kunth. Compounds were isolated using different chromatographic techniques and their structures were determined by NMR and IR spectroscopy as well as mass spectrometry. The structures of some detected compounds were assigned based on LC-ToF-ESI-MS screening of main fractions/subfractions from flash chromatography and comparison with isolated analogues as standards. The findings revealed not only the in-source loss of water as the base peak in hirsutinolides but also the in-source loss of corresponding alcohol when the oxygen at position 1 is alkylated. The present study also draws up a complement of data with respect to hirsutinolide-like sesquiterpene lactones whose LC-MS characteristics are not available in the literature. The chemophenetic significance is also discussed. Some of the isolated compounds were reported for the first time to be found in the species, the genus as well as the plant family. The medium-polar fractions of the crude extract, also containing the larger amount of sesquiterpenoid lactones, exhibited activity both against a cancer cell line and bacterial strains. Isolated lactones were also active against the cancer cell line, while the chlorogenic derivatives also valuable in Elephantopus genus showed potent radical scavenging activity. This is the first report of cytotoxic and antibacterial activities of our samples against the tested strains and cell line. The present study follows the ongoing research project dealing with the characterization of taxa with antibacterial and antiparasitic activities from Cameroonian pharmacopeia.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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LC-ToF-ESI-MS Patterns of Hirsutinolide-like Sesquiterpenoids Present in the Elephantopus mollis Kunth Extract and Chemophenetic Significance of Its Chemical Constituents

et al. 2021

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Elemane‐Type Sesquiterpene, Acetonide Derived Polyacetylene and Other Constituents from the Whole Plant of Gymnanthemum theophrastifolium (Schweinf. ex Oliv. & Hiern) H.Rob. and Their Chemophenetic Significance

Tsakou

Ndontsa

Nono

et al. 2023

Chemistry & Biodiversity

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The chemical investigation of the methanol extract of the whole plant of Gymnanthemum theophrastifolium (Schweinf. ex Oliv. & Hiern) H.Rob. (Asteraceae) led to the isolation of a new elemane-type sesquiterpene (1), a new acetonide derived polyacetylene (2) and a naturally occurring compound (3) from the plant kingdom along with sixteen known compounds (4 -19). Their structures were elucidated by extensive NMR and MS analysis. This is the first report on the chemical constituents of G. theophrastifolium. Furthermore, compounds 12, 13, and 14 are reported for the first time from the family Asteraceae, while compound 9 is reported for the first time from the genus Gymnanthemum. Thus, the present results provide valuable insights to the chemophenetic knowledge of G. theophrastifolium, which is also discussed in this work.

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A new ceramide and other constituents from the fruits of Ficus lutea Vahl (Moraceae) and their chemotaxonomic significance

Fozeng

Donfack

Tchuenmogne

et al. 2023

Biochemical Systematics and Ecology

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Chemical constituents from Ficus natalensis hochst (Moraceae) and their chemophenetic significance

Cited by 13 publications

References 42 publications

LC-ToF-ESI-MS Patterns of Hirsutinolide-like Sesquiterpenoids Present in the Elephantopus mollis Kunth Extract and Chemophenetic Significance of Its Chemical Constituents

LC-ToF-ESI-MS Patterns of Hirsutinolide-like Sesquiterpenoids Present in the Elephantopus mollis Kunth Extract and Chemophenetic Significance of Its Chemical Constituents

Elemane‐Type Sesquiterpene, Acetonide Derived Polyacetylene and Other Constituents from the Whole Plant of Gymnanthemum theophrastifolium (Schweinf. ex Oliv. & Hiern) H.Rob. and Their Chemophenetic Significance

A new ceramide and other constituents from the fruits of Ficus lutea Vahl (Moraceae) and their chemotaxonomic significance

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