CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OF<i>Guettarda viburnoides</i>CHAM. &amp; SCHLTDL. (RUBIACEAE)

Naressi, Maria Augusta; Manholer, Daniele Domingos; Ames, Franciele Queiroz; Bersani-Amado, Ciomar Aparecida; Formagio, Anelise Samara Nazari; Pereira, Zefa Valdivina; Costa, Willian Ferreira da; Baldoqui, Débora Cristina; Sarragiotto, María Helena

doi:10.5935/0100-4042.20150093

Cited by 2 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results are in correspondence with the studies carried out by Gutiérrez et al (7). and those referred for the genus Guettarda (17)(18)(19)(20).…”

Section: Discussionsupporting

confidence: 92%

Phytochemical profile, acute dermal toxicity and wound healing activity of Guettarda calyptrata A. Rich

Gaitén

Norden

Lizama

et al. 2021

J Herbmed Pharmacol

View full text Add to dashboard Cite

Introduction: The leaves and barks of Guettarda calyptrata have been attributed to the property of healing wounds on the skin and mucous membranes. However, the scientific information about the phytochemical composition and biological properties is scarce. This research evaluates the chemical composition, dermal safety, and wound healing properties of a hydroalcoholic extract of G. calyptrata. Methods: Hydroalcoholic extract of G. calyptrata was obtained from leaves. The phytochemical profile was analyzed by phytochemical screening, thin layer chromatography, high performance liquid chromatography (HPLC), and quantification of phenols and flavonoids by Folin-Ciocalteu and aluminum chloride methods, respectively. An acute dermal toxicity test was performed in rats, and the healing activity was evaluated using the excision wound model at 100 mg/kg of the extracts. Statistical significance (P < 0.05) was determined by an analysis of variance followed by the Student-Newman-Keuls test. Results: The presence of alkaloids, saponins, terpenoids, phenolic compounds, rutin, and quercetin flavonoids, among others, was suggested. The extract did not cause toxicity at the dose of 2000 mg/kg and was able to reduce the size of the wounds during the seven days of the test, with a healing effect comparable to the silver sulfadiazine cream used as a positive control, favoring collagen deposition and re-epithelialization. Conclusion: This work makes an important contribution to the chemical composition and provides the first findings on the efficacy in the healing of topical wounds, which justify the use of G. calyptrata in traditional Cuban medicine.

show abstract

“…The results are in correspondence with the studies carried out by Gutiérrez et al (7). and those referred for the genus Guettarda (17)(18)(19)(20).…”

Section: Discussionsupporting

confidence: 92%

Phytochemical profile, acute dermal toxicity and wound healing activity of Guettarda calyptrata A. Rich

Gaitén

Norden

Lizama

et al. 2021

J Herbmed Pharmacol

View full text Add to dashboard Cite

show abstract

“…DPPH assay was performed on G. viburnoides leaves and on the G. uruguensis stem bark. Naressi et al (2015) showed higher antioxidant activity in G. viburnoides, with IC 50 rates for crude extract (24.69 µg mL ) were greatly capable of quenching the DPPH radical.…”

Section: Antioxidant Capacitymentioning

confidence: 95%

“…The flavonoids, namely, quercetin-3-O-B-Dgalactopyranoside, quercetin-3-O-B-D-glucopyranoside and grandifloroside (Naressi et al, 2015) and the phenolic acids, namely, 5-caffeoylquinic acid, 4,5-dicaffeoylquinic acid (Capasso et al, 1998, Oliveira et al, 2008, Testa et al, 2012 and shickimic acid (Capasso et al, 1998) were identified in the genus Guettarda. The literature also shows that 3,5-and 4,5-O-dicaffeoylquinic acids and 3-O-glucosilates derived from quercetin have significant scavenging abilities of free radicals, with IC50 rates close to those for FLA in the DPPH assay.…”

Section: Antioxidant Capacitymentioning

confidence: 98%

“…Phytochemical investigations on the genus revealed several compounds, including alkaloids (Kan-Fan and Husson, 1979;Capasso et al, 1998), iridoids (Inouye et al, 1988;Ferrari et al, 1986;Naressi et al, 2015), triterpenes (Aquino et al, 1988;Aquino et al, 1989;Bhattcharyya and Almeida, 1985) and other classes of substances, such as phenolic esters (Oliveira et al, 2008;Testa et al, 2012;Naressi et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of antioxidant capacity, phenolic content, antimicrobial and cytotoxic properties of Guettarda uruguensis flowers and fruits

Duarte¹,

Szabo²,

Duarte³

et al. 2016

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Antioxidant capacity, phenolic content, antimicrobial and cytotoxic properties of extracts and fractions from flowers and fruits of G. uruguensis were evaluated. Total phenolic content ranged between 406.8 ± 20.47 and 57.98 ± 1.734 gallic acid equivalent in mg g-1 (mg GAE g-1) samples. Ethyl acetate and butanol fractions from flowers had the greatest rates in phenolic content and antioxidant activity in 1,1diphenyl-2-picrylhydrazyl (DPPH) and thiobarbituric acid reactive substances (TBARS) assays. Pearson´s coefficient showed a strong association between total phenolic compounds in DPPH (r =-0.83, p < 0.01) and TBARS (r = 0.85, p < 0.01). Eleven out of the 12 samples tested were toxic in the brine shrimp assay (LC50 < 100 µg mL-1). Antimicrobial susceptibility profile revealed flower remaining fraction and fruit extract with moderate activity against Enterococcus faecalis. Results indicate that G. uruguensis is a good source of compounds with antioxidant and cytotoxic activities. Further studies to identify compounds causing these activities are recommended.

show abstract

CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OFGuettarda viburnoidesCHAM. & SCHLTDL. (RUBIACEAE)

Cited by 2 publications

References 0 publications

Phytochemical profile, acute dermal toxicity and wound healing activity of Guettarda calyptrata A. Rich

Phytochemical profile, acute dermal toxicity and wound healing activity of Guettarda calyptrata A. Rich

Evaluation of antioxidant capacity, phenolic content, antimicrobial and cytotoxic properties of Guettarda uruguensis flowers and fruits

Contact Info

Product

Resources

About