Chemical Constituents and Insecticidal Activity of <i>Rollinia leptopetala</i> (Annonaceae)

Arriaga, Ângela M. C.; Feitosa, Edinilza M.A.; Lemos, Telma L. G.; Santiago, Gilvandete Maria Pinheiro; Lima, Jefferson Queiroz; Oliveira, Maria C. F. de; Vasconcelos, Jackson Nunes e; Rodrigues, Francisco E. A.; Gomes, Tathilene B. M.; Braz‐Filho, Raimundo

doi:10.1177/1934578x0800301021

Cited by 7 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stigmasterol-3- O -β- d -glucopyranoside (AMrP1) was reported in the root of Polyalthia longifolia var pendula [ 25 ]. Lichexanthone (AMsbP1) had previously been isolated from the root of Rollinia leptopetala [ 26 ] and from the bark of Guatteria blepharophylla [ 27 ]. Gallic acid (AMsbP2) and β-sitosterol 3- O -β- d -glucopyranoside (AMsbP3) were recently found in the leaf of Polyalthia longifolia [ 28 ] and twig of Annona squamosa [ 29 ] respectively, all plants belonging to the Annonaceae family.…”

Section: Resultsmentioning

confidence: 99%

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum

et al. 2015

View full text Add to dashboard Cite

The aim of this work was to screen extracts from Annona muricata and Annona reticulata in vitro against Plasmodium falciparum. Crude ethanolic extracts, methylene chloride fractions, aqueous fractions, subfractions and isolated compounds (stigmasterol-3-O-β-d-glucopyranoside, lichexanthone, gallic acid and β-sitosterol-3-O-β-d-glucopyranoside) were tested for cytotoxicity on erythrocytes and Human Foreskin Fibroblasts cells and against the W2 strain of P. falciparum in culture. Results indicated that none of the extracts was cytotoxic at concentrations up to 10 µg/mL. Most of the extracts, fractions and subfractions inhibited the growth of P. falciparum with IC50 values ranging from 0.07 to 3.46 µg/mL. The most potent was the subfraction 30 from A. muricata stem bark (IC50 = 0.07 µg/mL) with a selectivity index of ˃ 142. Subfraction 3 from A. muricata root also exhibited very good activity (IC50 = 0.09 µg/mL) with a high selectivity index (SI ˃ 111). Amongst the isolated compounds, only gallic acid showed activity with IC50 of 3.32 µg/mL and SI > 10. These results support traditional claims for A. muricata and A. reticulata in the treatment of malaria. Given their limited cytotoxicity profile, their extracts qualify as promising starting points for antimalarial drug discovery.

show abstract

Section: Resultsmentioning

confidence: 99%

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The acetogenins that can be found in Annona cherimola have been the center of attention of many researchers because of their cytotoxic effect in different cancer lines [ 53 ], as well as for their tumoral and mitochondrial complex I inhibitory capacities [ 32 , 54 ]. In addition, these natural products have also exhibited antiparasitic [ 48 ], insecticidal [ 55 , 56 ] and bactericide [ 57 ] activity with really promising results.…”

Section: How To Apply Acgs From Annona Cherimola Millmentioning

confidence: 99%

“…Dimethyl sulphoxide is the most employed solvent in these tests, being applied either as co-solvent (1%) with water or as single solvent. Annonacin and molvizarin, obtained through this single solvent formulation, have been tested for larvicidal [ 56 ], anti-protist (leishmanicidal and trypanocidal) [ 61 ] and different insecticidal activities, such as oviposition capacity [ 13 ]. Apart from that, kidney studies with VERO cells have also been carried out on acetogenins combined with rollisniastatin-2 and on squamocin, where pure a DMSO solution was mixed with cell cultures [ 61 , 62 ].…”

Section: How To Apply Acgs From Annona Cherimola Millmentioning

confidence: 99%

An Overview of the Chemical Characteristics, Bioactivity and Achievements Regarding the Therapeutic Usage of Acetogenins from Annona cherimola Mill.

et al. 2021

View full text Add to dashboard Cite

Annona cherimola Mill., or the custard apple, is one of the species belonging to the Annonaceae family, is widely used in traditional medicine, and has been reported to be a valuable source of bioactive compounds. A unique class of secondary metabolites derived from this family are Annonaceous acetogenins, lipophilic polyketides considered to be amongst the most potent antitumor compounds. This review provides an overview of the chemical diversity, isolation procedures, bioactivity, modes of application and synthetic derivatives of acetogenins from A. cherimola Mill.

show abstract

“…From 2 to 9 m in height, its tree has elliptical to ovate leaves, with yellow, orange, or red apocarpous fruits, its flowering and fruiting ranges from November to April [ 47 ]. Bananinha is indicated in traditional medicine for the treatment of inflammation and tumors [ 48 ], and for its larvicidal potential [ 49 ], as well as its modulating effect on bacterial resistance to norfloxacin, in addition to a considerable antitumor effect in vivo [ 50 ]. The phytochemical study points to the presence of aporphine and tetrahydro-protoberberine alkaloids, in addition to acetogenins and a xanthone [ 51 ].…”

Section: Introductionmentioning

confidence: 99%

An Integrative Approach to the Flavonoid Profile in Some Plants’ Parts of the Annona Genus

Ramos

Mazzinghy

Correia

et al. 2022

Plants

View full text Add to dashboard Cite

The Annonaceae family is widely distributed in subtropical and tropical regions. Several species of this family are known for their pharmacological and beneficial properties to human health, mainly attributed to flavonoids. The objective of this work was to carry out an integrative review in order to identify the main flavonoids found in some plant parts belonging to the Annona genus: araticum tree (Annona crassiflora Mart.), graviola tree (Annona muricata), atemoya tree (Annona cherimolia Mill × Annona squamosa L.), pinha tree (Annona squamosa), bananinha tree (Annona leptopetala), and marolinho tree (Annona coriacea). Only articles published between the years 2016 to 2021 that answered the guiding question were considered, in order to obtain recent data. Then, search strategies were designated for each database used: Science Direct, CAPES Periodicals, and Scielo. Most of the studies retrieved from the databases are related to fruits. The results showed that the number of flavonoids identified varies according to the analytical methodology used to identify and quantify the compounds. Quercetin was the most commonly found compound in all fruits of the Annona genus studied, and epicatechin, rutin, and kaempferol were also found to a lesser extent. The presence of these compounds in Annona makes the fruit promising, with potential applicability in the pharmaceutical and food industry.

show abstract

Chemical Constituents and Insecticidal Activity of Rollinia leptopetala (Annonaceae)

Cited by 7 publications

References 12 publications

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum

An Overview of the Chemical Characteristics, Bioactivity and Achievements Regarding the Therapeutic Usage of Acetogenins from Annona cherimola Mill.

An Integrative Approach to the Flavonoid Profile in Some Plants’ Parts of the Annona Genus

Contact Info

Product

Resources

About