Chemical constituents and biological activity of three Tanzanian wild mushroom species

Baraza, Lilechi D.; Joseph, Cosam C.; Moshi, Mainen J.; Nkunya, Mayunga H.H.

doi:10.4314/tjs.v33i1.44280

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…The above IR spectrum was consistent with reported data as described by Pavia et al [17]. Compound 1 compared well with the reported data for compound (2) with only different at the coupling constant values (J values) at C-22 and C-23 (J value of 15.6Hz) [11,16,17]. Table 3.…”

supporting

confidence: 91%

“…This compound was identified as Ergosta-5, 7, 22-triene-3β, 14αdiol (22Z), with molecular formula C 28 H 45 O 2 by combined spectroscopic analysis ( 1 H-NMR, 13 C-NMR and HMBC). C-NMR spectra and in comparison with observed data of similar structures [11,16,17,18] showed that most peaks were consistent with Ergosta-5,7,22-triene-3β,14α-diol (22Z). [17], coupling constant for cis molecule occurs in the range of 6 -10Hz, while trans-isomers have been reported with J-values between 11 -18Hz.…”

Section: Spectral Analysis Ergosta-5722triene-3β14α-diol (22z)(1)mentioning

confidence: 81%

“…Further bioactivity studies with higher concentration may reveal the actual concentration that the compound may inhibit against P. aeruginosa, K. pneumoniae and E. coli. Other researchers have also revealed that ergosterol from G. lucidum has been used by traditional healers in the treatment of malaria [23] and has also proved to be toxic against brine shrimp larvae [16].…”

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confidence: 99%

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Isolation, Characterization and Antibacterial Activity of Ergosta-5, 7, 22-triene-3β, 14α – diol (22Z) from Kenyan Ganoderma lucidum

Sande

Baraza

Ooko

et al. 2020

AJACR

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Aims: To determine the chemical composition and antibacterial activity of Kenyan Ganoderma lucidum. Study Design: Structural determination of the isolated compound was done using spectral evidences and in comparison with literature. The antibacterial properties of the compound was done using disc diffusion method. Place and Duration of Study: Department of Pure and Applied Chemistry, Masinde Muliro University of Science and Technology, between January and November, 2019. Methodology: Sequential extraction of dried samples of Kenyan G. lucidum were done using solvents hexane, ethyl acetate and methanol. Chromatographic separation of hexane extract of Ganoderma lucidum was done using spectroscopic data. The compound was assayed against Escherichia coli, Klebsiella pneumoniae, Methicillin–Resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and Streptococcus pyogenes. Standard antibiotic namely; ampicillin was used as the control. Disc diffusion method was used and zones of inhibition, after respective incubation periods, were used to quantify antibacterial activity. Results: From hexane extract of Ganoderma lucidum, Ergosta-5, 7, 22-triene-3β, 14α – diol (22Z) was isolated. Ethylacetate and methanol extracts produced a mixture of complex compounds. Ergosta-5,7,22-triene-3β,14α-diol (22Z) exhibited significant activity against Methicillin-Resistance Staphylococcus aureus (MRSA) (p=0.022) and Streptococcus pyogenes (p = 0.05). The most sensitive microbe was Streptococcus pyogenes. Conclusion: One major compound, Ergosta-5, 7, 22-triene-3β, 14α – diol (22Z) was isolated, characterized and antibacterial activity determined.

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supporting

confidence: 91%

Section: Spectral Analysis Ergosta-5722triene-3β14α-diol (22z)(1)mentioning

confidence: 81%

mentioning

confidence: 99%

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Isolation, Characterization and Antibacterial Activity of Ergosta-5, 7, 22-triene-3β, 14α – diol (22Z) from Kenyan Ganoderma lucidum

Sande

Baraza

Ooko

et al. 2020

AJACR

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“…Phytochemicals such as alkaloid, steroid, triterpenoids, fl avonoid, anthracene, saponins, tannins and glycosides are also found in Termitomyces reticulatus (Loganathan et al 2010). Similarly, fatty acids in Termitomyces clypeatus (Baraza et al 2007) and Termitomyces letestui their essential fatty acids are required for the promotion of a variety of body biochemical function. These are potential nutritional food for individuals susceptible to diabetes (Arasmus 1995).…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Screening of Termite's Mushroom in Nepal

Aryal

Budhathoki

2015

J. Nat. Hist. Mus.

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This paper reports the qualitative phytochemical analysis of Termitomyces microcarpus (Berk & Broome) R. Heim of family Tricholomataceae collected from the termite nest of the forests in west, center and east of tropical, subtropical and temperate regions of Nepal. The sample was harvested fresh, sundried, pulverized and analyzed according to standard procedures. Screening revealed the presence of volatile oil, alkaloid, carotenoid, steroid, triterpenoids, fatty acid, emodins, fl avonoid, coumarin, anthracene glycoside, anthocyanadine glycoside, tannins, saponins, glycosides, polyurenoid and polyoses in the ethereal, methanolic and aqueous extracts. There were signifi cant differences in the phytochemical composition of the samples collected from east, center and west eco-zones and tropical, subtropical and temperate climatic regions. There was defi nite co-relation between the traditional application of Termite's mushrooms and possession of secondary metabolites, which supports the scientifi c basis for the traditional medicinal system. Results showed that the consumption of wild edible mushroom that act as a good dietary supplement and it may be valuable in drug development.

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“…quinquefasciatus and Ae. aegypti [ 99 ]. The larvicidal activity of methanolic extract of G. lucidum against fourth instar larvae of Cx.…”

Section: Biocontrol Properties Of Basidiomycetesmentioning

confidence: 99%

Biocontrol Properties of Basidiomycetes: An Overview

Sivanandhan¹,

Khusro²,

Paulraj³

et al. 2017

JoF

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In agriculture, there is an urgent need for alternate ecofriendly products to control plant diseases. These alternate products must possess preferable characteristics such as new modes of action, cost effectiveness, biodegradability, and target specificity. In the current scenario, studies on macrofungi have been an area of importance for scientists. Macrofungi grow prolifically and are found in many parts of the world. Basidiomycetes (mushrooms) flourish ubiquitously under warm and humid climates. Basidiomycetes are rich sources of natural antibiotics. The secondary metabolites produced by them possess antimicrobial, antitumor, and antioxidant properties. The present review discusses the potential role of Basidiomycetes as anti-phytofungal, anti-phytobacterial, anti-phytoviral, mosquito larvicidal, and nematicidal agents.

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Chemical constituents and biological activity of three Tanzanian wild mushroom species

Cited by 5 publications

References 24 publications

Isolation, Characterization and Antibacterial Activity of Ergosta-5, 7, 22-triene-3β, 14α – diol (22Z) from Kenyan Ganoderma lucidum

Isolation, Characterization and Antibacterial Activity of Ergosta-5, 7, 22-triene-3β, 14α – diol (22Z) from Kenyan Ganoderma lucidum

Phytochemical Screening of Termite's Mushroom in Nepal

Biocontrol Properties of Basidiomycetes: An Overview

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