Chemical constituents and biological activities from roots of<i>Enkleia siamensis</i>

Rajachan, Oue-artorn; Kanokmedhakul, Somdej; Nasomjai, Phitak; Kanokmedhakul, Kwanjai

doi:10.1080/14786419.2013.838241

Cited by 8 publications

(2 citation statements)

References 13 publications

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“…Therefore, it is urgent to find novel and effective candidates to enhance the therapeutic effect of breast cancer. Daphnoretin has been shown to exert antitumor activity to colon cancer HCT116 cells, cervical cancer HeLa cells, oral epidermoid carcinoma KB cells, lung cancer A549 cells, and NCI-H187 cells. ,− In this study, we found that daphnoretin could remarkably suppress breast cancer cell proliferation through arresting the cell cycle and inducing cell apoptosis, which is related to the PI3K/AKT pathway.…”

Section: Discussionmentioning

confidence: 72%

“…Further studies demonstrated that daphnoretin remarkably induced apoptosis through a mitochondria-dependent apoptotic pathway . Furthermore, several studies have revealed that daphnoretin showed powerful cytotoxicity to lung cancer A549 cells, NCI-H187 cells, and oral epidermoid carcinoma KB cells. , However, the therapeutic effect of daphnoretin in breast cancer has still not been completely studied.…”

Section: Introductionmentioning

confidence: 99%

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Daphnoretin Arrests the Cell Cycle and Induces Apoptosis in Human Breast Cancer Cells

Xie¹,

Fan

Han³

et al. 2022

J. Nat. Prod.

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Emerging evidence has shown that daphnoretin, one of the main active ingredients of Daphne giraldii Nitsche, processes antitumor activities in several tumor cells (e.g., colon cancer, lung cancer, cervical cancer, and osteosarcoma). However, the antitumor effect and its mechanism in breast cancer are unexplored. In this study, our data indicated that daphnoretin obviously suppressed the proliferation of breast cancer MCF-7 and MDA-MB-231 cells. Further studies showed that daphnoretin remarkably increased the p21 level, decreased cyclin E and CDK2 levels, and then arrested the cell cycle at the S phase. Moreover, daphnoretin obviously lowered the BCL-2 level and raised the levels of BAX and cleaved caspase-9 and -3, leading to cell apoptosis. Furthermore, daphnoretin remarkably decreased the ratio of p-PI3K/PI3K and p-AKT/AKT in breast cancer cells. Collectively, these findings demonstrated that daphnoretin could suppress breast cancer cell proliferation through cell cycle arrest and inducing apoptosis, which is related to the PI3K/AKT pathway.

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Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Daphnoretin Arrests the Cell Cycle and Induces Apoptosis in Human Breast Cancer Cells

Xie¹,

Fan

Han³

et al. 2022

J. Nat. Prod.

View full text Add to dashboard Cite

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Progress in the Chemistry of Naturally Occurring Coumarins

Sarker

Nahar

2017

Progress in the Chemistry of Organic Natural Products

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Coumarins are the largest group of 1-benzopyran derivatives found in plants. The initial member of this group of compounds, coumarin (2H-1-benzopyran-2-one), a fragrant colorless compound, was first isolated from the Tonka bean (Dipteryx odorata, family Fabaceae) in 1820. The name coumarin comes from a French term for the tonka bean, coumarou. Since the discovery of coumarin, several of its derivatives, with umbelliferone (7-hydroxycoumarin) being the most common one, have been reported from various natural sources. The families Apiaceae, Asteraceae, and Rutaceae are the three major plant sources of coumarins.Generally, these plant secondary metabolites may be classified into simple, simple prenylated, simple geranylated, furano, pyrano, sesquiterpenyl and oligomeric coumarins. Using this standard classification, this chapter aims to present an account on the advances of the chemistry of naturally occurring coumarins, as reported in the literature during the period 2013-2015.In Sect. 1, the coumarins are introduced and their generic biosynthetic route discussed briefly. In Sect. 2, the largest of the three sections, various classes of natural coumarins are detailed, with their relevant structures and the citation of appropriate references. In a concluding section, it is highlighted that during the last 3 years, more than 400 coumarins have been reported in the literature. Many of these coumarins have been re-isolations of known compounds from known or new sources, most often associated with various biological activities. However, a substantial number of coumarins bearing new skeletons, especially dimers, prenylated furanocoumarins, sesquiterpenyl, and some unusual coumarins were also reported during the period of 2013-2015.Coumarin chemistry remains one of the major interest areas of phytochemists, especially because of their structural diversity and medicinal properties, along with the wide-ranging bioactivities of these compounds, inclusive of analgesic, anticoagulant anti-HIV, anti-inflammatory, antimicrobial, antineoplastic, antioxidant, and immunomodulatory effects. Despite significant advancements in the extraction, isolation, structure elucidation and bioactivity testing of naturally occurring coumarins, only a marginal advancement has been observed recently in relation to the study of their biosynthesis.

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