Chemical constituents and antioxidant activity of Garcinia madruno (Kunth) Hammel

Ramirez, Cesar; Gil, José; Marín-Loaiza, J. Camilo; Rojano, Benjamín Alberto; Durango, Diego

doi:10.1016/j.jksus.2018.07.017

Cited by 7 publications

(7 citation statements)

References 38 publications

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“…The antioxidant activity determined as DPPH IC 50 values exhibited the lowest value in the peel (0.094 µg/ml) and the pulp (0.750 µg/ml), suggesting that these two fractions have higher antioxidant activity. The DPPH IC 50 values are similar to those reported for the methanolic extract of G. madruno and mangosteen fruit (Ramirez et al, 2018). Consistent with this, the peel exhibited higher ABTS+ antioxidant activity values (488.564 mg TE/g), followed by the pulp (182.623 mg TE/g) and the aril (118.836 mg TE/g), suggesting that the components present in the peel contribute to antioxidant activity.…”

Section: Antioxidant Propertiessupporting

confidence: 85%

“…Similarly, the pulp exhibited a higher concentration of anthocyanins (0.90 mg C3G/g) than that determined for the peel. All samples exhibited a total polyphenols content greater than that reported in methanolic extracts of other fruits belonging to the same family, such as Garcinia madruno (Kunth) Hammel (Ramirez et al, 2018). In contrast, the aril exhibited higher values of total carotenoids (0.915 µg/g) and vitamin C (60.771 mg AA/g) compared to the pulp and peel samples.…”

Section: Antioxidant Propertiesmentioning

confidence: 67%

“…Numerous studies have shown that the genus Clusia L. is a rich source of polyisoprenylated benzophenones and other compounds such as flavonoids and terpenes (Ribeiro et al, 2011). Many of the metabolites present in the flowers, fruits, leaves, and latex of different species of Clusia have antimicrobial, anti-HIV, and antioxidant activity (Huerta-Reyes et al, 2004;Ribeiro et al, 2011;Ramirez et al, 2018;Singh et al, 2020). Their use has been reported in the treatment of symptoms of weakness, constipation, and diarrhea, as well as for leprosy and scarring, and as a cough remedy (Mattos-Silva et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Bioactive compounds, antioxidant and antibacterial properties of the pulp, peel and aril of the fruit of Clusia quadrangula (Clusiaceae)

Martínez-Mendoza,

Juárez-Trujillo,

Mendoza-López

et al. 2023

Acta Bot. Mex.

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Background and Aims: The Clusiaceae family is known for its bioactive compounds with beneficial antioxidant and anti-inflammatory properties. The objectives of this study were to 1) identify and quantify the individual polyphenol compounds in the methanolic extract from peel, pulp and aril of the fruit of Clusia quadrangula by UPLC-MSMS, evaluate their antioxidant properties, 2) analyze the fatty acid profile, minerals composition and 3) determine the antibacterial activity against pathogenic bacteria of the methanolic extract.Methods: Physicochemical properties, antioxidants and bioactive compounds, fatty acid profile and mineral content were analyzed using a Microplate Spectrophotometer, Ultra High Performance Liquid Chromatography coupled with a triple quadrupole Mass Spectrometer, Gas Chromatography coupled with a Mass Spectrometer and Microwave Plasma Atomic Emission Spectroscopy.Key results: Twenty phenolic compounds were identified and quantified plus the precursor shikimic acid (103.55 µg/g solids). Procyanidin B2 (41.56 µg/g solids), (−)-epicatechin (34.07 µg/g solids), and ellagic acid (27.58 µg/g solids) were found in greater quantity in the methanolic extract of the pulp. Palmitic and linoleic acid were the most abundant fatty acids in the pulp, peel, and aril, and linolenic acid was present in the pulp. The pulp also exhibited the highest amount of total polyphenolic compounds (24.33 mg GAE/g) and reducing power evaluated by FRAP (18.697 mg ET/g). Analysis of the minerals revealed that all fractions are rich in magnesium, potassium, sodium, and calcium. The results showed that the methanolic extract of the different parts of the fruit had antibacterial properties against Salmonella typhi, Escherichia coli, Staphylococcus aureus, and Enterococcus faecalis. Conclusions: These results indicate that different parts of the C. quadrangula fruit are a rich source of natural antioxidants and possess antibacterial properties. Therefore, it can be considered for use as ingredient or additive in the cosmetic, pharmaceutical, or food industries.

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Section: Antioxidant Propertiessupporting

confidence: 85%

Section: Antioxidant Propertiesmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

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Bioactive compounds, antioxidant and antibacterial properties of the pulp, peel and aril of the fruit of Clusia quadrangula (Clusiaceae)

Martínez-Mendoza,

Juárez-Trujillo,

Mendoza-López

et al. 2023

Acta Bot. Mex.

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“…This implies the phenolic compounds in the root bark of G. celebica were mostly nonpolar and semi-polar. This fact was supported by Ramirez et al, who reported the high TPC value of n-hexane extract of epicarp and leaves of G. madruno [37]. Additionally, Menon et al proved that some xanthones were isolated from the n-hexane extract of G. wightii [38].…”

Section: Total Phenolic and Flavonoid Contents Of The G Celebica Extractsmentioning

confidence: 77%

Biological Activity Evaluation and In Silico Studies of Polyprenylated Benzophenones from Garcinia celebica

et al. 2021

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This study aimed to isolate polyprenylated benzophenones from the rootbark of Garcinia celebica and assess their activities in vitro and in silico. The antioxidant activity was evaluated by the DPPH, ABTS, and FRAP methods. The cytotoxicity was evaluated against HeLa, MCF-7, A549, and B16 cancer cell lines. The antiplasmodial activity was performed against the chloroquine-sensitive Plasmodium falciparum strain 3D7. Molecular docking was analyzed on alpha-estrogen receptor (3ERT) and P. falciparum lactate dehydrogenase enzyme (1CET). The prediction of ADMET for the compounds was also studied. For the first time, (-)-cycloxanthochymol, isoxanthochymol, and xanthochymol were isolated from the root bark of Garcinia celebica. The antioxidant and cytotoxicity evaluation showed that all benzophenones exhibited antioxidant activity compared to gallic acid and quercetin as positive controls and also exhibited strong activity against HeLa, MCF-7, A549, and B16 cell lines compared to cisplatin as the positive control. The antiplasmodial evaluation showed that isoxanthochymol exhibited activity against the chloroquine-sensitive P. falciparum strain 3D7. In addition, the in silico molecular docking study supported in vitro activities. The ADMET analysis also indicated the isolated benzophenones are potential oral drug candidates.

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“…"Rose-kandis" was discovered to be grown only in Sabah (16). Plants of Garcinia are primarily found in lowland tropical forests (18). They are evergreen plants, varying in size from small to medium.…”

Section: Introductionmentioning

confidence: 99%

Essential Oils of Garcinia spp. and Their Biological Activities

Tan,

Azizi,

Che Omar

et al. 2023

MJMHS

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Garcinia is the largest genus in the Clusiaceae family. Plants of Garcinia are widely distributed in Africa, Asia, Australia, Central America, Madagascar, and Polynesia. There are over 400 species of Garcinia found in the lowland tropical forests. Garcinia are known for their medicinal values due to the presence of biologically active constituents. Plants with medicinal values play a key role in human health and disease prevention. Plant-based natural products such as essential oils (EOs) have been employed for centuries owing to their beneficial effects. Generally, EOs are a mixture of volatile chemical constituents comprising mainly terpenoids and phenylpropanoids. They play diverse roles as biologically active agents. To date, EOs have found wide applications in pharmaceutical, food, flavour and fragrance. This review discusses the volatile chemical constituents of EOs extracted from different plant parts of Garcinia. The biological activities of Garcinia EOs are highlighted to explore their therapeutic potential.

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Chemical constituents and antioxidant activity of Garcinia madruno (Kunth) Hammel

Cited by 7 publications

References 38 publications

Bioactive compounds, antioxidant and antibacterial properties of the pulp, peel and aril of the fruit of Clusia quadrangula (Clusiaceae)

Bioactive compounds, antioxidant and antibacterial properties of the pulp, peel and aril of the fruit of Clusia quadrangula (Clusiaceae)

Biological Activity Evaluation and In Silico Studies of Polyprenylated Benzophenones from Garcinia celebica

Essential Oils of Garcinia spp. and Their Biological Activities

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