Chemical constituents and allelopathic and antioxidant activities of <i>Alchorneopsis floribunda</i> Müll. Arg. (Euphorbiaceae)

Batista, Elenilze F.; Costa, Danielle Monteiro; Guilhon, Giselle Maria Skelding Pinheiro; Müller, Adolfo Henrique; Santos, Lourivaldo S.; Arruda, Mara Silvia Pinheiro; Arruda, Alberto C.; Silva, Milton Nascimento; Silva, Joyce Kelly; Secco, Ricardo de S.; Filho, A.P.S. Souza; Figueira, Bruno Apolo Miranda

doi:10.1080/14786419.2011.643549

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…For instance Capsicum frutescens is used in management of different cancers – an activity attributed to presence of capsaicin which possesses antimutagenic and anticarcinogenic activities [ 61 ]. Also Prunus africana has been found to possess anti-inflammatory and antioxidative activities and compounds like cytotoxic phenolics and beta sitostenone, n-docosanol [ 62 ] which are important in management of cancer. The ethnomedicinal reports of the same plant species across geographical regions and different cultural groups is indicative of the medicinal properties of the species.…”

Section: Discussionmentioning

confidence: 99%

Ethnobotanical survey of medicinal plant species used by communities around Mabira Central Forest Reserve, Uganda

Tugume

Kakudidi

Buyinza

et al. 2016

J Ethnobiology Ethnomedicine

266

244

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BackgroundAn ethnobotanical study of medicinal plants was carried out in 14 villages adjacent to Mabira Central Forest Reserve (CFR) in Central Uganda between August 2013 and March 2014.MethodsInformation was obtained through interviews using semi- structured questionnaires. Field excursions with traditional healers and herbal medicine collectors were carried out. Descriptive statistics were used to present the data. Fidelity ratios and Informant consensus agreements were calculated.ResultsA total of 190 plant species in 61 families and 152 genera were reported in the treatment of various health conditions. Family Fabaceae was dominant representing 14 % of the plant species documented. Vernonia amygdalina was the preferred species for treating malaria. Leaves (68 %) were the most frequently used parts in preparing herbal remedies. Decoctions (29 %) and oral route (53 %) of administration were commonly used method of herbal medicine preparation and administration respectively. Fifty-eight health conditions grouped in 25 categories were treated using medicinal plants. Informant consensus agreement was highest for blood system disorders (0.9) that included anaemia, hypertension and blood cleansing indicating homogeneity of informant’s knowledge about remedies used. Vernonia amygdalina and Erythrina abyssinica had 100 % fidelity level for treatment of malaria and vomiting respectively.ConclusionThe diversity of medicinal plant species used and the associated indigenous knowledge are of great value to the local community and their conservation and preservation is paramount. The therapeutic uses of the documented plants provides basic data for further research focused on pharmacological studies and conservation of the most important species.

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Section: Discussionmentioning

confidence: 99%

Ethnobotanical survey of medicinal plant species used by communities around Mabira Central Forest Reserve, Uganda

Tugume

Kakudidi

Buyinza

et al. 2016

J Ethnobiology Ethnomedicine

266

244

View full text Add to dashboard Cite

show abstract

“…Fraction E3-1 (625 mg) was subjected to Sephadex LH-20 column chromatography (φ 2 × 80 cm) with MeOH/H 2 O (1 : 1, v/v) and then purified by RP-HPLC to yield compound 1 (14.71 mg) and compound 2 (14.28 mg). 6), 45 apigenin-7-O-β-D-glucopyranoside ( 7), 46 47 gallic acid (9), 48 protocatechuic acid (10), 49 and corilagin ( 11) 50 (Fig. 1).…”

Section: Extraction and Isolationmentioning

confidence: 99%

Bioactive compounds of Eriocaulon sieboldianum blocking proliferation and inducing apoptosis of HepG2 cells might be involved in Aurora kinase inhibition

Fan

et al. 2015

Food Funct.

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Eriocaulon sieboldianum (Sieb. & Zucc. ex Steud.) is an edible and medicinal plant used in traditional Chinese medicine. Often in combination with other herbs, it is processed into healthcare beverages for expelling wind-heat, protecting eyes, and reducing blood lipids. Besides, its water decoction together with other herbs has been utilized to treat cancer in China. However, the active ingredients and the precise cellular mechanisms of E. sieboldianum remain to be elucidated. The Aurora kinase family plays critical roles in the regulation of cell division and has attracted great attention to the identification of small-molecule Aurora kinase inhibitors for potential treatment of cancer. A molecular docking study was employed for docking of the most bioactive compounds. Hispidulin (HPDL) and quercetin-3-O-(6''-O-galloyl)-β-D-galactopyranoside (QGGP) were singled out as potent inhibitors of Aurora kinase. Their inhibitory activity towards Aurora kinase was further confirmed by the obvious decrease in autophosphorylation of Aurora-A (Thr288) and Aurora-B (Thr232). Moreover, the induction of cell cycle arrest in HepG2 cells and the suppressed phosphorylation of histone H3 were also consistent with the inhibition of Aurora kinase. The data indicate that the E. sieboldianum extract and its two active compounds, HPDL and QGGP, could effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways. These findings could improve the understanding and enhance the development of drugs based on E. sieboldianum and raise its application value in anticancer therapy or prevention. In addition, our results indicated that Aurora kinase might be a novel target of HPDL and QGGP.

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“…Coincidentally, Rawat et al (1998) found that Prunus armeniaca, a common tree species containing rich condensed tannins (CTs), significantly inhibited the growth and development of wheat at an exaggerated distance of 6.5 m [26]. Additionally, the major phytochemical compound in leaves and stems of Alchroneopsis floribunda (an endemic tree in Amazon) is ellagitannin, which exerted a strong allelopathic effect on Mimosa pudica seeds [27]. Nevertheless, CTs acting as bioactive allelopathic compounds in mangrove forests have not been investigated elsewhere.…”

Section: Introductionmentioning

confidence: 99%

Microcosm Study on Allelopathic Effects of Leaf Litter Leachates and Purified Condensed Tannins from Kandelia obovata on Germination and Growth of Aegiceras corniculatum

Lang

Wei

Chen

et al. 2021

Forests

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Kandelia obovata (Ko) and Aegiceras corniculatum (Ac) are common and dominant plant species in mangrove wetlands in South China, which are distributed in similar tidal zones along the coastline. The present study aimed to determine the allelopathic effects of leaf litter leachates (LLLs) from Ko and their purified condensed tannins (PCTs) on the germination and growth of Ac by mangrove microcosms. Replicate pots containing five different levels of LLLs and PCTs were separately prepared and propagules of Ac were placed in each treatment. Both LLLs and PCTs significantly inhibited the germination and growth of Ac, especially at high concentrations. The final germination rates of the roots and stems and the numbers of fine roots declined continuously, while other growth indicators, including the lengths of fine roots and nutritive roots and the biomasses of roots, stems, and leaves first increased and then decreased with increasing levels. These results indicate that LLLs from the leaf litter of Ko, in particular their PCTs, exerted an inhibition effect on propagule germination and seedling growth of Ac, and the inhibitory effects were concentration dependent. This study suggested that condensed tannins from leaf litter, acting as allelochemicals, could regulate the natural regeneration of a mangrove forest.

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Chemical constituents and allelopathic and antioxidant activities of Alchorneopsis floribunda Müll. Arg. (Euphorbiaceae)

Cited by 10 publications

References 25 publications

Ethnobotanical survey of medicinal plant species used by communities around Mabira Central Forest Reserve, Uganda

Ethnobotanical survey of medicinal plant species used by communities around Mabira Central Forest Reserve, Uganda

Bioactive compounds of Eriocaulon sieboldianum blocking proliferation and inducing apoptosis of HepG2 cells might be involved in Aurora kinase inhibition

Microcosm Study on Allelopathic Effects of Leaf Litter Leachates and Purified Condensed Tannins from Kandelia obovata on Germination and Growth of Aegiceras corniculatum

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