Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells

Timalsina, Shikshya; Arimoto-Matsuzaki, Kyoko; Kitamura, Masami; Xu, Xiaoyin; Qiu, Wenzhe; Ishigami‐Yuasa, Mari; Kagechika, Hiroyuki; Hata, Yoshinobu

doi:10.1093/jb/mvy062

Cited by 33 publications

(37 citation statements)

References 29 publications

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“…They have all been reported to induce the formation of SGs in vitro [ 4 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. It is surmised that SGs are transient triage centers that are designed to help cells to quickly and transiently modify translation to overcome stress and enhance survival, both of which could be used to escape cancer therapies [ 17 , 18 , 19 ].…”

Section: Generalitiesmentioning

confidence: 99%

“…In some cases, SGs pro-survival role might not be beneficial for the host, such as in the context of cancer. Cancer cells are frequently, if not systematically, exposed to stresses, such as hypoxia and nutrient deprivation, two stressors able to induce the formation of SGs [ 10 ] and promote resistance to therapies, which suggest a pro-survival role of SGs in this context [ 18 ]. Chemotherapies (CT) can also induce SGs formation [ 11 , 12 , 14 , 15 , 16 , 52 ].…”

Section: Stress Granules Are Involved In Cancer Progressionmentioning

confidence: 99%

“…A screen of small molecules revealed that β-estradiol, progesterone and stanolone prevent SGs formation and restore the sensitivity to CT in HeLa cells [ 18 ]. The same molecules used in the MCF7 breast cancer cell line did not block SGs formation, or the chemoresistance induction, suggesting a cell-specific effect of these molecules on SGs [ 16 , 18 ]. The ability to block SGs formation seems to vary from patient-to-patient, just as treatment response.…”

Section: Stress Granules Are Involved In Cancer Progressionmentioning

confidence: 99%

“…The ability to block SGs formation seems to vary from patient-to-patient, just as treatment response. Overall, this study suggests that blocking SGs formation in cancer may be an interesting option against cancer cells, provided that a compound targeting SGs and able to overcome the patient/tissue heterogeneity could be found [ 18 ].…”

Section: Stress Granules Are Involved In Cancer Progressionmentioning

confidence: 99%

“…A growing tumor is an extremely dynamic environment where stressors, such as mechanical constriction, hypoxia and/or starvation (nutrient and/or glucose) play a role at multiple levels. SGs could play a critical role in integrating these stressors into changes in translation that leads to cancer progression [ 18 , 51 ]. Recent studies have demonstrated that such changes occur after exposure to hypoxia stress [ 18 , 54 , 55 , 56 ].…”

Section: Stress Granules Are Involved In Cancer Progressionmentioning

confidence: 99%

See 4 more Smart Citations

Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins?

Aulas

Finetti

Lyons

et al. 2020

Cancers

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Cancer treatments are constantly evolving with new approaches to improve patient outcomes. Despite progresses, too many patients remain refractory to treatment due to either the development of resistance to therapeutic drugs and/or metastasis occurrence. Growing evidence suggests that these two barriers are due to transient survival mechanisms that are similar to those observed during stress response. We review the literature and current available open databases to study the potential role of stress response and, most particularly, the involvement of Stress Granules (proteins) in cancer. We propose that Stress Granule proteins may have prognostic value for patients.

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Section: Generalitiesmentioning

confidence: 99%

Section: Stress Granules Are Involved In Cancer Progressionmentioning

confidence: 99%

Section: Stress Granules Are Involved In Cancer Progressionmentioning

confidence: 99%

Section: Stress Granules Are Involved In Cancer Progressionmentioning

confidence: 99%

Section: Stress Granules Are Involved In Cancer Progressionmentioning

confidence: 99%

See 3 more Smart Citations

Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins?

Aulas

Finetti

Lyons

et al. 2020

Cancers

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Emetine‐Loaded Black Phosphorus Hydrogel Sensitizes Tumor to Photothermal Therapy through Inhibition of Stress Granule Formation

Xie

Fan

Kim

et al. 2020

Adv Funct Materials

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During photothermal therapy (PTT), hyperthermia up to 50 °C is required for efficient induction of tumor cell death. Additional increases in temperature can lead to severe damage to adjacent tissues. Conversely, insufficient heating of deep-seated tumor tissues results in tumor recurrence. Sensitization of tumor cells to PTT may solve this problem. Stress granules (SGs) function in integration of various internal and external stresses to regulate cell viability. However, the role of SGs in PTT is currently unknown. Here, with black phosphorus (BP) nanosheets as photothermal agents, it is found that SGs are induced in tumor by PTT through eukaryotic initiation factor 2α-dependent pathway and participate in tumor resistance to PTT. To modulate SG formation in tumor, a BP hydrogel is prepared for tumor-specific delivery and near-infrared (NIR) light-controlled release of the SG inhibitor Emetine. Upon NIR-light irradiation, photothermal conversion of BP nanosheets enables PTT of tumor. Meanwhile, light-controlled release of Emetine in tumor tissues effectively inhibits PTT-induced SG formation and sensitizes tumor to PTT, resulting in enhanced tumor inhibition. These results reveal the role of SGs in PTT and present a novel strategy for tumor sensitization to enhance the therapeutic efficacy and reduce the side effects of PTT.

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Role of stress granules in modulating senescence and promoting cancer progression: Special emphasis on glioma

Chatterjee

Chakrabarti

2021

Intl Journal of Cancer

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Stress granules (SGs) contain mRNAs and proteins stalled in translation during stress; these are increasingly being implicated in diseases, including neurological disorders and cancer. The dysregulated assembly, persistence, disassembly and clearance of SGs contribute to the process of senescence. Senescence has long been a mysterious player in cellular physiology and associated diseases. The systemic process of aging has been pivotal in the development of various neurological disorders like age‐related neuropathy, Alzheimer's disease and Parkinson's disease. Glioma is a cancer of neurological origin with a very poor prognosis and high rate of recurrence, SGs have only recently been implicated in its pathogenesis. Senescence has long been established to play an antitumorigenic role, however, relatively less studied is its protumorigenic importance. Here, we have evaluated the existing literature to assess the crosstalk of the two biological phenomena of senescence and SG formation in the context of tumorigenesis. In this review, we have attempted to analyze the contribution of senescence in regulating diverse cellular processes, like, senescence associated secretory phenotype (SASP), microtubular reorganization, telomeric alteration, autophagic clearance and how intricately these phenomena are tied with the formation of SGs. Finally, we propose that interplay between senescence, its contributing factors and the genesis of SGs can drive tumorigenicity of gliomas, which can potentially be utilized for therapeutic intervention.

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Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells

Cited by 33 publications

References 29 publications

Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins?

Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins?

Emetine‐Loaded Black Phosphorus Hydrogel Sensitizes Tumor to Photothermal Therapy through Inhibition of Stress Granule Formation

Role of stress granules in modulating senescence and promoting cancer progression: Special emphasis on glioma

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