CHEMICAL COMPOSITIONS AND BIOLOGICAL PROPERTIES OF ESSENTIAL OILS FROM ZANTHOXYLUM RHETSA (ROXB.) DC AND ZANTHOXYLUM LIMONELLA ALSTON. Pg

Wongkatiya, Nalin; Akekawatchai, Chareeporn; Sanguansermsri, Phanchana; fraser, Lan Hamilton; Pratoomsoot, Chayanin; Sanguansermsri, Donruedee

doi:10.21010/ajtcam.v15i2.2

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Phytocompounds from parts of this plant were reported with extra health benefits, including antinociceptive and antidiarrheal [ 8 ], antioxidant, antimalarial, antimicrobial [ 9 ], and antibacterial [ 10 ] activities. In addition, EO from Z. rhetsa fruits has shown a preventative ability on several breast [ 11 ] and lung [ 12 ] cancer cell lines, as well as on leukemia [ 13 ]. On the other side, M. tonkinensis (syn.…”

Section: Introductionmentioning

confidence: 99%

Anti-Diabetes, Anti-Gout, and Anti-Leukemia Properties of Essential Oils from Natural Spices Clausena indica, Zanthoxylum rhetsa, and Michelia tonkinensis

et al. 2022

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Essential oils (EOs) of Clausena indica fruits, Zanthoxylum rhetsa fruits, and Michelia tonkinensis seeds were analyzed for their phytochemical profiles and biological activities, including anti-diabetes, anti-gout, and anti-leukemia properties. Sixty-six volatile compounds were identified by gas chromatography–mass spectrometry (GC–MS), in which, myristicin (68.3%), limonene (44.2%), and linalool (49.3%) were the most prominent components of EOs extracted from C. indica, Z. rhetsa, and M. tonkinensis, respectively. In addition, only EOs from C. indica inhibited the activities of all tested enzymes comprising α-amylase (IC50 = 7.73 mg/mL), α-glucosidase (IC50 = 0.84 mg/mL), and xanthine oxidase (IC50 = 0.88 mg/mL), which are related to type 2 diabetes and gout. Remarkably, all EOs from C. indica, Z. rhetsa (IC50 = 0.73 mg/mL), and M. tonkinensis (IC50 = 1.46 mg/mL) showed a stronger anti-α-glucosidase ability than acarbose (IC50 = 2.69 mg/mL), a known anti-diabetic agent. Moreover, the growth of leukemia cell Meg-01 was significantly suppressed by all EOs, of which, the IC50 values were recorded as 0.32, 0.64, and 0.31 mg/mL for EOs from C. indica, Z. rhetsa, and M. tonkinensis, respectively. As it stands, this is the first report about the inhibitory effects of EOs from C. indica and Z. rhetsa fruits, and M. tonkinensis seeds on the human leukemia cell line Meg-01 and key enzymes linked to diabetes and gout. In conclusion, the present study suggests that EOs from these natural spices may be promising candidates for pharmaceutical industries to develop nature-based drugs to treat diabetes mellitus or gout, as well as malignant hematological diseases such as leukemia.

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Section: Introductionmentioning

confidence: 99%

Anti-Diabetes, Anti-Gout, and Anti-Leukemia Properties of Essential Oils from Natural Spices Clausena indica, Zanthoxylum rhetsa, and Michelia tonkinensis

et al. 2022

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The chemical composition and biological activities of plant essential oils against Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae)

Altaf,

Ullah,

Arshad

et al. 2024

J Plant Dis Prot

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Zanthoxylum rhetsa (Roxb.) DC Oil Suppresses the Proliferation, Activates Apoptosis, Inhibits Migration of Human Cervical Cancer Cells

Buranrat¹,

Utsintong²

2022

J. of Pharmacology and Toxicology

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Background and Objective: Zanthoxylum rhetsa (Roxb.) DC are spices for Thai food and it has been used for the treatment of several diseases. However, the activity of Z. rhetsa oil against cancer has not been fully investigated. In this study, the constituents of Z. rhetsa oil were characterized and explored the cytotoxic effects in cervical cancer cells. Materials and Methods: Zanthoxylum rhetsa oil was attained by hydro-distillation and was considered the active compound by Gas Chromatography-Mass Spectrometry (GCMS). The oil was evaluated for antioxidant, cytotoxicity, colony formation, apoptosis and migration in the human cervical cancer HeLa cell line. Results: Twenty-eight known compounds were identified in oil, including monoterpenes, sesquiterpenes and hydrocarbon. The oil inhibited the HeLa cell proliferation with a low IC 50 value and decreased colony formation. Significantly, the induction of early apoptotic cell death was induced by the oil and a higher percentage was indicated at 250 µg mLG 1 . The cell number was reduced after incubating with the oil for 24 hrs and morphological change was observed at 250 µg mLG 1 . The mechanism of cell death and apoptosis was detected in the induction of ROS formation and were significant at the dose of 100 and 250 µg mLG 1 . Finally, the oil stimulated anti-migratory activities of the cervical HeLa. Conclusion: Zanthoxylum rhetsa oil was demonstrated to induce cancer cell death, activate early apoptosis and suppress the migration ability of cervical cancer cells through stimulating ROS formation.

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CHEMICAL COMPOSITIONS AND BIOLOGICAL PROPERTIES OF ESSENTIAL OILS FROM ZANTHOXYLUM RHETSA (ROXB.) DC AND ZANTHOXYLUM LIMONELLA ALSTON. Pg

Cited by 3 publications

References 9 publications

Anti-Diabetes, Anti-Gout, and Anti-Leukemia Properties of Essential Oils from Natural Spices Clausena indica, Zanthoxylum rhetsa, and Michelia tonkinensis

Anti-Diabetes, Anti-Gout, and Anti-Leukemia Properties of Essential Oils from Natural Spices Clausena indica, Zanthoxylum rhetsa, and Michelia tonkinensis

The chemical composition and biological activities of plant essential oils against Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae)

Zanthoxylum rhetsa (Roxb.) DC Oil Suppresses the Proliferation, Activates Apoptosis, Inhibits Migration of Human Cervical Cancer Cells

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