Chemical composition of the essential oil from aerial parts of Micromeria fruticulosa (Bertol.) Grande (Lamiaceae) growing wild in Southern Italy

Rigano, Daniela; Formisano, Carmen; Senatore, F.; Bellone, Gabriella; Bruno, M.; Rosselli, Sergio

doi:10.1055/s-2006-950028

Cited by 2 publications

(4 citation statements)

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“…This compound has antioxidant and antibacterial activities [16]. Terpinolene was described to be present in essential oils of Micromeria fruticosa but in smaller amounts [17].…”

Section: Gc-ms Analysis Of the Phytochemical Compenentsmentioning

confidence: 99%

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GC–MS-Based Metabolites Profiling, In Vitro Antioxidant, Anticancer, and Antimicrobial Properties of Different Solvent Extracts from the Botanical Parts of Micromeria fruticosa (Lamiaceae)

et al. 2022

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The present study assessed the metabolites and bioactivities of Micromeria fruticosa plant parts extracted with various solvents (ethanol, n-hexane, and water) through the steeping extraction method. Thereafter, the extracts were analyzed using GC-MS. Moreover, the extracts were tested for their antioxidant, antimicrobial, and antitumor activities. The quali-quantitative analysis of Micromeria fruticosa crude extracts revealed the occurrence of 27 secondary metabolites. Some major bioactives identified were menthone, oleamide, pulegone, and menthol. Numerous antioxidant minerals, viz., Fe, Zn, and Mn, were present. The water extract of leaves exhibited the highest DPPH scavenging activity (89.73%), followed by the water extract of flowers (80.07%) at 100 μg/mL. The stems’ water extract demonstrated greater antimicrobial activity against all the bacteria species tested. The ethanolic leaf and aqueous stem extracts exhibited strong activity against C. albicans and E. coli. Flowers’ aqueous extract demonstrated the highest cytostatic effect on the colon cell line by reducing viability, followed by the leaves’ ethanol extract. The extraction solvents influenced the recovery of phytocompounds, and the highest pharmacological activities of the different extracts could be correlated to the presence of additional bioactives. Our results suggest that the Micromeria fruticosa plant is a favorable source of natural products with promising properties for potential nutraceutical and functional food applications.

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“…This compound has antioxidant and antibacterial activities [16]. Terpinolene was described to be present in essential oils of Micromeria fruticosa but in smaller amounts [17].…”

Section: Gc-ms Analysis Of the Phytochemical Compenentsmentioning

confidence: 99%

“…β-caryophyllene is a sesquiterpene compound that was barely detected in the ethanolic extract of flowers of Micromeria fruticosa (4.14%). These compounds were described previously in Micromeria fruticosa [17] but not in the solvent extracts from different botanical parts.…”

Section: Gc-ms Analysis Of the Phytochemical Compenentsmentioning

confidence: 99%

GC–MS-Based Metabolites Profiling, In Vitro Antioxidant, Anticancer, and Antimicrobial Properties of Different Solvent Extracts from the Botanical Parts of Micromeria fruticosa (Lamiaceae)

et al. 2022

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show abstract

“…This compound has an antioxidant, and antibacterial activities [15]. Terpinolene was described in essential oils of M. fruticosa but with smaller amounts [16].…”

Section: Gc-ms Analysis Of the Phytochemical Compenentsmentioning

confidence: 99%

“…β-caryophyllene is a sesquiterpene compound has merely detected in the ethanolic extract of flowers of M. fruticosa (4.14%). These compounds were described previously in Micromeria fruticosa [16] but not in the solvent extracts from different botanical parts. Another sesquiterpene (β-Cubebene), was identified in the ethanolic extract of both leaves and flowers of M. fruticosa with percentage area, 3.96 and 1.44%, respectively.…”

Section: Gc-ms Analysis Of the Phytochemical Compenentsmentioning

confidence: 99%

GC–MS Based Metabolites Profiling, In Vitro Antioxidant, Antibacterial, and Anti-Cancer Properties of Different Solvent Extracts from Leaves, Stems, Roots, and Flowers of <em>Micromeria fruticosa</em> (Lamiaceae)

Abu‐Reidah¹,

Al-Nuri²,

Afifi³

et al. 2022

Preprint

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This study assesses the secondary metabolites, minerals, antimicrobial, antioxidant, and anticancer properties of Micromeria fruticosa plant different botanical parts (leaf, stem, root, flower) extracted with various solvents. The plant samples were sequentially obtained using different solvents (n-hexane, ethanol and water) through steeping. Then, each of the extracts was further analyzed by using gas chromatography–mass spectrometry (GC-MS). Moreover, the extracts were bio-assayed to test their antioxidant, antibacterial, and anti-cancer activities. Quali-quantitative analysis of M. fruticosa crude extracts revealed the occurrence of 27 secondary metabolites were identified including mainly monoterpenes, sesquterpenes, and fatty acids, with varying quantities. Some of the major bioactive compounds included, Menthone (5.42-30.05%), Oleamide (3.40-32.20%), Pulegone (10.66-64.1%), and Menthol (3.61-100.0%), which were detected mostly in all plant parts with significant quantities. Several antioxidant minerals, mainly, Fe, Zn, and Mn, were detected with the highest amounts in the Micromeria water extracts. Results from antimicrobial assays showed that the water extract of leaves exhibited the highest DPPH scavenging activity (89.73%) followed by the water extract of flowers (80.07%) at a concentration of 100 μg/mL. The water extract of stems showed greater antimicrobial activity against all the tested gram negative and positive bacteria (Methicillin-resistant Staphylococcus aureus, Staphylococcus aureus, Escherichia coli, and Shigella sonnie). The leaves ethanolic and stem aqueous extracts had a strong antimicrobial activity against E. coli. and C. albicans. Flower aqueous extract demonstrated the highest cytostatic effect on the colon cell line by reducing viability up to 30.4%, followed by the leaf ethanol extract with 38.6% cell viability reduction at 1000 µg/mL. In conclusion, extraction solvents influenced the recovery of phytocompounds and the highest pharmacological activities of the different extracts could be correlated to the presence of additional bioactive compounds. Our results suggest that M. fruticosa plant is a promising source of natural products with antioxidant, anti-microbial and anti-cancer properties for potential nutraceutical, therapeutic, and functional food applications. , , , , , ,

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Chemical composition of the essential oil from aerial parts of Micromeria fruticulosa (Bertol.) Grande (Lamiaceae) growing wild in Southern Italy

Cited by 2 publications

References 0 publications

GC–MS-Based Metabolites Profiling, In Vitro Antioxidant, Anticancer, and Antimicrobial Properties of Different Solvent Extracts from the Botanical Parts of Micromeria fruticosa (Lamiaceae)

GC–MS-Based Metabolites Profiling, In Vitro Antioxidant, Anticancer, and Antimicrobial Properties of Different Solvent Extracts from the Botanical Parts of Micromeria fruticosa (Lamiaceae)

GC–MS Based Metabolites Profiling, In Vitro Antioxidant, Antibacterial, and Anti-Cancer Properties of Different Solvent Extracts from Leaves, Stems, Roots, and Flowers of <em>Micromeria fruticosa</em> (Lamiaceae)

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