Chemical Composition of the Essential Oil of Catha edulis Forsk from Djibouti and Its Toxicological Investigations In Vivo and In Vitro

Abdoul-Latif, Fatouma Mohamed; Ainane, Ayoub; Aboubaker, Ibrahim Houmed; Ali, Ali Merito; Montassir, Zineb El; Kciuk, Mateusz; Jalludin, Mohamed; Ainane, Tarik

doi:10.3390/pr11051324

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…Lactones or cyclic esters (like coumarin) can also form from cinnamic acid derivatives. Sometimes the aliphatic chain is reduced to a single carbon atom, as is the case with vanillin ( Figure 1 ) [ 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Potent Anticancer Activity of Essential Oils and Their Bioactive Compounds: Mechanisms and Prospects for Future Cancer Therapy

Mohamed Abdoul-Latif,

Ainane,

Houmed Aboubaker

et al. 2023

Pharmaceuticals

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Cancer is one of the leading causes of death worldwide, affecting millions of people each year. Fortunately, the last decades have been marked by considerable advances in the field of cancer therapy. Researchers have discovered many natural substances, some of which are isolated from plants that have promising anti-tumor activity. Among these, essential oils (EOs) and their constituents have been widely studied and shown potent anticancer activities, both in vitro and in vivo. However, despite the promising results, the precise mechanisms of action of EOs and their bioactive compounds are still poorly understood. Further research is needed to better understand these mechanisms, as well as their effectiveness and safety in use. Furthermore, the use of EOs as anticancer drugs is complex, as it requires absolute pharmacodynamic specificity and selectivity, as well as an appropriate formulation for effective administration. In this study, we present a synthesis of recent work on the mechanisms of anticancer action of EOs and their bioactive compounds, examining the results of various in vitro and in vivo studies. We also review future research prospects in this exciting field, as well as potential implications for the development of new cancer drugs.

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Section: Introductionmentioning

confidence: 99%

Exploring the Potent Anticancer Activity of Essential Oils and Their Bioactive Compounds: Mechanisms and Prospects for Future Cancer Therapy

Mohamed Abdoul-Latif,

Ainane,

Houmed Aboubaker

et al. 2023

Pharmaceuticals

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Levels and Health Risk Assessments of Heavy Metals in Khat and Its Support Soil in Algesachi, Ilu Ababor, Ethiopia

Damana,

Geletu,

Keru

2024

Environ�Health�Insights

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Background: Khat ( Catha edulis Forsk) is a stimulant plant grown in East Africa and the Arabian Peninsula. Heavy metal pollution has been a global concern due to its acute and chronic health effects and the major route of exposure is the consumption of contaminated foods. In this study, the determination and health risk assessment of heavy metals (Mn, Cu, Zn, Ni, Cr, Cd, and Pb) in khat and its support soil samples was carried out. Materials and Methods: Khat and its support soil were analyzed for the levels of 7 toxic heavy metals by Atomic Absorption Spectrophotometer. Samples were randomly collected from 3 districts of khat farming kebeles and digested using mixture of strong acids. Results: The concentrations (mg/kg) of analytes in soil and khat samples were: Cu (6.78-35.80); Zn (24.30-199.02); Mn (7.59-1855.40); Ni (6.37-64.80); Cr (0.82-169.20); Cd (14.2-38.8), and Pb (ND). Among the analyzed heavy metals in soil, Mn was with the highest concentration, followed by Zn, Cr, Cu, Ni, and Cd while that of Zn was the maximum followed by Cu, Mn, and Cr in khat. The levels of Zn, Cr, and Cd in soil samples from all study sites and detected concentrations of Cr in khat samples exceeded the recommended FAO/WHO levels. Conclusion: The hazard index (HI) of metals in khat from study areas was less than 1 indicating a less likelihood of non-carcinogenic toxicological health effects. However, the presence of these toxic chemicals in soil and khat indicates product contamination and needs extensive further investigation involving other heavy metals.

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Khat chewing and its associated factors among pregnant women in Chiro district, eastern Ethiopia: a community-based study

Geremew,

Kebede,

Negash

et al. 2023

Front. Psychiatry

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IntroductionDespite its deleterious consequences, khat chewing is escalating worldwide. However, there is a lack of evidence about the extent of khat chewing among pregnant women in Ethiopia, particularly in the current study area. Therefore, this study aimed to assess the prevalence of current khat chewing and its associated factors among pregnant women in Chiro district, eastern Ethiopia.MethodsThis community-based cross-sectional study was conducted in Chiro district from November 1 to 30, 2022 G.C. Study participants were selected using the systematic random sampling technique. An interview-administered structured questionnaire was used to collect data through a house-to-house survey. The data were entered into EpiData version 3.1 and analyzed in STATA 14 software. Characteristics of study participants were summarized using descriptive analysis, and binary logistic regression was used to identify determinants of khat chewing.ResultsA total of 409 pregnant women participated in this study, with a response rate of 99%. The overall prevalence of khat chewing was 60.4% (95% CI: 55.5%, 65.2%). Religion (AOR: 2.08; 95% CI: 1.13, 3.82), khat cultivation (AOR: 0.43; 95% CI: 0.25, 0.77), partner khat use (AOR: 5.54; 95% CI: 3.11, 9.88), pre-pregnancy khat use (AOR: 9.95; 95% CI: 5.55, 17.81), antenatal care (ANC) visit (AOR: 2.71; 95% CI: 1.41, 5.21), and mental distress (AOR: 4.89; 95% CI: 2.38, 10.02) were significantly associated with current khat chewing.ConclusionThe majority of pregnant women in the study area practice khat chewing. Thus, accessible and comprehensive pre-conception and pre-natal care incorporating the prevention and management of antenatal khat chewing is crucial to overcome this problem. Provision of mental healthcare involving partners of pregnant women is also important to reduce the extent and impacts of khat chewing during pregnancy. Further longitudinal studies triangulated with qualitative designs are recommended.

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Chemical Composition of the Essential Oil of Catha edulis Forsk from Djibouti and Its Toxicological Investigations In Vivo and In Vitro

Cited by 4 publications

References 38 publications

Exploring the Potent Anticancer Activity of Essential Oils and Their Bioactive Compounds: Mechanisms and Prospects for Future Cancer Therapy

Exploring the Potent Anticancer Activity of Essential Oils and Their Bioactive Compounds: Mechanisms and Prospects for Future Cancer Therapy

Levels and Health Risk Assessments of Heavy Metals in Khat and Its Support Soil in Algesachi, Ilu Ababor, Ethiopia

Khat chewing and its associated factors among pregnant women in Chiro district, eastern Ethiopia: a community-based study

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