Chemical composition of pumpkin (Cucurbita maxima) seeds and its supplemental effect on Indian women with metabolic syndrome

Monica, Sarah Jane; John, Sheila; Madhanagopal, R; Sivaraj, C; Khusro, Ameer; Arumugam, P; Gajdács, Márió; Lydia, D. Esther; Sahibzada, Muhammad Umar Khayam; Alghamdi, Saad; Almehmadi, Mazen; Emran, Talha Bin

doi:10.1016/j.arabjc.2022.103985

Cited by 12 publications

(13 citation statements)

References 48 publications

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“…PUFA present in corn and pumpkin seed oils have demonstrated antihypertensive effect in clinical trials ( 126 , 127 ). At the same time, the fatty acids from pumpkin seeds also have shown antiobesity effects in human trials ( 128 ).…”

Section: Micronutrientsmentioning

confidence: 99%

“…Authors conclude that pumpkin seeds have a high potential to be used in the human diet to manage noncommunicable diseases such as diabetes and hypercholesterolemia. In another study, Indian women (aged 30–50 years) diagnosed with metabolic syndrome received 5 g of pumpkin seeds for 60 days ( 128 ). Anthropometric measurements (body weight 72.20 kg, waist circumference 90.62 cm), biochemical parameters (HDL cholesterol 42.24 mg/dL, non-HDL cholesterol 142.05 mg/dL, LDL cholesterol 120.22 mg/dL,), and systolic blood pressure (122 mm Hg) showed statistically significant improvement ( p < 0.05) compared to control group (patients without pumpkin seed).…”

Section: Micronutrientsmentioning

confidence: 99%

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Nutritional, bioactive components and health properties of the milpa triad system seeds (corn, common bean and pumpkin)

et al. 2023

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The milpa system is a biocultural polyculture technique. Heritage of Mesoamerican civilizations that offers a wide variety of plants for food purposes. Corn, common beans, and pumpkins are the main crops in this agroecosystem, which are important for people’s nutritional and food security. Moreover, milpa system seeds have great potential for preventing and ameliorating noncommunicable diseases, such as obesity, dyslipidemia, type 2 diabetes, among others. This work reviews and analyzes the nutritional and health benefits of milpa system seeds assessed by recent preclinical and clinical trials. Milpa seeds protein quality, vitamins and minerals, and phytochemical composition are also reviewed. Evidence suggests that regular consumption of milpa seeds combination could exert complementing effect to control nutritional deficiencies. Moreover, the combination of phytochemicals and nutritional components of the milpa seed could potentialize their individual health benefits. Milpa system seeds could be considered functional foods to fight nutritional deficiencies and prevent and control noncommunicable diseases.

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Section: Micronutrientsmentioning

confidence: 99%

Section: Micronutrientsmentioning

confidence: 99%

Nutritional, bioactive components and health properties of the milpa triad system seeds (corn, common bean and pumpkin)

et al. 2023

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“…Chia and pumpkin seeds contain antioxidants and omega-3 fatty acids, which are essential to maintain normal health. 32,33 The traditional use of flax seed for the management of PCOS has been known for long. Evidence is available that suggests that the use of flax seed in PCOS has been shown to improve basal metabolic rate and insulin resistance, it has also managed hirsutism and lipid profiles.…”

Section: Significance Statementmentioning

confidence: 99%

“…Chia and pumpkin seeds contain antioxidants and omega‐3 fatty acids, which are essential to maintain normal health 32,33 . The traditional use of flax seed for the management of PCOS has been known for long.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of Linum usitatissimum seeds to inhibit estrogen receptor as a natural therapy for PCOS: An in silico and in vitro analysis

Ahmad,

Ahmed,

Shakeel

et al. 2023

Cell Biochemistry & Function

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Polycystic ovarian syndrome (PCOS) is an endocrinological disorder aroused due to hormonal disturbances. It is characterized by anovulation due to an excess of androgen and estrogen hormones, thus leading to the formation of multiple cysts, imposing life‐threatening conditions. This manuscript aimed to introduce a natural estrogen receptor (ESR) inhibitors that can provide protection against PCOS. The computational analysis of Linum usitatissimum seeds compounds against ESR alpha receptor was performed, and the binding affinities of the ligand compounds and receptor proteins were scrutinized. Nine lignin compounds were docked, and the results were compared with that of reference estrogen receptor inhibitors, clomiphene, and tamoxifen. The binding affinity scores for pinoresinol, lariciresinol, secoisolariciresinol, and matairesinol were −10.67, −10.66, −10.91, and −10.60 kcal mol−1, respectively. These were comparable to the binding affinity score of reference compounds −11.406 kcal mol−1 for clomiphene and −10.666 kcal mol−1 for tamoxifen. Prime MM‐GBSA studies showcased that Linum usitatissimum seeds compounds exhibit significant efficacy and efficiency towards receptor protein. Moreover, MD‐simulation studies were performed and the results depict that the lignin compounds form stable complexes at 300 K throughout the simulation time. For further clarity, in‐vitro experiments were carried out. The results exhibit the decline in cell proliferation in a concentration‐dependent manner by extract 1 (ethyl acetate) EX1 and extract 2 (petroleum ether) EX2. Hence, providing evidence regarding the anti‐estrogenic activity of the sample extracts. Collectively, these results showed that flax seed can reduce the levels of estrogen, which can induce ovulation and prevent cyst formation, and ultimately can provide protection against PCOS.

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“…ERK/PPAγ/γ-adiponectin; increase of SOD and GSH; decreased inflammatory cytokines and inflammatory infiltrate; increased insulin secretion; decreased peroxidation and hepatic lipid synthesis; HDL-; regulation of HMG-CoA reductase and acyl-CoA; inhibition of β-oxidation of fatty acids; HDL increase; leptin regulation; decrease in inflammatory cytokines and inflammatory infiltrate; ROS decrease (84) Saponin Anti-dyslipidemic potential Decreased cholesterol and triglycerides; SOD increase; increased bile salts; decreased expression of HMG-CoA reductase and SREBR-1c; AMPK activation; decreases; GPAT decreased; decreased triglycerides; reducing the absorption of lipids and glucose in intestine; enhance colon health; reducing the oxidative stress in β-pancreatic cells (and phenylalanine free radical scavengers; TNF-α decreased; increased lipoprotein lipase; anorexigenic effect; HMG-CoA reductase inhibition; inhibition of α-amylase and α-glucosidase (97-103) PUFA AntihypertensiveAnti-obesity Reducing systolic blood pressure, LDL levels, arterial stiffness; decreasing body weight and waist circumference;increases HDL levels(127)(128)(129) ERK/PPAγ, phosphorilation of extracellular signal-regulated kinase activated by peroxisome proliferator-activated receptors; SOD: superoxide dismutase; GSH, hormone L-g-glutamil-Lcisteinil-glicine; HDL, high-density lipoprotein; ROS, reactive oxygen species; HMG-CoA, β-hydroxy β-methylglutaryl-coenzyme A; SREBP: sterol regulatory element-binding proteins; AMPK, AMP-activated protein kinase; PPAR: peroxisome proliferator-activated receptors; GPAT, glycerol phosphate acyltransferase; TNF-α: tumor necrosis factor alpha.…”

mentioning

confidence: 99%

Diversified Agri-food Production Systems for Nutritional Security

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Chemical composition of pumpkin (Cucurbita maxima) seeds and its supplemental effect on Indian women with metabolic syndrome

Cited by 12 publications

References 48 publications

Nutritional, bioactive components and health properties of the milpa triad system seeds (corn, common bean and pumpkin)

Nutritional, bioactive components and health properties of the milpa triad system seeds (corn, common bean and pumpkin)

The efficacy of Linum usitatissimum seeds to inhibit estrogen receptor as a natural therapy for PCOS: An in silico and in vitro analysis

Diversified Agri-food Production Systems for Nutritional Security

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