Chemical composition of Nigella sativa Linn: Part 2 Recent advances

Khan, Maria; Afzal, Muhammad

doi:10.1007/s10787-016-0262-7

Cited by 73 publications

(35 citation statements)

References 101 publications

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“… 2004a , 2004b ; Ali & Blunden 2003 ; Ahmad et al. 2013 ; Akram Khan & Afzal 2016 ). Different pharmacological effects have been identified for NS, such as immune stimulation (Salem 2005 ), anti-inflammatory properties (Chehl et al.…”

Section: Introductionmentioning

confidence: 99%

Methanol extract of Nigella sativa seed induces changes in the levels of neurotransmitter amino acids in male rat brain regions

El-Naggar

Carretero

Arce

et al. 2017

Pharmaceutical Biology

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Context:Nigella sativa L. (Ranunculaceae) (NS) has been used for medicinal and culinary purposes. Different parts of the plant are used to treat many disorders.Objective: This study investigates the effects of NS methanol extract on brain neurotransmitter amino acid levels.Materials and methods: We measured the changes in aspartate, glutamate, glycine and γ-aminobutyric acid in five brain regions of male Wistar rats after methanol extract treatment. Animals were injected intraperitoneally with saline solution (controls) or NS methanol extract (equivalent of 2.5 g/kg body weight) and sacrificed 1 h later or after administering 1 daily dose for 8 days. The neurotransmitters were measured in the hypothalamus, cortex, striatum, hippocampus and thalamus by HPLC.Results and discussion: Results showed significant changes in amino acids compared to basal values. Glutamate increased significantly (16–36%) in the regions analyzed except the striatum. Aspartate in the hypothalamus (50 and 76%) and glycine in hippocampus (32 and 25%), thalamus (66 and 29%) and striatum (75 and 48%) also increased with the two treatment intervals. γ-Aminobutyric acid significantly increased in the hippocampus (38 and 32%) and thalamus (22 and 40%) but decreased in the cortex and hypothalamus although in striatum only after eight days of treatment (24%).Conclusion: Our results suggest that injected methanol extract modifies amino acid levels in the rat brain regions. These results could be of interest since some neurodegenerative diseases are related to amino acid level imbalances in the central nervous system, suggesting the prospect for therapeutic use of NS against these disorders.

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Section: Introductionmentioning

confidence: 99%

Methanol extract of Nigella sativa seed induces changes in the levels of neurotransmitter amino acids in male rat brain regions

El-Naggar

Carretero

Arce

et al. 2017

Pharmaceutical Biology

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“…Chemically, NS contains 30% fixed oils (mainly fatty acids), 0.40–0.45% volatile oils, vitamins, amino acids, proteins, carbohydrates, alkaloids, saponins, crude fiber, and minerals. NS oil (NSO) is rich in polyunsaturated fatty acids (PUFA), phytosterols, TQ (up to 25% in volatile oil), carvacrol, t-anethole, sesquiterpenelongifolene, and 4 terpinol (Liu et al, 2011 ; Akram Khan and Afzal, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease

Cascella

Bimonte

Barbieri

et al. 2018

Front. Aging Neurosci.

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Several nutraceuticals have been investigated for preventing or retarding the progression of different neurodegenerative diseases, including Alzheimer's disease (AD). Because Nigella sativa (NS) and its isolated compound thymoquinone (TQ) have significant anti-oxidant and anti-inflammatory proprieties, they could represent effective neuroprotective agents. The purpose of this manuscript is to analyze and to recapitulate the results of in vitro and in vivo studies on the potential role of NS/TQ in AD's prevention and treatment. The level of evidence for each included animal study has been assessed by using a modified CAMARADES (Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies) 10-item checklist. We used MEDLINE and EMBASE databases to screen relevant articles published up to July 2017. A manual search was also performed. The database search yielded 38 studies, of which 18 were included in this manuscript. Results from these approaches suggest that NS or TQ could represent an effective strategy against AD due to the balancing of oxidative processes and the binding to specific intracellular targets. The overall effects mainly regard the prevention of hippocampal pyramidal cell loss and the increased cognitive functions.

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“…The seeds of this plant contain oil, protein, alkaloids such as ni–glycine and ni–glydine, and quinones such as thymoquinone, saponin, and volatile essence. [ 15 ] The pharmacologic and biologic effects of N. sativa and thymoquinone, as the components of N. sativa , include antioxidant, anti-ischemic, anti-inflammation, analgesic, antiepileptic, and anticough effects. [ 16 ] Studies carried out on N. sativa have indicated that it has antibacterial, anticonvulsant, and antioxidant properties, reduces blood glucose, and collects the free radicals.…”

Section: Introductionmentioning

confidence: 99%

Effect of Thymoquinone on Reproductive Parameter in Morphine-treated Male Mice

et al. 2018

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Background:Thymoquinone as the main active component of Nigella sativa might have a various pharmacological effects such as antiapoptotic and antioxidant. Morphine is commonly used for the treatment of severe pain that can increase the generation of free radicals and affects the spermatogenesis. This study was designed to evaluate protective effects of thymoquinone against morphine-induced damages, sperm viability, count, motility, morphology and testis histology, and nitric oxide and testosterone hormone of the mice.Materials and Methods:In this experimental study, we divided 48 mice into eight groups (n = 6); various doses of thymoquinone (2, 10, and 20 mg/kg) and morphine (20 mg/kg) plus thymoquinone (2, 10, and 20 mg/kg) were administered intraperitoneally to 48 male mice for 30 consequent days. Male reproductive parameters including testis weight, testosterone hormone, serum nitric oxide, germinal thickness, sperm morphology, count, viability, and motility were analyzed and compared.Results:The results indicated that morphine administration significantly decreased germinal thickness, testis weight, testosterone level, viability, morphology, count, and motility of sperm and increased nitric oxide as compared to saline group (P < 0.05). However, increasing the dose of thymoquinone in the thymoquinone and thymoquinone plus morphine groups significantly decreases nitric oxide level (P < 0.05) while significantly boosted motility, morphology, count, viability of sperm cells, germinal thickness, and testosterone hormone in all groups as compared to morphine group (P < 0.05).Conclusion:It seems that thymoquinone administration could increase the quality some of spermatozoa and improves morphine-induced adverse effects on reproductive parameters in male mice

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Chemical composition of Nigella sativa Linn: Part 2 Recent advances

Cited by 73 publications

References 101 publications

Methanol extract of Nigella sativa seed induces changes in the levels of neurotransmitter amino acids in male rat brain regions

Methanol extract of Nigella sativa seed induces changes in the levels of neurotransmitter amino acids in male rat brain regions

Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease

Effect of Thymoquinone on Reproductive Parameter in Morphine-treated Male Mice

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