Chemical Composition of<i>Teucrium alopecurus</i>Essential Oil from Tunisia

Hachicha, Souleima F.; Skanji, T.; Barrek, Sami; Zarrouk, H.; Ghrabi, Zeineb

doi:10.1080/10412905.2007.9699939

Cited by 13 publications

(9 citation statements)

References 10 publications

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“…α-Humulene was relatively abundant in all three T. yemense samples (4.0%–6.4%), while α-cadinol was relatively abundant (2.0 and 9.5%) in the two T. yemense samples in this current investigation. Sesquiterpenoids, including ( E )-caryophyllene, α-humulene, germacrene D, δ-cadinene, caryophyllene oxide, α-cadinol, and τ-cadinol, have been generally abundant in Teucrium essential oils ( Table 2 ) [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. Although relatively abundant in T. yemense , 7- epi -α-selinene has been found in relatively small amounts in T. persicum [ 46 ] and T. capitatum [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial, Antioxidant, and Cytotoxic Activities of Ocimum forskolei and Teucrium yemense (Lamiaceae) Essential Oils

et al. 2017

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Background: Ocimum forskolei and Teucrium yemense (Lamiaceae) are used in traditional medicine in Yemen. Methods: The chemical composition, antimicrobial, antioxidant and cytotoxic activities of the essential oils isolated from the leaves of Ocimum forskolei Benth. (EOOF) and two different populations of Teucrium yemense Deflers., one collected from Dhamar province (EOTY-d), and another collected from Taiz (EOTY-t) were investigated. The antimicrobial activities of the oils were evaluated against several microorganisms with the disc diffusion test or the broth microdilution test. The essential oils were screened for in-vitro cytotoxic activity against human tumor cells. EOOF and EOTY-d were screened for free-radical-inhibitory activity using the DPPH radical scavenging assay. Results: Sixty-four compounds were identified in (EOOF) representing 100% of the oil content with endo-fenchol (31.1%), fenchone (12.2%), τ-cadinol (12.2%), and methyl (E)-cinnamate (5.1%) as the major compounds. In EOTY-d, 67 compounds were identified, which made up 91% of the total oil. The most abundant constituents were (E)-caryophyllene (11.2%), α-humulene (4.0.%), γ-selinene (5.5%), 7-epi-α-selinene (20.1%), and caryophyllene oxide (20.1%), while the major compounds in EOTY-t were α-pinene (6.6%), (E)-caryophyllene (19.1%) α-humulene (6.4%), δ-cadinene (6.5%), caryophyllene oxide (4.3%), α-cadinol (9.5%), and shyobunol (4.6%). The most sensitive microorganisms for EOOF were B. subtilis, S. aureus, and C. albicans with inhibition zones of 34, 16, and 24 mm and MIC values of, 4.3 mg/mL, 4.3 mg/mL, and 8.6 mg/mL, respectively. EOTY-t showed antimicrobial activity against S. aureus, B. cereus, A. niger, and B. cinerea with MIC values of 0.156, 0.156, 0.313 and 0.313 mg/mL, respectively. Neither essential oil showed remarkable radical inhibition (IC50 = 31.55 and 31.41 μL/mL). EOTY-d was active against HT-29 human colorectal adenocarcinoma cell lines with IC50 = 43.7 μg/mL. Consistent with this, EOTY-t was active against both MCF-7 and MDA-MB-231 human breast adenocarcinoma cells. Conclusions: The antimicrobial activity of Ocimum forskolei essential oil against B. subtilis and C. albicans is consistent with its traditional use in Yemeni traditional medicine to treat skin infections. Both O. forskolei and T. yemense show wide variations in their respective essential oil compositions; there remains a need to investigate both species botanically, genetically, and phytochemically more comprehensively.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial, Antioxidant, and Cytotoxic Activities of Ocimum forskolei and Teucrium yemense (Lamiaceae) Essential Oils

et al. 2017

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“…In particular, δ-cadinene and germacrene D are the main compounds in the oils of different Teucrium species such as T. flavum and T. chamaedrys from Iran [9,12], T scorodonia L. ssp. scorodonia from Italy [20], T. algarbiensis from Portugal [10], T. alopecurus from Tunisia [21] and T. montanum from Turkey [8].…”

Section: Teucrium Maghrebinum Greuter Et Burdet Is a Newmentioning

confidence: 99%

Analysis of Essential Oil from Teucrium maghrebinum Greuter et Burdet Growing Wild in Algeria

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Senatore

et al. 2009

Natural Product Communications

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The chemical composition of the essential oil obtained from aerial parts of Teucrium maghrebinum growing wild in Algeria was analyzed by GC and GC-MS. Among the 66 identified compounds, δ-cadinene (12.7%), germacrene D (11.4%), γ-cadinene (9.5%) and 4-vinyl guaiacol (4.0%) were the most abundant. The oil is strongly characterized by the presence of sesquiterpenes (61.5%), particularly hydrocarbon sesquiterpenes (49.6%).

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“…Previous reports on the chemical composition of Teucrium alopecurus essential oil growing in Tunisia showed sesquiterpenes, mainly δ-cadinene (13.4%), α-humulene (12.3%), and nerolidyl acetate (12.3%), as its major components [ 30 ]. There is also data in the literature about the most abundant fatty acids, where Linolenic, linoleic, and palmitic acids together made up 74.2% of Teucrium alopecurus collected from Matmata, Gabes (Tunisia), and the highest number of sterols were stigmasterol, sitosterol, phytosterol, and clerosterol [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Terpenes from essential oils and hydrolate ofTeucrium alopecurustriggered apoptotic events dependent on caspases activation and PARP cleavage in human colon cancer cells through decreased protein expressions

et al. 2018

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This study focused on characterizing the Hydrophobic and Hydrophilic fractions of Teucrium alopecurus in the context of cancer prevention and therapy. The goal was also to elucidate the molecular mechanisms involved and to determine its efficacy against cancer by triggering apoptosis and suppressing tumorigenesis in human colon cancer. The data here clearly demonstrated that oily fractions of Teucrium alopecurus act as free radical scavengers, antibacterial agent and inhibited the proliferation of HCT-116, U266, SCC4, Panc28, KBM5, and MCF-7 cells in a time- and concentration-dependent manner. The results of live/dead and colony formation assays further revealed that Teucrium essential oil has the efficacy to suppress the growth of colon carcinoma cells. In addition, essential oil of Teucrium alopecurus induced apoptosis, as indicated by cleavage of caspases-3, -8, and -9 and poly-adenosine diphosphate ribose polymerase. Moreover, Teucrium alopecurus essential oil suppressed gene expression involved in survival, proliferation, invasion, angiogenesis, and metastasis in human colon cancer cells. No sign of toxicity was detected in vivo after treatment with increasing concentrations of essential oil. Oral administration of T.alopecurus inhibited LPS-induced colon inflammation. This anticancer property of this specie Teucrium alopecurus fractions could be due to their phenolic and/or sesquiterpene content (d-limonene, α-Bisabolol, Humulene, Thymol, and (+)-epi-Bicyclosesquiphellandrene). Hence our study reveals the anticancer activity of Teucrium alopecurus oil mediated through the suppression of cell growth, cell proliferation, and the induction of apoptosis of cancer cells. Thus, it has potential to be developed as an anticancer agent; however more in vitro and in vivo studies are warranted.

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Chemical Composition ofTeucrium alopecurusEssential Oil from Tunisia

Cited by 13 publications

References 10 publications

Antimicrobial, Antioxidant, and Cytotoxic Activities of Ocimum forskolei and Teucrium yemense (Lamiaceae) Essential Oils

Antimicrobial, Antioxidant, and Cytotoxic Activities of Ocimum forskolei and Teucrium yemense (Lamiaceae) Essential Oils

Analysis of Essential Oil from Teucrium maghrebinum Greuter et Burdet Growing Wild in Algeria

Terpenes from essential oils and hydrolate ofTeucrium alopecurustriggered apoptotic events dependent on caspases activation and PARP cleavage in human colon cancer cells through decreased protein expressions

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