Chemical composition of Erycibe schmidtii and antiproliferative activity of scopoletin on immature dendritic cells

Abstract

Immature dendritic cells (iDCs) play very important roles in the pathological process of rheumatoid arthritis (RA). Therefore, it is urgent to search for natural products with antiproliferative activity on iDCs for anti-RA drug discovery. Erycibe schmidtii, a traditional Chinese medicine, has been used to treat RA in China. Its bioactive ingredients on RA are still unclear. In this study, twenty compounds including a new caffeoylquinic acid derivative, 3-O-caffeoyl-4-O-syringoylquinic acid methyl ester (16), were isolated from E. schmidtii. Their structures were elucidated by NMR and mass spectroscopic analyses, and comparison with literature data. Seventeen compounds were obtained from this plant for the first time, and ten were first found from the genus Erycibe. Scopoletin (1, 5.0 μM) functionally reduced proliferation level of bone marrow immature dendritic cells (BM-iDCs) more than 50%, relative to vehicle. However, scopoletin (1) exhibited no effect on the phagocytosis or survival of BM-iDCs in vitro.

A Network Pharmacology‐Based Study on the Anti‐Lung Cancer Effect of Dipsaci Radix

“…Moreover, caffeoylquinic acid derivatives, also known as strong antioxidant compounds, can effectively treat human leukemia and lung adenocarcinoma by inducing dysfunction of mitochondria [21]. Caffeoylquinic acid derivative also significantly decreased the proliferation level of bone marrow immature dendritic cells, whose function is often disrupted by cancer cells [22,23].…”

“…erefore, DR targeting bone may retard tumor growth and promote anticancer immunity. Sitosterol can ameliorate the state of bone fragility and fracture possibly due to estrogenic modulation [22]. In addition, several studies have indicated that sitosterol inhibit the proliferation of different cultured cancer cell lines such as prostate cancer, ovarian cancer, breast cancer, colon cancer, stomach cancer, leukemia, and lung cancer.…”

Chemical compositions, pharmacological activities, quality control studies of Erycibes plants, and the development of their substitutes

“…Fifteen coumarins [compounds 1–6 (Liu et al, 2007), 8 (Feng, Liu, Yang, et al, 2016), 14–15 (Liu et al, 2013), 16 (Liu et al, 2007), 17 (Fan et al, 2015), and 18–21 (Fan et al, 2013; Feng, Liu, Xu, et al, 2016)] have been isolated from E. obtusifolia , while nine coumarins [compounds 1 , 2 , and 7–13 (Song et al, 2010)] have been isolated from E. hainanesis . From E. schmidtii and E. elliptilimba , only two coumarins, scopoletin and scopolin, have been isolated (Lu et al, 1986; Ren et al, 2019; Song et al, 1997). Three bis‐coumarins [compounds 5–6 (Liu et al, 2007) and 7 (Song et al, 2010)] have been isolated from E. obtusifolia and E. hainanesis , among which 7,7′‐dihydroxy‐6,6′‐dimethoxy‐3,3′‐biscoumarin (compound 5 ) and 7,7′‐dihydroxy‐6,6′‐dimethoxy‐8,8′‐biscoumarin (compound 6 ) are relatively rare bis‐coumarins with fully symmetric carbon–carbon bonds.…”

“…Currently, 43 quinic acid derivatives have been isolated and identified from Erycibes plants. Among them, 10 quinic acid derivatives [compounds 22 , 25–27 , 33 , and 35–39 (Song et al, 2010)] have been found in E. hainanesis , 32 quinic acid derivatives [compounds 23–24 (Chen, Tao, et al, 2014), 30–32 (Fan et al, 2013), 36 (Fan et al, 2015; Liu et al, 2014), 38–57 (Fan et al, 2013, 2015; Liu et al, 2014), 59–62 (Liu et al, 2014), and 63–64 (Feng, Liu, Yang, et al, 2016)] have been found in E. obtusifolia , and 14 quinic acid derivatives [compounds 22–23 , 25 (Song et al, 1997; Zhou et al, 2016), 28–32 (Ren et al, 2019; Zhou et al, 2016), 34 , 41–43 , 48 , and 58 (Ren et al, 2019)] have been obtained from E. schmidtii . Compounds 22–29 are monocaffeoyl quinic acid and their methyl, ethyl or butyl derivatives; compounds 30–35 and 49–51 are dicaffeoyl quinic acids and their methyl, ethyl or butyl ester derivatives; and compounds 36–48 and 52–64 are bisacylquinic acid derivatives that present different acyl group substitutes of caffeoyl, syringoyl, sinapoyl, and vanilloyl.…”

“…Among all 15 lignans, seven lignans [compounds 104 , 106 (Feng, Liu, Yang, et al, 2016), and 109–113 (Liu et al, 2013)] have been isolated from E. obtusifolia . Five [compounds 103 (Feng et al, 2014) and 105–108 (Song et al, 2010)] have been isolated from E. hainanesis , and four [compounds 99–102 (Ren et al, 2019)] have been isolated from E. schmidtii . Compound 106 is a common lignan existing in both E. obtusifolia and E. hainanesis .…”