Chemical composition of Gastrocotyle hispida (Forssk.) bunge and Heliotropium crispum Desf. and evaluation of their multiple in vitro biological potentials

Shahbaz, Amir; Abbasi, Banzeer Ahsan; Iqbal, Javed; Fatima, Iram; Zahra, Syeda Anber; Kanwal, Sobia; Devkota, Hari Prasad; Capasso, Raffaele; Ahmad, Ajaz; Mahmood, Tariq

doi:10.1016/j.sjbs.2021.09.040

Cited by 20 publications

(9 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The main mechanism used for phytofabrication of NPs is due to the presence of phytochemicals (Iqbal, Abbasi, Ahmad, Batool, et al, 2018; Iqbal, Abbasi, Khalil, et al, 2018; Iqbal, Abbasi, Ahmad, Batool, et al, 2019; Iqbal, Abbasi, Mahmood, Hameed, et al, 2019; Iqbal, Abbasi, Mahmood, et al, 2019; Shahbaz et al, 2021; Ali, Khan, Batool, Shah, et al, 2021; Ali, Khan, Iqbal, Shah, et al, 2021). The major phytochemical responsible for the reduction, stabilization and capping of NPs are carboxylic acids, aldehydes, ketones, amides, quinones, flavonoids, terpenoids, polysaccharides, and proteins (Iqbal, Abbasi, Ahmad, Mahmood, Kanwal, et al, 2018; Iqbal, Abbasi, Ahmad, Mahmood, Ali, et al, 2018; Abbasi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Rhamnella gilgitica functionalized green synthesis of ZnONPs and their multiple therapeutic properties

Abbasi

Iqbal

Israr

et al. 2022

Microscopy Res & Technique

Self Cite

View full text Add to dashboard Cite

In the recent years, green synthesis of zinc oxide nanoparticles (ZnONPs) using plant extracts and phytochemicals has gained significant attention. In present research study, facile, green, and tunable ZnONPs were biosynthesized from Rhamnella gilgitica leaf aqueous extract as a strong reducing and stabilizing agents. The prepared ZnONPs@Rhamnella were characterized and validated using common nanotechnology techniques (UV-Vis, XRD, EDX, FT-IR, SEM, TEM, DLS, and Raman) and revealed spherical morphology with particle size ~21 nm. The asynthesized ZnONPs were further evaluated for different biological applications. Strong antimicrobial efficacies were reported for ZnONPs using discdiffusion method and were capable of rendering significant antimicrobial potential.ZnONPs were evaluated against HepG2 (IC 50 : 18.40 μg/ml) and HUH7 (IC 50 : 20.59 μg/ml) cancer cell lines and revealed strong anticancer properties. Dose-dependent MTT cytotoxicity assay was confirmed using Leishmania tropica "KWH23 strain" (promastigote: IC 50 : 26.78 μg/ml and amastigote: IC 50 : 29.57 μg/ml). Antioxidant activities (DPPH: 93.36%, TAC: 72.43%) were performed to evaluate their antioxidant potentials. Further, protein kinase and α-amylase inhibition assays were determined. Biocompatibility assays were done using human RBCs and macrophages thus revealed biosafe and non-toxic nature of ZnONPs@Rhamnella. In current experiment, we concluded that greenly orchestrated ZnONPs is an attractive, non-toxic and ecofriendly candidate and showed potential biological activities. In future, different clinical trials and in vivo studies are necessary for the confirmation of these remedial properties of ZnONPs using different animal models. Research highlights1. Greenly orchestrated ZnONPs were synthesized using Rhamnella gilgitica leaves broth.2. Analytical techniques such as UV, SEM, TEM, XRD, FTIR, DLS, and Raman confirmed synthesis of ZnONPs.3. Green ZnONPs determined strong antimicrobial, cytotoxic, and antioxidant potentials. 4. Significant enzyme inhibition and biocompatibility assays were investigated.

show abstract

Section: Introductionmentioning

confidence: 99%

Rhamnella gilgitica functionalized green synthesis of ZnONPs and their multiple therapeutic properties

Abbasi

Iqbal

Israr

et al. 2022

Microscopy Res & Technique

Self Cite

View full text Add to dashboard Cite

show abstract

“… 246 , 247 , 248 Ethno‐medico‐botanicals have been used across almost all the cultures worldwide against an array of human medical conditions. 50 , 51 , 52 , 53 The use of betel leaf alone and with a combination of other plants or medicines for better therapeutic effects is mentioned in the Ayurvedic literature, which was almost 1400 BC ago. 54 Atharved, the ancient Vedic literature, mentioned the usefulness of the betel plant against numerous diseases at about 3000–2500 BC before.…”

Section: Traditional and Ethno‐medicinal Usementioning

confidence: 99%

“…Traditional medicine has played a crucial role in the health care of the rural and urban people 246‐248 . Ethno‐medico‐botanicals have been used across almost all the cultures worldwide against an array of human medical conditions 50‐53 . The use of betel leaf alone and with a combination of other plants or medicines for better therapeutic effects is mentioned in the Ayurvedic literature, which was almost 1400 BC ago.…”

Section: Traditional and Ethno‐medicinal Usementioning

confidence: 99%

Betelvine (Piper betleL.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Biswas

Anand

Saha

et al. 2022

J Cellular Molecular Medi

View full text Add to dashboard Cite

Piper betle L. (synonym: Piper betel Blanco), or betel vine, an economically and medicinally important cash crop, belongs to the family Piperaceae, often known as the green gold. The plant can be found all over the world and is cultivatedprimarily in South East Asian countries for its beautiful glossy heart‐shaped leaves, which are chewed or consumed as betelquidand widely used in Chinese and Indian folk medicine, as carminative, stimulant,astringent, against parasitic worms, conjunctivitis, rheumatism, wound, etc., andis also used for religious purposes. Hydroxychavicol is the most important bioactive compound among the wide range of phytoconstituents found in essential oil and extracts. The pharmacological attributes of P . betle are antiproliferation, anticancer, neuropharmacological, analgesic, antioxidant, antiulcerogenic, hepatoprotective, antifertility, antibacterial, antifungal and many more. Immense attention has been paid to nanoformulations and their applications. The application of P . betle did not show cytotoxicity in preclinical experiments, suggesting that it could serve as a promising therapeutic candidate for different diseases. The present review comprehensively summarizes the botanical description, geographical distribution, economic value and cultivation, ethnobotanical uses, preclinical pharmacological properties with insights of toxicological, clinical efficacy, and safety of P . betle . The findings suggest that P . betle represents an orally active and safe natural agent that exhibits great therapeutic potential for managing various human medical conditions. However, further research is needed to elucidate its underlying molecular mechanisms of action, clinical aspects, structure–activity relationships, bioavailability and synergistic interactions with other drugs.

show abstract

“…According to the World Health Organization, 80% of world depends on the traditional use of plants to cure diseases and this dependency is increasing day by day because of cost-effectiveness, safety, and high quality as compared to synthetic marketed drugs [ 13 ]. Research studies have revealed that different medicinal plants and their constituents possess antiproliferative [ 9 ], antimicrobial [ 14 ], antioxidant, antihemolytic [ 15 ], anticancer [ 11 , 16 ], antidepressant [ 17 , 18 ], antioxidant, anti-inflammatory, analgesic, antinociceptive [ 19 ], antiarthritic, aphrodisiac, analgesic [ 12 , 20 ], and other pharmacological properties.…”

Section: Introductionmentioning

confidence: 99%

Preclinical Rodent Models of Arthritis and Acute Inflammation Indicate Immunomodulatory and Anti-Inflammatory Properties of Juglans regia Extracts

Mobashar

Shabbir

Shahzad

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Juglans regia has been used to treat inflammatory and arthritic disorders in traditional medicine. The present study aimed to investigate the antiarthritic and anti-inflammatory potential of ethanolic leaves extract of J. regia. Arthritis was induced in rodents with Freund’s complete adjuvant. J. regia treatment was started on 8th day of arthritis induction and sustained for 20 days. Acute inflammatory models were developed using carrageenan, histamine, serotonin, and dextran. Qualitative and GC-MS analyses were also performed. Arthritis was determined using an arthritis scoring index and histopathological examination of ankle joints. RT-PCR was performed to determine the expression of pro-inflammatory markers (TNF-α, NF-κB, IL-6, IL-1β, and COX-2) and anti-inflammatory IL-4. PGE2 levels were evaluated using an ELISA. Blood and biochemical parameters were also determined. Paw edema was measured using a digital plethysmometer. Treatment with extracts inhibited arthritic development and attenuated paw edema along with all histopathological parameters. The expression levels of pro-inflammatory cytokines and COX-2 were downregulated, while IL-4 was upregulated. PGE2 levels were also reduced in extract-treated groups. Blood and biochemical parameters were nearly normalized in the treatment groups. Both extracts significantly inhibited carrageenan, histamine, serotonin, and dextran-induced paw edema. Qualitative phytochemical screening and GC-MS analysis confirmed that extracts possessed potential medicinal compounds. In conclusion, ethanol and n-hexane extracts of J. regia leaves have immunomodulatory and anti-inflammatory effects that ameliorate experimentally induced arthritis and edema. The inhibition of autacoids may also be one of the mechanisms inducing the immunomodulatory effect.

show abstract

Chemical composition of Gastrocotyle hispida (Forssk.) bunge and Heliotropium crispum Desf. and evaluation of their multiple in vitro biological potentials

Cited by 20 publications

References 60 publications

Rhamnella gilgitica functionalized green synthesis of ZnONPs and their multiple therapeutic properties

Rhamnella gilgitica functionalized green synthesis of ZnONPs and their multiple therapeutic properties

Betelvine (Piper betleL.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Preclinical Rodent Models of Arthritis and Acute Inflammation Indicate Immunomodulatory and Anti-Inflammatory Properties of Juglans regia Extracts

Contact Info

Product

Resources

About