Chemical Composition of Fennel Oil, <i>Foeniculum vulgare</i> Miller, from Spain

García-Jiménez, Noemí; Pérez‐Alonso, María José; Velasco‐Negueruela, Arturo

doi:10.1080/10412905.2000.9699487

Cited by 47 publications

(28 citation statements)

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“…Based on the high estragole ratios recorded (0.93-0.98), it is expected that the cultivated population of bitter fennel belongs to the previously described estragole-rich chemotype (Muckenstrum et al 1997;Barazani et al 2002;Gross et al 2009). Natural fennel populations with similar estragole-dominant profiles, ranging between 35 and 89 %, have already been identified in Spain (Garcia-Jimenez et al 2000), Israel (Barazani et al 2002) and Italy (Piccaglia and Marotti 2001;Napoli et al 2010).…”

Section: Discussionmentioning

confidence: 94%

Larvicidal, molluscicidal and nematicidal activities of essential oils and compounds from Foeniculum vulgare

et al. 2014

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Plant-based products, namely essential oils (EOs), are environmentally friendly alternatives for the control of disease vectors, hosts and/or parasites. Here, we studied the general toxicity and biopesticidal potential of EOs and phenylpropanoids from Foeniculum vulgare var. vulgare (bitter fennel), a perennial plant well adapted to temperate climates. EO/compound toxicity was tested against a freshwater snail and potential intermediate host of Fasciola hepatica (Radix peregra), a mosquito and former European malaria vector (Anopheles atroparvus) and one of the most damaging plant-parasitic nematodes, the root-knot nematode (Meloidogyne javanica). Lethal concentrations (LC 50 ; LC 90 ) of EOs (infrutescences/stems with leaves) and compounds were calculated by probit analysis. All displayed noteworthy activity against R. peregra adults (LC 50 21-39 lg ml -1 ) and A. atroparvus larvae (LC 50 16-56 lg ml -1 ). trans-Anethole revealed acute nematicidal activity after 24 and 48 h (LC 50 310 and 249 lg ml -1 , respectively), and estragole (1,000 lg ml -1 ) showed some effectiveness against M. javanica hatching and juveniles after 15 days. Plant and EO yields were determined to evaluate the bitter fennel productivity. The chemical composition of the EOs was analyzed by gas chromatography coupled to mass spectrometry. EOs extracted from whole plants, infrutescences and stems with leaves were characterized by estragoledominant profiles (28-65 %), considerable amounts of phellandrene (10-34 %) and fenchone (6-16 %), and minor trans-anethole contents (1-4 %). Although additional toxicological studies against nontarget organisms are required, our study demonstrates that bitter fennel is a productive source of molluscicides and larvicides, and thus a potential sustainable biological agent to control particular host species, namely freshwater snails and mosquitoes.

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Section: Discussionmentioning

confidence: 94%

Larvicidal, molluscicidal and nematicidal activities of essential oils and compounds from Foeniculum vulgare

et al. 2014

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“…Regarding phenylpropanoids, estragole and trans-anethole have been reported as constituents of the F. vulgare essential oil (EFSA, 2012(EFSA, , 2009García-Jiménez et al, 2000). The genotoxic and carcinogenic (mainly hepatocarcinogenic) effects of estragole are well established in several rodent models.…”

Section: Monoterpenes Phenylpropanoids and Prenylflavonoidsmentioning

confidence: 99%

Wild edible plants: Nutritional and toxicological characteristics, retrieval strategies and importance for today's society

Pinela

Ferreira

2017

Food and Chemical Toxicology

137

111

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A B S T R A C TWild edible plants (WEPs) are part of the cultural and genetic heritage of different regions of the world. In times of famine and scarcity, these sources of nutrients and health-promoting compounds have received high importance mainly in rural and suburban areas. Although currently underutilized, WEPs are still consumed traditionally by different communities and are gaining relevance in today's society. However, these foods lack recognition as significant contributors to the human diet in developed areas. This review describes the nutritional value of WEPs from the North-eastern region of Portugal and points out those containing potentially toxic compounds. Several retrieval strategies are presented with the aim of promoting the (re)use, production, commercialization and conservation of WEPs (wild harvested plants and crop wild relatives), and their importance for social, economic and agro-ecological development is highlighted.

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“…The essential oil of fennel is used as additive in the food, pharmaceutical, cosmetic, and perfume industries (Tinoco et al, 2007), besides having important medicinal properties, such as diuretic, anti-inflammatory, analgesic, antioxidant (Gross et al, 2002), antiseptic, sedative, carminative, stimulant, and vermifugal activities (He and Huang, 2011;Tinoco et al, 2007). In the literature, (E)-anethole and the monoterpenes limonene and fenchone are often reported as the main constituents of this essential oil of fennel (Akgul and Bayrak, 1988;Anwar et al, 2009;Cosge et al, 2008;Garcia-Jimenez et al, 2000).…”

Section: Introductionmentioning

confidence: 98%

Cytotoxicity screening of essential oils in cancer cell lines

Oliveira

Alves

Damasceno

et al. 2015

Revista Brasileira de Farmacognosia

135

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a b s t r a c tThis study evaluated the cytotoxicity activity of the essential oils of Tagetes erecta L., Asteraceae (TE-OE), Tetradenia riparia (Hochst.) Codd, Lamiaceae (TR-OE), Bidens sulphurea (Cav.) Sch. Bip., Asteraceae (BS-OE), and Foeniculum vulgare Mill., Apiaceae (FV-OE), traditionally used in folk medicine, against the tumor cell lines murine melanoma (B16F10), human colon carcinoma (HT29), human breast adenocarcinoma (MCF-7), human cervical adenocarcinoma (HeLa), human hepatocellular liver carcinoma (HepG2), and human glioblastoma (MO59J, U343, and U251). Normal hamster lung fibroblasts (V79 cells) were included as control. The cells were treated with essential oil concentrations ranging from 3.12 to 400 g/ml for 24 h. The cytotoxic activity was evaluated using the XTT assay; results were expressed as IC 50 , and the selectivity index was calculated. The results were compared with those achieved for classic chemotherapeutic agents. TE-OE was the most promising among the evaluated oils: it afforded the lowest IC 50 values for B16F10 cells (7.47 ± 1.08 g/ml) and HT29 cells (6.93 ± 0.77 g/ml), as well as selectivity indices of 2.61 and 2.81, respectively. The major BS-EO, FV-EO and TE-EO chemical constituents were identified by gas chromatography mass spectrometry as being (E)-caryophyllene (10.5%), germacrene D (35.0%) and 2,6-di-tert-butyl-4-methylphenol (43.0%) (BS-EO); limonene (21.3%) and (E)-anethole (70.2%) (FV-EO); limonene (10.4%), dihydrotagetone (11.8%), ␣-terpinolene (18.1%) and (E)-ocimenone (13.0%) (TE-EO); and fenchone (6.1%), dronabinol (11.0%), aromadendrene oxide (14.7%) and (E,E)-farnesol (15.0%) (TR-EO). 2,6-di-tert-butyl-4-methylphenol (43.0%), (E)-anethole (70.2%) and ␣-terpinolene (18.1%), respectively. These results suggest that TE-OE may be used to treat cancer without affecting normal cells.

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Chemical Composition of Fennel Oil, Foeniculum vulgare Miller, from Spain

Cited by 47 publications

References 4 publications

Larvicidal, molluscicidal and nematicidal activities of essential oils and compounds from Foeniculum vulgare

Larvicidal, molluscicidal and nematicidal activities of essential oils and compounds from Foeniculum vulgare

Wild edible plants: Nutritional and toxicological characteristics, retrieval strategies and importance for today's society

Cytotoxicity screening of essential oils in cancer cell lines

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