Chemical Composition of Essential Oilsof Thymus and Mentha Speciesand Their Antifungal Activities

Sokóvić, Marina; Vukojević, Jelena; Marin, Petar D.; Brkić, Dejan; Vajs, Vlatka; Griensven, L. J. L. D. van

doi:10.3390/molecules14010238

Cited by 344 publications

(240 citation statements)

References 20 publications

(37 reference statements)

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“…The main constituents in the leaf essential oil of Curcuma longa, identified are Terpinolene (more than 26 %), 1,8-Cineole, α-Phellandren, Terpinen-4-ol and Sabinyl acetate are present only as trace constituents. Sokovic et al (2009) (Kaul et al, 1976;Lahariya and Rao, 1979) but have not described the nature of the toxic action (fungistatic/fungicidal). To the best of our knowledge, this the first report where the waste leaves of Curcuma longa L. which has no commercial value has been used for the extraction of essential oil and their antidermatophytic use, thereby making it economical.…”

Section: Discussionmentioning

confidence: 99%

Studies on antidermatophytic activity of waste leaves of Curcuma longa L.

Pandey

Mishra

Kamran

et al. 2010

Physiol Mol Biol Plants

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During antidermatophytic screening of some essential oils, Curcuma longa L. exhibited the strongest antifungal activity, completely inhibiting the mycelial growth of ringworm, caused by the fungi-Microsporum gypseum and Trichophyton mentagrophytes. The essential oil from leaves of Curcuma longa was fungicidal at 2.5 l/ml at which it tolerated heavy doses of inoculum. The fungicidal activity of the oil was thermostable up to 80 ºC and self life up to 24 months in storage. The oil also showed a broad fungitoxic spectrum, inhibiting the mycelial growth of other fungi, viz., Epidermophyton floccosum, M. nanum, T. rubrum, T. violaceum. Moreover, up to 5 % concentration it did not exhibit any adverse effect on mammalian skins. The oil has been formulated in the form of an ointment, 1 % w/v and subjected to topical testing on patients of the Out Patient Department (OPD) at Moti Lal Nehru Medical College, Allahabad. Patients were selected on the basis of KOHpositive results and diagnosed tenia corporis. After the second week of treatment, all patients were KOH-negative. At the end of medication, 75 % of patients recovered completely while 15 % showed significant improvement from the disease. The ointment thus, can be exploited commercially after ongoing successful clinical trials. Relationship of the dermatophytes to the toxicity of the oil vis-a-vis phylogeny using molecular data of the pathogens have also been discussed.

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Section: Discussionmentioning

confidence: 99%

Studies on antidermatophytic activity of waste leaves of Curcuma longa L.

Pandey

Mishra

Kamran

et al. 2010

Physiol Mol Biol Plants

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“…Lots of work has been done on the chemical composition of Thyme oil [20,22,[29][30]. Thymol is major constituents of oil ranging from 42.6-57.8% according to collection time and cultivation place.…”

Section: T Vulgaris An Important Spice Is Widely Used In Various Ailmentioning

confidence: 99%

Screening of Thymus Vulgaris Essential Oil Against Fungi Causing Dermatophytosis in Human Beings

Jain

Sharma

2017

Int J Pharm Pharm Sci

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Objective: The study was designed to determined antidermatophytic activity of Thymus vulgaris essential oil against fungi causing superficial skin infections in human and animal.Methods: Minimum inhibitory concentration (MIC) of essential oil was screened against selected pathogenic fungi namely Trichophyton rubrum (MTCC 296), T. mentagrophytes (MTCC 7687), Microsporum gypseum (MTCC 4524), M. fulvum(MTCC2837), T. soudanense and T. interdigitale through semi solid agar antifungal susceptibility testing method(SAAS). Minimum fungicidal concentration (MFC) was also determined by modified semi solid agar antifungal susceptibility method. T. soudanense and T. interdigitalis were isolated through TO. KA. VA hair bating technique from animal habitats soil of Jaipur district. Results:T. vulgaris essential oil exhibited excellent antideramtophytic activity against all selected dermatophytes. Minimum inhibitory concentration was ranged from 0.020±0.000μl/ml to 0.1±0.033 μl/ml. MFC were found little higher than MIC (0.02±0.000μl/ml to.2±0.000μl/ml). M. gypseum was found to be most susceptible fungus as compared to other test fungi. Conclusion:T. vulgaris was found to be most effective fungicidal agent against human pathogenic fungi. Present findings provide for a rationale basis of a possible utilization of this oil in fields requiring safe and cheap compounds with antiseptic and preservative properties, such as cosmetic, pharmaceutical and food industries.

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“…It is known that Gram positive bacterial species are more susceptible to antimicrobial agents than Gram negative bacteria, and that fungi are more susceptible than bacteria in general. 42,43 Thus, the susceptibility of microorganisms to external agents depends not only on their properties, but also on the microorganism itself. …”

Section: Antifungal Activitymentioning

confidence: 99%

Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives

Petrova

Potewar

Correia‐da‐Silva

et al. 2015

Carbohydrate Research

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A B S T R A C TA library of 1-(1′,2,3,3′,4,4′,6-hepta-O-acetyl-6′-deoxy-sucros-6′-yl)-1,2,3-triazoles have been investigated for their antibacterial, antifungal and cytotoxic activities. Most of the target compounds showed good inhibitory activity against a variety of clinically and food contaminant important microbial pathogens. In particular, 1-(1′,2,3,3′,4,4′,6-hepta-O-acetyl-6′-deoxy-sucros-6′-yl)-4-(4-pentylphenyl)-1,2,3-triazole (5) was highly active against all the tested bacteria with minimal inhibitory concentrations (MICs) ranging between 1.1 and 4.4 μM and bactericidal concentrations (MBCs) from 2.2 and 8.4 μM. The compound 1-(1′,2,3,3′,4,4′,6-hepta-O-acetyl-6′-deoxy-sucros-6′-yl)-4-(4-bromophenyl)-1,2,3-triazole (3) showed antifungal activity with MICs from 0.6 to 4.8 μM and minimal fungicidal concentrations (MFCs) ranging between 1.2 and 8.9 μM. Furthermore, some of the compounds possessed moderate cytotoxicity against human breast, lung, cervical and hepatocellular carcinoma cell lines, without showing toxicity for nontumor liver cells. The above mentioned derivatives represent promising leads for the development of new generation of sugar-triazole antifungal agents.

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Chemical Composition of Essential Oilsof Thymus and Mentha Speciesand Their Antifungal Activities

Cited by 344 publications

References 20 publications

Studies on antidermatophytic activity of waste leaves of Curcuma longa L.

Studies on antidermatophytic activity of waste leaves of Curcuma longa L.

Screening of Thymus Vulgaris Essential Oil Against Fungi Causing Dermatophytosis in Human Beings

Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives

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