Chemical composition, lipid peroxidation, and fatty acid profile in meat of broilers fed with glycerol monolaurate additive

Valentini, Juliana; Silva, A.S. Da; Fortuoso, Bruno F.; Reis, João H.; Gebert, Roger R.; Griss, Luiz Gustavo; Boiago, Marcel M.; Lopes, Leonardo Quintana Soares; Santos, Roberto C.V.; Wagner, Róger; Tavernari, F. de C.

doi:10.1016/j.foodchem.2020.127187

Cited by 39 publications

(26 citation statements)

References 28 publications

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“…In the current study, reduced MDA content and increased T-SOD and T-AOC activity in the sera and jejuna indicated that GML reduced lipid peroxidation and improved the antioxidant capacity of the broilers. This result is in a line with a previous study ( 12 ). In laying hens, increase in SOD level and reduced glutathione and MDA levels were observed, suggesting that GML can decrease lipid peroxidation and enhance the antioxidant capacities of broilers.…”

Section: Discussionsupporting

confidence: 94%

“…Despite the potential of GML as an additive in broiler feed to change meat quality ( 11 ) and fatty acid profile ( 12 ), the information on the influence of GML on the immune and antioxidant response of broilers is insufficient. In an oral cell/bacteria co-culture dual-chamber model, GML modulated the host immune response and metabolite production, which demonstrated that GML could be considered a potential candidate for in vivo studies ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

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Glycerol Monolaurate Ameliorated Intestinal Barrier and Immunity in Broilers by Regulating Intestinal Inflammation, Antioxidant Balance, and Intestinal Microbiota

et al. 2021

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This study was conducted to investigate the impact of glycerol monolaurate (GML) on performance, immunity, intestinal barrier, and cecal microbiota in broiler chicks. A total of 360 one-day-old broilers (Arbor Acres) with an average weight of 45.7 g were randomly allocated to five dietary groups as follows: basal diet and basal diets complemented with 300, 600, 900, or 1200 mg/kg GML. Samples were collected at 7 and 14 days of age. Results revealed that feed intake increased (P < 0.05) after 900 and 1200 mg/kg GML were administered during the entire 14-day experiment period. Dietary GML decreased (P < 0.05) crypt depth and increased the villus height-to-crypt depth ratio of the jejunum. In the serum and jejunum, supplementation with more than 600 mg/kg GML reduced (P < 0.05) interleukin-1β, tumor necrosis factor-α, and malondialdehyde levels and increased (P < 0.05) the levels of immunoglobulin G, jejunal mucin 2, total antioxidant capacity, and total superoxide dismutase. GML down-regulate (P < 0.05) jejunal interleukin-1β and interferon-γ expression and increased (P < 0.05) the mRNA level of zonula occludens 1 and occludin. A reduced (P < 0.05) expression of toll-like receptor 4 and nuclear factor kappa-B was shown in GML-treated groups. In addition, GML modulated the composition of the cecal microbiota of the broilers, improved (P < 0.05) microbial diversity, and increased (P < 0.05) the abundance of butyrate-producing bacteria. Spearman’s correlation analysis revealed that the genera Barnesiella, Coprobacter, Lachnospiraceae, Faecalibacterium, Bacteroides, Odoriacter, and Parabacteroides were related to inflammation and intestinal integrity. In conclusion, GML ameliorated intestinal morphology and barrier function in broiler chicks probably by regulating intestinal immune and antioxidant balance, as well as intestinal microbiota.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Glycerol Monolaurate Ameliorated Intestinal Barrier and Immunity in Broilers by Regulating Intestinal Inflammation, Antioxidant Balance, and Intestinal Microbiota

et al. 2021

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show abstract

“…In the current study, reduced MDA content and increased T-SOD and T-AOC activity in the sera and jejuna indicated that GML reduced lipid peroxidation and improved the antioxidant capacity of the broilers. This result is in a line with a previous study (33). In laying hens, increase in SOD level and reduced glutathione and MDA levels were observed, suggesting that GML can decrease lipid peroxidation and enhance the antioxidant capacities of broilers.…”

Section: Discussionsupporting

confidence: 94%

Glycerol monolaurate ameliorated intestinal barrier and immunity in broilers by regulating intestinal inflammation, antioxidant balance, and intestinal microbiota

Kong¹,

Wang

Xiao

et al. 2021

Preprint

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Extensive interactions occur between a poultry host and its gut microbiome. Glycerol monolaurate (GML) possesses a large range of antimicrobial and immunoregulatory properties. This study was conducted to investigate the impact of different doses of GML (basal diets complemented with 0, 300, 600, 900, or 1200 mg/kg GML) on growth performance, intestinal barrier, and cecal microbiota in broiler chicks. Results revealed that feed intake increased after 900 and 1200 mg/kg GML were administered during the entire 14-day experiment period. Dietary GML decreased crypt depth and increased the villus height-to-crypt depth ratio of the jejunum. In the serum and jejunum, supplementation with more than 600 mg/kg GML reduced interleukin-1β, tumor necrosis factor-α, and malondialdehyde levels and increased the levels of immunoglobulin G, jejunal mucin 2, total antioxidant capacity, and total superoxide dismutase. GML down-regulated jejunal interleukin-1β and interferon-γ expression and increased the mRNA level of zonula occludens 1 and occludin. A reduced expression of toll-like receptor 4 and a tendency of down-regulated nuclear factor kappa-B was shown in GML-treated groups. In addition, GML modulated the composition of the cecal microbiota of the broilers, improved microbial diversity, and increased the abundance of butyrate-producing bacteria. Spearman's correlation analysis revealed that the genera Barnesiella, Coprobacter, Lachnospiraceae, Faecalibacterium, Bacteroides, Odoriacter, and Parabacteroides were related to inflammation and intestinal integrity. In conclusion, GML ameliorated intestinal morphology and barrier function in broiler chicks probably by regulating intestinal immune and antioxidant balance, as well as intestinal microbiota.

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“…Under standard esterification conditions, monoglycerides tend to prefer the 1-monoglyceride form rather than the 2-monoglyceride form. Medium-chain monoglyceride have shown promising effects on feed efficiency, health improvement, growth performance capacity and immune status of broilers ( Fortuoso et al., 2019 ; Valentini et al., 2020 ; Amer et al., 2021 ). Monoglycerides are natural compounds which, alongside their nutritional values of lipids, act against gram-positive and gram-negative bacteria at concentrations at which no evidence for harm to the body has been found ( Mansour and Millière, 2001 ; Thormar et al., 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Buffered formic acid and a monoglyceride blend coordinately alleviate subclinical necrotic enteritis impact in broiler chickens

Gharib-Naseri

Kheravii²,

Li³

et al. 2021

Poultry Science

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The objective of this study was to evaluate the effect of 2 different doses of a partially buffered formic acid product (Amasil NA; 61% formic acid, 20.5% sodium formate), and a monoglyceride blend of short- and medium-chain fatty acids (BalanGut LS P) on necrotic enteritis ( NE ) infected broilers in terms of performance, intestinal microbial population and short-chain fatty acids concentrations in the gastrointestinal tract. A total of 528-day-old as hatched Ross 308 broilers were allocated to 48 pens with 11 birds in each pen. Six dietary treatments applied in the study were: T1) nonsupplemented diet (Control); T2) antibiotic supplemented diets; T3) and T4) high (Starter: 0.5%; Grower and Finisher: 0.5%) and low (Starter: 0.3%; Grower and Finisher: 0.2%) dose of Amasil NA; and groups T5) and T6) high (Starter: 0.3%; Grower and Finisher: 0.2%) and low dose (Starter: 0.3%; Grower: 0.15%; Finisher: 0.075%) of (BalanGut LS P). All birds in this study were fed starter (d 0-10), grower (d 11–24) and finisher (d 25–35) diets and challenged with NE. To induce subclinical NE, oral administrations of Eimeria oocysts (d 9) followed by inoculation of Clostridium perfringens strains (d 14 and 15) were applied. Results showed that birds fed the high dose of Amasil NA, had a higher feed conversion ratio ( FCR, P < 0.05) compared to the nonsupplemented group during the starter period. Antibiotic supplementation reduced FCR during the grower ( P < 0.001), finisher ( P < 0.05) and overall ( P < 0.001) periods of the experiment. Both levels of BalanGut LS P and low levels of Amasil NA enhanced overall FCR ( P < 0.05) compared to the birds in the nonsupplemented group. Compared to the nonsupplemented group, high levels of Amasil NA and low levels of BalanGut LS P improved FCR in the finisher stage ( P < 0.05). On d 16, cecum digesta of birds fed with antibiotic supplemented diets showed a significantly lower number of C. perfringens ( P < 0.001) compared to the nonsupplemented and high level of BalanGut LS P group. Bacillus ( P < 0.01) and Ruminococcus numbers were significantly lower in the birds fed with high level of Amasil NA ( P < 0.05) compared to the antibiotic supplemented diets. High doses of Amasil NA, showed the highest propionate concentration in the cecum ( P < 0.001). The study suggests that supplementation of BalanGut LS P and Amasil NA at different feeding phases may achieve optimal performance improvement in broilers under NE challenge.

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Chemical composition, lipid peroxidation, and fatty acid profile in meat of broilers fed with glycerol monolaurate additive

Cited by 39 publications

References 28 publications

Glycerol Monolaurate Ameliorated Intestinal Barrier and Immunity in Broilers by Regulating Intestinal Inflammation, Antioxidant Balance, and Intestinal Microbiota

Glycerol Monolaurate Ameliorated Intestinal Barrier and Immunity in Broilers by Regulating Intestinal Inflammation, Antioxidant Balance, and Intestinal Microbiota

Glycerol monolaurate ameliorated intestinal barrier and immunity in broilers by regulating intestinal inflammation, antioxidant balance, and intestinal microbiota

Buffered formic acid and a monoglyceride blend coordinately alleviate subclinical necrotic enteritis impact in broiler chickens

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