“…Thus, in case of environmental pollution by heavy metals it is proved that the manifestations of toxic action may depend on the interaction between them, which leads to change of thresholds, and therefore not only the toxicity of each component of the system but also their combined action is important (Slobodian et al, 2019). The results of many experimental studies indicate that Cadmium and Lead have a toxic effect on a number of organs and systems in mammals (Marushko et al, 2010;Petrynych et al, 2017;Ostapyuk & Gutyj, 2018;2019). Lead and Cadmium, when introduced into the body of animals, easily connect to thiol groups of apoproteins, and thus change the activity of antioxidant, microsomal and other enzymatic systems, affect the exchange of macro-and microelements, exhibit carcinogenic action (Al-Azemi et al, 2010;Stepanchuk, 2014;Lavryshyn et al, 2018;2019;.…”