Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line

Žižić, Jovana B.; Vuković, Nenad; Jadranin, Milka; Anđelković, Boban; Tešević, Vele; Kačániová, Miroslava; Sukdolak, Slobodan; Marković, Snežana D.

doi:10.1002/jsfa.6132

Cited by 36 publications

(29 citation statements)

References 31 publications

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“…Naringenin is also a typical chemical constituent of poplar-type propolis (24). The levels of naringenin were higher when compared with the results found in Finland (20), and similar to those determined in Serbia (25). However, the quercetin levels were lower than the reported maximum concentration in Argentina (10), were higher than the levels found in Italy, Macedonia, Ukraine, Argentina and China (16).…”

Section: Min-max Meansupporting

confidence: 71%

“…The apigenin levels were higher when compared with the levels reported in Finland (20), Croatia, Bosnia and Herzegovina and Macedonia (5), and in Italy, Macedonia, Ukraine, Argentina and China (16). The results were similar to those measured in Serbia (25), whereas the results extremely low than maximum level in Argentina (10). Naringenin is also a typical chemical constituent of poplar-type propolis (24).…”

Section: Min-max Meansupporting

confidence: 67%

“…Although kaempferol was widely detected, its mean levels were generally lower than those of other phenolic compounds in the present study. The mean levels of kaempferol were lower than those determined in Serbia (25) and Argentina (10), and were slightly higher found in Croatia (5). The mean levels of luteolin were higher than those reported in Turkey (12), and lower than the level determined in Serbia (25).…”

Section: Min-max Meancontrasting

confidence: 56%

“…However, the quercetin levels were lower than the reported maximum concentration in Argentina (10), were higher than the levels found in Italy, Macedonia, Ukraine, Argentina and China (16). The quercetin levels were similar to the levels observed in Serbia (25). Although kaempferol was widely detected, its mean levels were generally lower than those of other phenolic compounds in the present study.…”

Section: Min-max Meancontrasting

confidence: 51%

“…The mean levels of galangin were higher than the detected levels in Italy, Macedonia, Ukraine, Argentina and China (16) and also in Argentina (10). The galangin results were lower than those determined in Serbia (25) and Croatia (5), and were similar found in Macedonia (5). Pinocembrin is typical chemical constituent of poplar-type propolis (24).…”

Section: Min-max Meanmentioning

confidence: 47%

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Effects of season and altitude on biological active certain phenolic compounds levels and partial standardization of propolis

SORUCU¹

2017

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary: Propolis has antibacterial, antiviral, antifungal, anti-inflammatory, antitumoral, antioxidant, immunomodulatory, tissue regeneration, anti-ulcer, analgesic, local anaesthetic, and antiseptic effects related to its chemical components. The aim of the present study was to determine certain biological active phenolic compounds and their levels in propolis collected from Bursa province, and to evaluate propolis quality and effects of altitude and season. Propolis samples were collected using propolis traps from 15 different constant apiaries at varying altitudes (between 50 and 1000 m) located in Bursa province Turkey, during the spring, summer and autumn of 2012. Fourteen flavonoid and phenolic acids in ethanolic extracts were investigated by liquid chromatography tandem-mass spectrometry (LC-MS/MS). Galangin, naringenin, pinocembrin, caffeic acid and caffeic acid phenylethyl ester were detected in all samples (45 samples) for all seasons and altitudes. Significant differences were determined for certain phenolic compounds levels across altitudes and seasons. In the present study results showed that qualitative and quantitative analysis of propolis for useful phenolic compounds may provide partial standardization of propolis depend on altitude and season.

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Section: Min-max Meansupporting

confidence: 71%

Section: Min-max Meansupporting

confidence: 67%

Section: Min-max Meancontrasting

confidence: 56%

Section: Min-max Meancontrasting

confidence: 51%

Section: Min-max Meanmentioning

confidence: 47%

See 3 more Smart Citations

Effects of season and altitude on biological active certain phenolic compounds levels and partial standardization of propolis

SORUCU¹

2017

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Different propolis samples, phenolic content, and breast cancer cell lines: Variable cytotoxicity ranging from ineffective to potent

et al. 2018

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Researchers have started focusing on investigating the anticarcinogenic effects of natural products with the slightest side effects possible, because current breast cancer treatment approaches are unable to achieve absolute success especially on aggressive subtypes. Propolis is among these products with its antimicrobial, antifungal, anti‐inflammatory, and anticancer effects. Therefore, seven different samples were collected from different regions (Argentina, China, and Istanbul‐Turkey) and applied on nonaggressive breast cancer cell line (BCCL) MCF‐7 and aggressive cell lines SK‐BR‐3, and MDA‐MB‐231. Initially, the phenolic/flavonoid constituents of the propolis ethanol extracts were investigated by liquid chromatography‐mass spectrometry–mass spectrometry (LS‐MS/MS) and high‐performance liquid chromatography (HPLC) analyses. Then, the anticarcinogenic effects of the propolis samples on MCF‐7, SK‐BR‐3, MDA‐MB‐231 were evaluated by WST1 analysis and only selected ones on MCF‐10A and hPdLF. According to the LS‐MS/MS and HPLC analysis, Turkey originated propolis (Turkey3) were found to be richer than the other propolis samples in terms of phenolic/flavonoid compounds. Turkey propolis significantly inhibited cell proliferation in both nonaggressive and aggressive BCCL (P < 0.01). Therefore, Turkey3 propolis was selected for further evaluation using Annexin V‐PI apoptosis detection assays. In addition, selected compounds among the propolis contents such as galangin, caffeic acid, apigenin, quercetin, and ferulic acid were applied to the MCF‐7 cell line to detect cytotoxic and apoptotic effects. Galangin, caffeic acid, apigenin, and quercetin remarkably induced cell proliferation inhibition at all time intervals, whereas ferulic acid was found non efficient on the MCF‐7 cell line. Annexin V‐PI assay clarified that all cell proliferation inhibitions were markedly apoptotic. Our findings indicated that the inhibition effect of propolis on breast cancer cell proliferation was in a propolis type‐, dose‐ and time‐dependent fashion. Turkey3 propolis showed statistically significant cytotoxic effects on both the nonaggressive and aggressive BCCL. These findings were consistent with the effects of its rich phenolic and flavonoid contents, in terms of variety. © 2018 IUBMB Life, 71(5):619–631, 2019

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Biological and therapeutic properties of bee pollen: a review

2016

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Natural products, including bee products, are particularly appreciated by consumers and are used for therapeutic purposes as alternative drugs. However, it is not known whether treatments with bee products are safe and how to minimise the health risks of such products. Among others, bee pollen is a natural honeybee product promoted as a valuable source of nourishing substances and energy. The health-enhancing value of bee pollen is expected due to the wide range of secondary plant metabolites (tocopherol, niacin, thiamine, biotin and folic acid, polyphenols, carotenoid pigments, phytosterols), besides enzymes and co-enzymes, contained in bee pollen. The promising reports on the antioxidant, anti-inflammatory, anticariogenic antibacterial, antifungicidal, hepatoprotective, anti-atherosclerotic, immune enhancing potential require long-term and large cohort clinical studies. The main difficulty in the application of bee pollen in modern phytomedicine is related to the wide species-specific variation in its composition. Therefore, the variations may differently contribute to bee-pollen properties and biological activity and thus in therapeutic effects. In principle, we can unequivocally recommend bee pollen as a valuable dietary supplement. Although the bee-pollen components have potential bioactive and therapeutic properties, extensive research is required before bee pollen can be used in therapy. © 2016 Society of Chemical Industry.

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Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line

Abstract: All tested propolis samples had pronounced cytotoxic and antioxidative activities.

Cited by 36 publications

References 31 publications

Effects of season and altitude on biological active certain phenolic compounds levels and partial standardization of propolis

Effects of season and altitude on biological active certain phenolic compounds levels and partial standardization of propolis

Different propolis samples, phenolic content, and breast cancer cell lines: Variable cytotoxicity ranging from ineffective to potent

Biological and therapeutic properties of bee pollen: a review

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