Chemical Composition, Antioxidant, Antimicrobial and Cholinesterase Inhibitory Activities of Essential Oils from the Leaves and Rhizomes of<i>Acorus macrospadiceus</i>(Yamamoto) F. N.Wei et Y. K. Li

Ma, Castello; Zhu, Gangjie; Li, Tingting; Zhao, Tianming

doi:10.1080/0972060x.2022.2025911

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…Inappropriate use of antibiotics in human and animal healthcare leads to the development of bacterial resistance to available antibiotics [ 10 , 11 , 12 ]. This is a serious global problem that results in financial and human losses.…”

Section: Introductionmentioning

confidence: 99%

Effects of Silybum marianum L. Seed Extracts on Multi Drug Resistant (MDR) Bacteria

El-Sapagh,

Allam,

El-Sayed

et al. 2023

Molecules

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Wound infections became a great challenge, especially after the emergence of bacterial resistance to commonly used antibiotics. Medicinal plants can be the source of alternative antibacterial agents effective against multi drug resistant (MDR) bacteria. This research aimed to evaluate the effectiveness of different Silybum marianum seed extracts in fighting MDR bacteria that infect wounds. First, thirty purified bacterial cultures obtained from superficial, infected wounds were subjected to antibiotic sensitivity tests. The selected MDR isolates were then used to test the antimicrobial effects of different S. marianum seed extracts. The most potent extract was evaluated for its impact on the ultrastructure of the cells of sensitive bacterial isolates using transmission electron microscopy (TEM). The bioactive ingredients of this extract were analyzed by means of gas chromatography–mass spectroscopy (GC–MS). Then, in-silico absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties were predicted for the main components. The results indicated that four out of 30 bacterial isolates were considered MDR bacteria. Primary morphological features of colonies, secondary (automatic) identification using the Biomerieux Vitek 2 System, and 16S rRNA sequencing of the four isolates confirmed that they represent Staphylococcus aureus, Stenotrophomonas maltophilia, Klebsiella pneumoniae, and Escherichia coli. Among different extracts of S. marianum seeds, ethanol extract showed the strongest inhibitory effect on both Gram-positive and Gram-negative bacteria, with minimum inhibitory concentration (MIC) values between 9.375 and 1.172 mg/mL. However, at concentrations four times higher, this extract was unable to kill bacterial cells, indicating that it had a bacteriostatic effect on the tested MDR strains. TEM revealed denaturation and distorted cell ultrastructure in S. aureus and S. maltophilia after exposure to ethanol extract. In addition, GC–MS analysis of the ethanol extract identified nine compounds known to have important biological activities, and ADMET analysis showed good drug-likeness for two of these compounds. Consequently, S. marianum seeds could be a good source of alternative bacteriostatic agents effective against MDR bacterial strains that cause wound infections.

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Section: Introductionmentioning

confidence: 99%

Effects of Silybum marianum L. Seed Extracts on Multi Drug Resistant (MDR) Bacteria

El-Sapagh,

Allam,

El-Sayed

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

“…Antimicrobial resistance is one of the major challenges for the scientific community dealing either with medical science, in general, or with specific clinical trials with human and/or animal models. The elevated use/misuse of anti-toxins or antibiotic doses in human and veterinary clinical practices is mainly contributing to the occurrence of antimicrobial resistance [ 1 ]. Quick recognition in clinical research centers is imperative for the careful discovery of antimicrobial resistance.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Role of Plant Extracts and Essential Oils against Multidrug Resistance and Gram-Negative Bacterial Strains Producing Extended-Spectrum β-Lactamases

et al. 2022

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Plants, being the significant and natural source of medication for humankind against several ailments with characteristic substances hidden on them, have been recognized for many centuries. Accessibility of various methodologies for the revelation of therapeutically characteristic items has opened new avenues to redefine plants as the best reservoirs of new structural types. The role of plant metabolites to hinder the development and movement of pathogenic microbes is cherished. Production of extended-spectrum β-lactamases is an amazing tolerance mechanism that hinders the antibacterial treatment of infections caused by Gram-negative bacteria and is a serious problem for the current antimicrobial compounds. The exploration of the invention from sources of plant metabolites gives sustenance against the concern of the development of resistant pathogens. Essential oils are volatile, natural, complex compounds described by a solid odor and are framed by aromatic plants as secondary metabolites. The bioactive properties of essential oils are commonly controlled by the characteristic compounds present in them. They have been commonly utilized for bactericidal, virucidal, fungicidal, antiparasitic, insecticidal, medicinal, and antioxidant applications. Alkaloids are plant secondary metabolites that have appeared to have strong pharmacological properties. The impact of alkaloids from Callistemon citrinus and Vernonia adoensis leaves on bacterial development and efflux pump activity was assessed on Pseudomonas aeruginosa. Plant-derived chemicals may have direct antibacterial activity and/or indirect antibacterial activity as antibiotic resistance modifying agents, increasing the efficiency of antibiotics when used in combination. The thorough screening of plant-derived bioactive chemicals as resistance-modifying agents, including those that can act synergistically with antibiotics, is a viable method to overcome bacterial resistance. The synergistic assessment studies with the plant extract/essential oil and the antibiotic compounds is essential with a target for achieving a redesigned model with sustainable effects which are appreciably noticeable in specific sites of the plants compared to the entirety of their individual parts.

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Integrated Valorization of Acorus Macrospadiceus by Comprehensive Evaluation of Hydro-Distilled Essential Oil and Residual Non-Volatile Extracts

Sun,

Wang,

et al. 2024

Waste Biomass Valor

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Chemical Composition, Antioxidant, Antimicrobial and Cholinesterase Inhibitory Activities of Essential Oils from the Leaves and Rhizomes ofAcorus macrospadiceus(Yamamoto) F. N.Wei et Y. K. Li

Cited by 5 publications

References 27 publications

Effects of Silybum marianum L. Seed Extracts on Multi Drug Resistant (MDR) Bacteria

Effects of Silybum marianum L. Seed Extracts on Multi Drug Resistant (MDR) Bacteria

Synergistic Role of Plant Extracts and Essential Oils against Multidrug Resistance and Gram-Negative Bacterial Strains Producing Extended-Spectrum β-Lactamases

Integrated Valorization of Acorus Macrospadiceus by Comprehensive Evaluation of Hydro-Distilled Essential Oil and Residual Non-Volatile Extracts

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