Chemical composition, antioxidant, antimicrobial and anti-inflammatory activity of Prunus spinosa L. fruit ethanol extract

Sabatini, Luigia; Fraternale, Daniele; Giacomo, Barbara Di; Mari, Michele; Albertini, Maria Cristina; Gordillo, Belén; Rocchi, Marco; Sisti, Davide; Coppari, Sofia; Semprucci, Federica; Guidi, Loretta; Colomba, Mariastella

doi:10.1016/j.jff.2020.103885

Cited by 53 publications

(53 citation statements)

References 31 publications

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“…We evaluated the expression of markers directly related to the inflammation and wound-healing processes such as IL-6, miR-146a, IRAK-1, miR-126, and VCAM-1. MicroRNA-126 is also responsible for regulating cell adhesion molecule VCAM-1 during inflammation [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is a perennial deciduous plant growing as a shrub in wild, uncultivated areas of Europe, temperate regions of Asia, and Mediterranean countries. In particular, chemical composition, antioxidant and anti-inflammatory properties of P. spinosa fruit ethanol extract have been recently reported [ 6 ]. The most representative molecules in the extract are phenolic compounds such as anthocyanins, which represent the most abundant antioxidants in the diet.…”

Section: Introductionmentioning

confidence: 99%

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Prunus spinosa Extract Loaded in Biomimetic Nanoparticles Evokes In Vitro Anti-Inflammatory and Wound Healing Activities

et al. 2020

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Prunus spinosa fruits (PSF) contain different phenolic compounds showing antioxidant and anti-inflammatory activities. Innovative drug delivery systems such as biomimetic nanoparticles could improve the activity of PSF extract by promoting (i) the protection of payload into the lipidic bilayer, (ii) increased accumulation to the diseased tissue due to specific targeting properties, (iii) improved biocompatibility, (iv) low toxicity and increased bioavailability. Using membrane proteins extracted from human monocyte cell line THP-1 cells and a mixture of phospholipids, we formulated two types of PSF-extract-loaded biomimetic vesicles differing from each other for the presence of either 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) or 1,2-dioleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (DOPG). The biological activity of free extract (PSF), compared to both types of extract-loaded vesicles (PSF-DOPCs and PSF-DOPGs) and empty vesicles (DOPCs and DOPGs), was evaluated in vitro on HUVEC cells. PSF-DOPCs showed preferential incorporation of the extract. When enriched into the nanovesicles, the extract showed a significantly increased anti-inflammatory activity, and a pronounced wound-healing effect (with PSF-DOPCs more efficient than PSF-DOPGs) compared to free PSF. This innovative drug delivery system, combining nutraceutical active ingredients into a biomimetic formulation, represents a possible adjuvant therapy for the treatment of wound healing. This nanoplatform could be useful for the encapsulation/enrichment of other nutraceutical products with short stability and low bioavailability.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prunus spinosa Extract Loaded in Biomimetic Nanoparticles Evokes In Vitro Anti-Inflammatory and Wound Healing Activities

et al. 2020

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“…For example, phytochemicals from leaves of Naregamia alata can diminish the incidence of several chronic diseases owning to their antioxidant potential and cytotoxic activity (Madhu, Sreeja, & Priya, 2020); while antioxidants from Prunus spinosa L . fruit exhibited antimicrobial and anti‐inflammatory activity (Sabatini et al., 2020). However, many plant‐derived compounds are instable and present low bioavailability, which would challenge their application in functional foods or treatments of diseases.…”

Section: Introductionmentioning

confidence: 99%

Bioavailability and antioxidant activity of nanotechnology‐based botanic antioxidants

Myint

Xia

et al. 2021

Journal of Food Science

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Botanic bioactive substances have issues with their solubility, stability, and oral bioavailability in the application, which could be improved by nanotechnologies. In another hands, green synthesis of nanoparticles (NPs) with plant extract is also a promising technology for preparation of NPs due to its safety advantage, yet the bioactive botanic substances that could be more than the assistant of the green synthesis of NPs. Based on the above concerns, this review summarized the preparation of botanic NPs with various plant extract, their solubility, stability, and oral bioavailability; specific attention has been paid to the botanic Ag/Au NPs, their capacity of antioxidant, bioavailability, antimicrobial, anti‐inflammatory, and anticancer.

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“…Voucher samples were deposited in the herbarium of Botanical Garden of Urbino University Carlo Bo: code “Pp125”. As for the extraction preparation, we followed the protocol previously described [ 13 ], except for one modification. In particular, we employed an acidified aqueous ethanol homogenizing solution (70 mL ethanol/29.9 mL distilled H 2 O/0.1 mL HCl 36%).…”

Section: Methodsmentioning

confidence: 99%

“…The work hypothesis was that Prunus extract could exert a positive effect on wound healing as its bioactive polyphenols exhibit antioxidant, anti-inflammatory, and antimicrobial properties [ 12 , 13 ], which makes the extract ideal to play such a role in tissue repair.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Inflammaging Ability of Prune (Prunus Spinosa L.) Extract Result in Improved Wound Healing Efficacy

et al. 2021

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Prunus spinosa L. fruit (PSF) ethanol extract, showing a peculiar content of biologically active molecules (polyphenols), was investigated for its wound healing capacity, a typical feature that declines during aging and is negatively affected by the persistence of inflammation and oxidative stress. To this aim, first, PSF anti-inflammatory properties were tested on young and senescent LPS-treated human umbilical vein endothelial cells (HUVECs). As a result, PSF treatment increased miR-146a and decreased IRAK-1 and IL-6 expression levels. In addition, the PSF antioxidant effect was validated in vitro with DPPH assay and confirmed by in vivo treatments in C. elegans. Our findings showed beneficial effects on worms’ lifespan and healthspan with positive outcomes on longevity markers (i.e., miR-124 upregulation and miR-39 downregulation) as well. The PSF effect on wound healing was tested using the same cells and experimental conditions employed to investigate PSF antioxidant and anti-inflammaging ability. PSF treatment resulted in a significant improvement of wound healing closure (ca. 70%), through cell migration, both in young and older cells, associated to a downregulation of inflammation markers. In conclusion, PSF extract antioxidant and anti-inflammaging abilities result in improved wound healing capacity, thus suggesting that PSF might be helpful to improve the quality of life for its beneficial health effects.

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Chemical composition, antioxidant, antimicrobial and anti-inflammatory activity of Prunus spinosa L. fruit ethanol extract

Cited by 53 publications

References 31 publications

Prunus spinosa Extract Loaded in Biomimetic Nanoparticles Evokes In Vitro Anti-Inflammatory and Wound Healing Activities

Prunus spinosa Extract Loaded in Biomimetic Nanoparticles Evokes In Vitro Anti-Inflammatory and Wound Healing Activities

Bioavailability and antioxidant activity of nanotechnology‐based botanic antioxidants

Antioxidant and Anti-Inflammaging Ability of Prune (Prunus Spinosa L.) Extract Result in Improved Wound Healing Efficacy

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