Chemical composition, antioxidant and gastrointestinal properties of Sedum dendroideum Moc &amp; Sessé ex DC leaves tea infusion

Luz, Bruna Barbosa da; Oliveira, Ana Flávia de; Maria-Ferreira, Daniele; Dallazen, Jorge Luiz; Cipriani, Thales R.; Souza, Lauro Mera de; Werner, Maria Fernanda de Paula

doi:10.1016/j.jep.2018.11.019

Cited by 11 publications

(8 citation statements)

References 33 publications

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“…Moreover, there's research that CYP 450 transgenic mice were used to prove that regulation of intestinal and hepatic drug-processing enzymes by the intestinal microbiota via tryptophan and its metabolites [36]. Kaempferol, as one of the active ingredients in Folium sennae filtered in network pharmacology in this study, increased small bowel transit in mice through cholinergic pathways [37] and regulated the metabolites involved in tryptophan [38]. So we come to the conclusion that Folium sennae targeted CYP 3A4 to altered intestinal microbiota microecology and intervened the tryptophan metabolism of intestinal microbiota, which may be one of the pharmacological mechanisms of laxative action of Folium sennae.…”

Section: Discussionmentioning

confidence: 79%

Role of tryptophan-metabolizing microbiota in mice diarrhea caused by Folium sennae extracts

Zhang

Shao

et al. 2020

BMC Microbiol

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Background: Although reports have provided evidence that diarrhea caused by Folium sennae can result in intestinal microbiota diversity disorder, the intestinal bacterial characteristic and specific mechanism are still unknown. The objective of our study was to investigate the mechanism of diarrhea caused by Folium sennae, which was associated with intestinal bacterial characteristic reshaping and metabolic abnormality. Results: For the intervention of Folium sennae extracts, Chao1 index and Shannon index were statistical decreased. The Beta diversity clusters of mice interfered by Folium sennae extracts were distinctly separated from control group. Combining PPI network analysis, cytochrome P450 enzymes metabolism was the main signaling pathway of diarrhea caused by Folium sennae. Moreover, 10 bacterial flora communities had statistical significant difference with Folium sennae intervention: the abundance of Paraprevotella, Streptococcus, Epulopiscium, Sutterella and Mycoplasma increased significantly; and the abundance of Adlercreutzia, Lactobacillus, Dehalobacterium, Dorea and Oscillospira reduced significantly. Seven of the 10 intestinal microbiota communities were related to the synthesis of tryptophan derivatives, which affected the transformation of aminotryptophan into L-tryptophan, leading to abnormal tryptophan metabolism in the host. Conclusions: Folium sennae targeted cytochrome P450 3A4 to alter intestinal bacterial characteristic and intervene the tryptophan metabolism of intestinal microbiota, such as Streptococcus, Sutterella and Dorea, which could be the intestinal microecological mechanism of diarrhea caused by Folium sennae extracts.

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Section: Discussionmentioning

confidence: 79%

Role of tryptophan-metabolizing microbiota in mice diarrhea caused by Folium sennae extracts

Zhang

Shao

et al. 2020

BMC Microbiol

View full text Add to dashboard Cite

show abstract

“…Moreover, there's research that CYP 450 transgenic mice were used to prove that regulation of intestinal and hepatic drugprocessing enzymes by the intestinal microbiota via tryptophan and its metabolites [36]. Kaempferol, as one of the active ingredients in Folium sennae filtered in network pharmacology in this study , increased small bowel transit in mice through cholinergic pathways [37] and regulated the metabolites involved in tryptophan [38]. So we come to the conclusion that Folium sennae targeted CYP 3A4 to altered intestinal microbiota microecology and intervened the tryptophan metabolism of intestinal microbiota, which may be one of the pharmacological mechanisms of laxative action of Folium sennae.…”

Section: Discussionmentioning

confidence: 78%

Role of Tryptophan-Metabolizing Microbiota On Diarrhea Mice Caused by Folium sennae Extracts

Zhang

Shao

et al. 2020

Preprint

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Abstract Background: Although reports have provided evidence that diarrhea caused by Folium sennae can result in intestinal microbiota diversity disorder, the intestinal bacterial characteristic and specific mechanism are still unknown. The objective of our study was to investigate the mechanism of diarrhea caused by Folium sennae, which was associated with intestinal bacterial characteristic reshaping and metabolic abnormality. Results: For the intervention of Folium sennae extracts, Chao1 index and Shannon index were statistical decreased. The Beta diversity clusters of mice interfered by Folium sennae extracts were distinctly separated from control group. Combining PPI network analysis, cytochrome P450 enzymes metabolism was the main signaling pathway of diarrhea caused by Folium sennae. Moreover, 10 bacterial flora communities had statistical significant difference with Folium sennae intervention: the abundance of Paraprevotella, Streptococcus, Epulopiscium, Sutterella and Mycoplasma increased significantly; and the abundance of Adlercreutzia, Lactobacillus, Dehalobacterium, Dorea and Oscillospira reduced significantly. 7 of the 10 intestinal microbiota communities were related to the synthesis of tryptophan derivatives, which affected the transformation of aminotryptophan into L-tryptophan, leading to abnormal tryptophan metabolism in the host. Conclusions: Folium sennae targeted cytochrome P450 3A4 to alter intestinal bacterial characteristic and intervene the tryptophan metabolism of intestinal microbiota, such as Streptococcus, Sutterella and Dorea, which could be the intestinal microecological mechanism of diarrhea caused by Folium sennae extracts.

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“…Furthermore, kaempferol, myricetin, and quercetin glycosides have been reported in species from the Crassulaceae family [30][31][32][33][34][35]. Myricetin, quercetin, and kaempferol aglycone from S. dendroideum have been linked to antioxidant, anti-inflammatory, antinociceptive, and gastroprotective activity [1,2,4,11].…”

Section: Discussionmentioning

confidence: 99%

“…S. dendroideum is a species commonly used in Brazilian and Mexican traditional medicine due to its analgesic, antimicrobial, and gastroprotective properties. Previous scientific reports proved its activity against pain (antinociceptive) in an induced peritonitis model, antioxidant activity used as a fresh leaf infusion, antiglycemic effect in diabetic mice, anti-inflammatory activity in vitro due to its ability to stimulate macrophages to produce cytokines, and gastroprotective effect in vivo [1][2][3][4]. ese properties are related to vegetal secondary metabolites, including flavonoids glycosides, tannins, kaempferol, quercetin, and phenols.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profile and Antioxidant and Antiproliferative Activity of Sedum dendroideum on Pterygium Fibroblasts

López-Montemayor

Zavala

Montalvo-Parra

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Sedum dendroideum has antioxidant effects that are beneficial for different diseases. We aimed to analyze the antiproliferative activity of S. dendroideum in human pterygium fibroblasts (HPFs). Methods. HPFs were treated for 24 h with 0–1000 μg/mL of S. dendroideum lyophilized to analyze its effect on cell viability using the CellTiter assay. RNA from HPF treated with 250 μg/mL of S. dendroideum lyophilized was isolated, and the expression of VEGF and CTGF genes was evaluated by qPCR. A dermal fibroblast cell line (HDFa) was used as a healthy control. The total phenolic content, antioxidant activity, and chemical profile of S. dendroideum lyophilized were determined. Results. Viability of HPF decreased after 24 h treatment of S. dendroideum in a dose-dependent manner. The expression of VEGF and CTGF significantly decreased ( P < 0.01 ) in HPF treated with 250 μg/mL of S. dendroideum when compared with untreated HPF. The total phenolic concentration in the S. dendroideum lyophilized was 33.67 mg gallic acid equivalents (GAE)/g. Antioxidant activity was 384.49 mM Trolox equivalents/mL. The main phenolic compounds identified by HPLC analysis were the kaempferol-3-O-glycoside, kaempferol-3-O-rhamnoside, kaempferol-3-O-neohesperidoside-7-O-α-rhamnopyranoside, and kaempferol-3-O-glycoside-7-O-rhamnoside. Conclusions. S. dendroideum decreases the proliferation of HPF and the expression of VEGF and CTGF. The phenolic compound concentration, antioxidant activity, and phytochemical profile may play a role in these effects.

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Chemical composition, antioxidant and gastrointestinal properties of Sedum dendroideum Moc & Sessé ex DC leaves tea infusion

Cited by 11 publications

References 33 publications

Role of tryptophan-metabolizing microbiota in mice diarrhea caused by Folium sennae extracts

Role of tryptophan-metabolizing microbiota in mice diarrhea caused by Folium sennae extracts

Role of Tryptophan-Metabolizing Microbiota On Diarrhea Mice Caused by Folium sennae Extracts

Phytochemical Profile and Antioxidant and Antiproliferative Activity of Sedum dendroideum on Pterygium Fibroblasts

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