Chemical composition, antioxidant and antibacterial activity of <i>Crataegus monogyna</i> leaves’ extracts

Belabdelli, Fouzia; Bekhti, Nabila; Piras, Alessandra; Benhafsa, Fouad Mekhalef; Ilham, Mokhtari; ADİL, Selka; Anes, Lazzaz

doi:10.1080/14786419.2021.1958215

Cited by 16 publications

(12 citation statements)

References 19 publications

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“…Similarly, the IC 50 values are in the order of 1.86 ± 0.01 mg/mL and 9.23 ± 0.01 mg/mL for ascorbic acid, and C monogyna, respectively. Our results demonstrated that the aqueous extract of C monogyna had less radical trapping activity than the ethanolic extract of IC 50 leaves (22.5 µg/mL) found by Fouzia et al 31 Furthermore, Amor and Belhattab 39 reported an IC 50 of C monogyna aqueous leaf extract ranging from 45 to 725 µg/mL at different vegetation stages. Coimbra et al 40 reported that the extracts obtained from C monogyna demonstrated an IC 50 value of 36.11 g/mL.…”

Section: High-performance Liquid Chromatography Coupled With Diode Ar...supporting

confidence: 39%

“…23 Quinic acid and its derivatives such as caffeoylquinic acids are also responsible for the astringent sensation and have also been isolated from C monogyna . 27,28…”

Section: Resultsmentioning

confidence: 99%

“…Keser et al 35 reported that the aqueous extracts of the leaves and flowers of C monogyna are rich in rutin-type flavonoids, and other types of flavonoids. In addition, Belabdelli et al 31 identified 9 procyanidine telic phenolic compounds, epicatechina, catechin, chlorogenic acid, caffeic acid, vitexin-2- O -rhamnoside, vitexin, rutin, and hyperoside in an ethanolic extract of C monogyna leaves. The same authors identified syringic acid, myricetine, quercetin, naringenin, kaempferol, using the chloroform extract of C monogyna leaves.…”

Section: Resultsmentioning

confidence: 99%

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Phytochemical Analysis, Antioxidant, and Antihyperglycemic Activities ofCrataegus monogynaJacq Aqueous Extract

Radi,

Bencheikh,

Bouhrim

et al. 2023

Natural Product Communications

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Objective This study aims to evaluate the phytochemical composition, antioxidant, and antihyperglycemic (in vivo, in vitro, and in silico) activities and acute toxicity of Crataegus monogyna Jacq ( C monogyna) aqueous extracts. Methods The study analyzed the aqueous extract of C monogyna through various methods such as phytochemical screening, and the high-performance liquid chromatography-ultraviolet (HPLC-UV)-visible analysis. The extract was also tested for antioxidant potential, acute toxicity, antihyperglycemic effect, and inhibitory effect on the pancreatic α-amylase enzyme. Additionally, the study used the molecular docking approach to identify the most potent ligands in the extract. Results The phytochemical screening of the aqueous extract of C monogyna showed the presence of flavonoids, tannins, coumarins, sterol, and triterpene. The extract was rich in total polyphenols (1.65 ± 0.04 mg gallic acid equivalent per gram of extract [GAE/g] DM), total flavonoids (0.33 ± 0.03 EQ/g DM), and condensed tannins (0.28 ± 0.01 EC/mg DM). HPLC-UV-visible analysis identified 9 phenolic compounds, with high levels of gallic acid and caffeic acid. The C monogyna extract has a high antioxidant activity with an IC50 of 9.23 ± 0.01 mg/mL by DPPH and 8.32 ± 0.02 mg/mL by FRAP. The aqueous extract of C monogyna was not toxic to albino mice. The glucose tolerance test showed a significant antihyperglycemic effect, with an IC50 of 0.070 ± 0.008 mg/mL for the inhibition of pancreatic α-amylase activity by the aqueous extract of C monogyna. The in vivo inhibitory effect of the extract on the pancreatic α-amylase enzyme was confirmed. Two flavonoids, catechin, and rutin, were identified as potent inhibitors of the activity of α-amylase in the in silico part of the study, compared to the native ligand, Acarbose. Conclusion The study found that C monogyna has significant antioxidant and antihyperglycemic properties. The presence of catechin and rutin may contribute to these effects. The results suggest that C monogyna could be used as a dietary supplement to prevent and treat diabetes.

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Section: High-performance Liquid Chromatography Coupled With Diode Ar...supporting

confidence: 39%

“…23 Quinic acid and its derivatives such as caffeoylquinic acids are also responsible for the astringent sensation and have also been isolated from C monogyna . 27,28…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Phytochemical Analysis, Antioxidant, and Antihyperglycemic Activities ofCrataegus monogynaJacq Aqueous Extract

Radi,

Bencheikh,

Bouhrim

et al. 2023

Natural Product Communications

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show abstract

“…For example, the ethanolic extract of Crataegus monogyna leaf has antimicrobial activity against Staphylococcus aureus , having its MIC 0.512–1.024 mg/mL. However, extractions using this leaf with an aqueous solvent also showed antimicrobial activity for the E. coli species, which, on the other hand, with the ethanolic extract, did not demonstrate any activity [ 194 ]. Organic CHCl3/MeOH extracts from H. glomerata leaves showed antibacterial activity against Staphylococcus aureus and Enterococcus faecium and the resistant bacteria K. pneumoniae extended-spectrum β-lactamases (ESBL) [ 195 ].…”

Section: Plant Extractsmentioning

confidence: 99%

Biosynthesis of Nanoparticles Using Plant Extracts and Essential Oils

Filho

Santos

et al. 2023

Molecules

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Plant extracts and essential oils have a wide variety of molecules with potential application in different fields such as medicine, the food industry, and cosmetics. Furthermore, these plant derivatives are widely interested in human and animal health, including potent antitumor, antifungal, anti-inflammatory, and bactericidal activity. Given this diversity, different methodologies were needed to optimize the extraction, purification, and characterization of each class of biomolecules. In addition, these plant products can still be used in the synthesis of nanomaterials to reduce the undesirable effects of conventional synthesis routes based on hazardous/toxic chemical reagents and associate the properties of nanomaterials with those present in extracts and essential oils. Vegetable oils and extracts are chemically complex, and although they are already used in the synthesis of nanomaterials, limited studies have examined which molecules are effectively acting in the synthesis and stabilization of these nanostructures. Similarly, few studies have investigated whether the molecules coating the nanomaterials derived from these extracts and essential oils would bring benefits or somehow reduce their potential activity. This synergistic effect presents a promising field to be further explored. Thus, in this review article, we conducted a comprehensive review addressing the main groups of molecules present in plant extracts and essential oils, their extraction capacity, and available methodologies for their characterization. Moreover, we highlighted the potential of these plant products in the synthesis of different metallic nanomaterials and their antimicrobial capacity. Furthermore, we correlated the extract’s role in antimicrobial activity, considering the potential synergy between molecules from the plant product and the different metallic forms associated with nanomaterials.

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“…Crataegus monogyna , commonly known as hawthorn, is a round appearing medicinal tree with a cream flower that turns dark red in autumn ( Fichtner and Wissemann, 2021 ; Martinelli et al, 2021 ; Belabdelli et al, 2022 ). C. monogyna is a fantastic source of active ingredients, including a wide range of polyphenols, including epicatechin, procyanidins, isoquercitrin, hyperoside, and chlorogenic acid, as well as a wide range of triterpene acids, including ursolic acid and oleanolic acid, and many others ( Bahorun et al, 1994 ; Nabavi et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of Crataegus monogyna inhibitors against breast cancer

et al. 2023

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Breast cancer is a silent killer disorder among women and a serious economic burden in healthcare management. Every 19 s, a woman is diagnosed with breast cancer, and every 74 s, a woman worldwide passes away from the disease. Despite the increase in progressive research, advanced treatment approaches, and preventive measures, breast cancer rates continue to increase. This study provides a combination of data mining, network pharmacology, and docking analysis that surely could revolutionize cancer treatment by exploiting prestigious phytochemicals. Crataegus monogyna is a small, rounded deciduous tree with glossy, deeply lobed leaves and flat sprays of cream flowers, followed by dark red berries in autumn. Various studies demonstrated that C. monogyna is therapeutically effective against breast cancer. However, the particular molecular mechanism is still unknown. This study is credited for locating bioactive substances, metabolic pathways, and target genes for breast cancer treatment. According to the current investigation, which examined compound–target genes–pathway networks, it was found that the bioactive compounds of C. monogyna may operate as a viable solution against breast cancer by altering the target genes implicated in the disease pathogenesis. The expression level of target genes was analyzed using GSE36295 microarray data. Docking analysis and molecular dynamic simulation studies further strengthened the current findings by validating the effective activity of the bioactive compounds against putative target genes. In summary, we propose that six key compounds, luteolin, apigenin, quercetin, kaempferol, ursolic acid, and oleanolic acid, contributed to the development of breast cancer by affecting the MMP9 and PPARG proteins. Integration of network pharmacology and bioinformatics revealed C. monogyna’s multitarget pharmacological mechanisms against breast cancer. This study provides convincing evidence that C. monogyna might partially alleviate breast cancer and ultimately lays a foundation for further experimental research on the anti-breast cancer activity of C. monogyna.

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Chemical composition, antioxidant and antibacterial activity of Crataegus monogyna leaves’ extracts

Cited by 16 publications

References 19 publications

Phytochemical Analysis, Antioxidant, and Antihyperglycemic Activities ofCrataegus monogynaJacq Aqueous Extract

Phytochemical Analysis, Antioxidant, and Antihyperglycemic Activities ofCrataegus monogynaJacq Aqueous Extract

Biosynthesis of Nanoparticles Using Plant Extracts and Essential Oils

Therapeutic effects of Crataegus monogyna inhibitors against breast cancer

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