Chemical composition, angiotensin I-converting enzyme inhibitory, antioxidant and antimicrobial activities of essential oil of Tunisian Thymus algeriensis Boiss. et Reut. (Lamiaceae)

Zouari, Nacim; Fakhfakh, Nahed; Zouari, Sami; Bougatef, Ali; Aida, Kô; Neffati, Mohamed; Ayadi, Mohamed Ali

doi:10.1016/j.fbp.2010.11.006

Cited by 80 publications

(57 citation statements)

References 41 publications

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“…On the contrary, it was reported that essential oil of Tunisan Th. algeriensis displayed relatively high DPPH radical-scavenging activity, despite of absence of thymol and carvacrol [18]. These results imply that non-phenolic contents could be also responsible for this activity.…”

Section: Antioxidant Activitymentioning

confidence: 59%

“…algeriensis essential oil possessed a strong antioxidant activity with IC 50 =0.299 mg/ml, and it was better than thymol 0.403 mg/ml and less than carvacrol (IC 50 =0.105 mg/ml). That can be attributed to the high percentage of oxygenated monoterepenes, especially thymol and carvacrol [18], which together represent 43.19% of the total oil. The oil also showed lower antioxidant activity than BHA.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…There are a number of reports on the chemical composition of essential oil of Th. algeriensis, with a large variation in the chemical profile established [3,4,[15][16][17][18]. There is only one earlier study of the chemical composition and antimicrobial activities of this species from Libya [15].…”

Section: Introductionmentioning

confidence: 99%

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Chemical composition, antioxidant and antimicrobial activities of essential oil of Thymus algeriensis wild-growing in Libya

et al. 2013

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The composition of essential oil isolated from Thymus algeriensis growing wild in Libya was analyzed by GC and GC-MS. The essential oil was characterized with thymol (38.50%) as the major component. The oil was screened for antioxidant activity using DPPH assay, and compared to thymol and carvacrol. Antioxidant activity was high, with the IC50 of 0.299 mg/ml, compared to 0.403 and 0.105 mg/ml for thymol and carvacrol, and 0.0717 mg/ml for BHA. In addition, antimicrobial activity was tested against eight bacteria and eight fungi. T. algeriensis oil showed inhibitory activity against tested bacteria at 0.001–0.05 mg/ml, while bactericidal activity (MBC) was achieved at 0.0025–0.05 mg/ml. For antifungal activity MICs ranged 0.0005–0.025 mg/ml and MFC 0.001–0.05 mg/ml. High antimicrobial activity against the fungi in particular suggests that the essential oil of Thymus algeriensis could have a useful practical application.

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Section: Antioxidant Activitymentioning

confidence: 59%

Section: Antioxidant Activitymentioning

confidence: 99%

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Chemical composition, antioxidant and antimicrobial activities of essential oil of Thymus algeriensis wild-growing in Libya

et al. 2013

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“…Notably, four of these six compounds were oxygenated monoterpenes (oxygenated monoterpene 1, sabinene hydrate, camphor, and α-terpineol), a class of terpenoids noted for strong antifungal activity, usually more fungistatic than nonoxygenated monoterpenes. (Bakkali et al 2008;Hussain et al 2011;Jiao et al 2012;Zouari et al 2011). Most of the de novo compounds were detected in relatively low concentrations (0.09-0.36 mg g −1 dw) except for de novo 3, a diterpene that had a mean concentration of 5.4 mg g −1 but was rarely detected.…”

Section: Discussionmentioning

confidence: 99%

Strong Induction of Minor Terpenes in Italian Cypress, Cupressus sempervirens, in Response to Infection by the Fungus Seiridium cardinale

Achotegui-Castells

Danti²,

Llusià

et al. 2015

J Chem Ecol

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Seiridium cardinale, the main fungal pathogen responsible for cypress bark canker, is the largest threat to cypresses worldwide. The terpene response of canker-resistant clones of Italian cypress, Cupressus sempervirens, to two differently aggressive isolates of S. cardinale was studied. Phloem terpene concentrations, foliar terpene concentrations, as well as foliar terpene emission rates were analyzed 1, 10, 30, and 90 days after artificial inoculation with fungal isolates. The phloem surrounding the inoculation point exhibited de novo production of four oxygenated monoterpenes and two unidentified terpenes. The concentrations of several constitutive mono-and diterpenes increased strongly (especially α-thujene, sabinene, terpinolene, terpinen-4-ol, oxygenated monoterpenes, manool, and two unidentified diterpenes) as the infection progressed. The proportion of minor terpenes in the infected cypresses increased markedly from the first day after inoculation (from 10 % in the control to 30-50 % in the infected treatments). Foliar concentrations showed no clear trend, but emission rates peaked at day 10 in infected trees, with higher δ-3-carene (15-fold) and total monoterpene (10-fold) emissions than the control. No substantial differences were found among cypresses infected by the two fungal isolates. These results suggest that cypresses activate several direct and indirect chemical defense mechanisms after infection by S. cardinale.

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“…The essential oil known as thyme oil is used in the food flavoring and preservatives (Ehivet et al, 2011), perfumery and pharmaceutical industries (Ballester-Costa et al, 2013). Analysis of the essential oils from different species indicated the presence of different components mainly the high phenolic monoterpenes such as carvacrol, thymol and α-terpineol (Ehivet et al, 2011;Zouari et al, 2011) and solvent extracts contain many phenolic acids such as rosmarinic, ferulic, caffeic, chlorogenic and p-coumaric acids and also different flavonoids (Iness et al, 2012;Zeghad and Merghem, 2013). The essential oils exhibited strong antioxidant (Iness et al, 2012), antifungal (Eugénia et al, 2013) and antibacterial (Fethi et al, 2013) activities.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and -amylase inhibition activities in vitro of various solvent extracts of Thymus schimperi Ronniger

Dessalegn¹,

Bultosa²,

Haki³

et al. 2015

J. Med. Plants Res.

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Thymus schimperi Ronniger is a wild endemic herb to Ethiopia, and is traditionally used as food flavoring, preservative as well as medicinal ingredient. This paper reports the total phenolic and flavonoid contents, antioxidant capacity and α-amylase inhibition activity of various solvent extracts of the dried leaves. The acetone extracts contained the highest total phenolic content (122.0±11.6 mg GAE/g). Total flavonoid content was the highest in methanol extract (45.1±2.9 mg QRE/g). The aqueous methanol extract showed the highest 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging ability (IC 50 =11.0±1.0 µg/ml), iron reducing power (60.1±1.0 mg AAE/g), and total antioxidant capacity (1.1±0.1 mg BHTE/g). The water extract exhibited the highest iron chelating activity (IC 50 = 65.4±1.1 µg/ml) while the methanol extract exhibited the highest percentage of α-amylase inhibition activity (IC 50 = 335. 6±90.4 µg/ml). Except for iron chelating activity, all antioxidant activities were positively correlated with total phenolic and flavonoid contents. The study revealed that antioxidant and α-amylase inhibitory activities of the crude extract were variable when extracted by different solvents indicating a high potential to be used as natural antioxidants in food preservation as well as for preventing oxidative stress mediated human disorders.

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Chemical composition, angiotensin I-converting enzyme inhibitory, antioxidant and antimicrobial activities of essential oil of Tunisian Thymus algeriensis Boiss. et Reut. (Lamiaceae)

Cited by 80 publications

References 41 publications

Chemical composition, antioxidant and antimicrobial activities of essential oil of Thymus algeriensis wild-growing in Libya

Chemical composition, antioxidant and antimicrobial activities of essential oil of Thymus algeriensis wild-growing in Libya

Strong Induction of Minor Terpenes in Italian Cypress, Cupressus sempervirens, in Response to Infection by the Fungus Seiridium cardinale

Antioxidant and -amylase inhibition activities in vitro of various solvent extracts of Thymus schimperi Ronniger

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