Chemical Composition and Possible in Vitro Phytotoxic Activity of Helichrsyum italicum (Roth) Don ssp. italicum

Mancini, Emilia; Martino, Laura De; Marandino, Aurelio; Scognamiglio, Mariarosa; Feo, Vincenzo De

doi:10.3390/molecules16097725

Cited by 39 publications

(33 citation statements)

References 41 publications

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“…Consequently, studies reporting its composition are numerous (Angioni et al, 2003;Bertoli et al, 2012;Bianchini et al, 2009;Bianchini et al, 2004;Bianchini et al, 2003;Bianchini et al, 2001;Conti et al, 2010;Leonardi et al, 2013;Mancini et al, 2011;Mastelic et al, 2008;Mastelic et al, 2005;Morone-Fortunato et al, 2010;Paolini et al, 2006;Perrini et al, 2009;Roussis et al, 2000;Satta et al, 1999;Usai et al, 2010 (Bianchini et al, 2001;Paolini et al, 2006), another constituted by a high amount of geraniol and geranyl acetate (Bianchini et al, 2001;Morone-Fortunato et al, 2010), and a third one with a large proportion of sesquiterpenes (Bianchini et al, 2001;Morone-Fortunato et al, 2010). Regarding H. italicum subsp.…”

Section: Plant Extracts and Chemical Compositionmentioning

confidence: 99%

Helichrysum italicum: From traditional use to scientific data

Viegas¹,

Palmeira‐de‐Oliveira²,

Salgueiro³

et al. 2014

Journal of Ethnopharmacology

132

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Ethnopharmacological relevanceHelichrysum italicum (Roth) G. Don fil. (family Asteraceae) has been used for its medicinal properties for a long time and, even nowadays, continues to play an important role in the traditional medicine of Mediterranean countries. Based on this traditional knowledge, its different pharmacological activities have been the focus of active research. Aim of the reviewTo provide an overview of the current state of knowledge of the pharmacological activities of H. italicum, as well as its traditional uses, toxicity, drug interactions and safety. Materials and methodsThe selection of relevant data was made through a search using the keywords "Helichrysum italicum" and "H. italicum" in "Directory of Open Access Journals", "Google Scholar", "ISI Web of Knowledge", "PubMed", "ScienceDirect" and "Wiley Online Library". Information obtained in local and foreign books and other sources was also included. ResultsThere are reports on the traditional use of H. italicum in European countries, particularly Italy, Spain, Portugal and Bosnia and Herzegovina. In these countries, its flowers and leaves are the most used parts in the treatment of health disorders such as allergies, colds, cough, skin, liver and gallbladder disorders, inflammation, infections and sleeplessness. In order to validate some of the traditional uses of H. italicum italicum in vivo activity, the highlight goes to the anti-erythematous and photoprotective activities of its flavonoids, demonstrated both in animals and humans, and to the anti-inflammatory properties exhibited by its flavonoids, acetophenones and phloroglucinols, as seen in animal models. Concerning its safety and adverse effects, while H. italicum does not display significant levels of cytotoxicity or genotoxicity, it should be noticed that one of its flavonoids inhibited some CYP isoforms and a case has been reported of an allergic reaction to its extracts. Aim of the reviewTo provide an overview of the current state of knowledge of the pharmacological activities of H. italicum, as well as its traditional uses, toxicity, drug interactions and safety. Materials and methodsThe selection of relevant data was made through a search using the keywords "Helichrysum italicum" and "H. italicum" in "Directory of Open Access Journals", "Google Scholar", "ISI Web of Knowledge", "PubMed", "ScienceDirect" and "Wiley Online Library". Information obtained in local and foreign books and other sources was also included. ResultsThere are reports on the traditional use of H. italicum in European countries, particularly Italy, Spain, Portugal and Bosnia and Herzegovina. In these countries, its flowers and leaves are the most used parts in the treatment of health disorders such as allergies, colds, cough, skin, liver and gallbladder disorders, italicum in vivo activity, the highlight goes to the anti-erythematous and photoprotective activities of its flavonoids, demonstrated both in animals and humans, and to the anti-inflammatory properties exhibited by its flavonoids, acet...

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Section: Plant Extracts and Chemical Compositionmentioning

confidence: 99%

Helichrysum italicum: From traditional use to scientific data

Viegas¹,

Palmeira‐de‐Oliveira²,

Salgueiro³

et al. 2014

Journal of Ethnopharmacology

132

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“…For these reasons, our research group carried out a series of studies on the possible biological properties of aromatic plants that are rich in active principles and are considered a primary source of potential active compounds [7][8][9][10][11][12]. Furthermore, considering the interest in natural products for different commercial fields, a thorough knowledge of the biological and safety profiles of essential oils can also provide results of economic importance [13].…”

Section: Aromatic Plants In the Mediterranean Dietmentioning

confidence: 99%

Essential Oils from Mediterranean Aromatic Plants

Martino

Nazzaro

Mancini

et al. 2015

The Mediterranean Diet

Self Cite

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“…Some Helichrysum species are also found in South‐West Asia, southern India, Sri Lanka and Australia . Members of the genus Helichrysum (Asteraceae) are usually aromatic herbs or dwarf perennial shrubs, growing at a wide range of altitudes from the sea level up to 1700 m a.s.l., preferably on sandy or loamy soils . The plants have a high level of polymorphism, mainly in the habitus, leaves and flowers …”

Section: Introductionmentioning

confidence: 99%

Essential Oil Composition and Volatile Profile of Seven Helichrysum Species Grown in Italy

Giovanelli

Leo

Cervelli

et al. 2018

Chemistry & Biodiversity

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Helichrysum genus consists of about 600 species widespread throughout the world, especially in South Africa and in the Mediterranean area. In this study the aroma profile (HS-SPME) and the EO compositions of seven Helichrysum species (H. cymosum, H. odoratissimum, H. petiolare, H. fontanesii, H. saxatile, H. sanguineum, and H. tenax) were evaluated. All the plants were grown in Italy under the same growth conditions. The volatile constituents, particularly monoterpenes, depended by the plant's genotype and ecological adaptation. This study represents the first headspace evaluation on the selected plants and the results evidenced that monoterpenes represented the main class of constituents in five of the seven species analysed (from 59.2% to 95.0%). The higher content in sesquiterpene hydrocarbons was observed in the Mediterranean species of H. sanguineum (68.0%). Only H. saxatile showed relative similar abundance of monoterpenes and sesquiterpene hydrocarbons. The essential oil composition of the majority of examined species are characterised by high percentage of sesquiterpenes (especially β-caryophyllene and δ-cadinene) ranging from 51.3% to 92.0%, except for H. cymosum, H. tenax, and H. sanguineum leaves where monoterpenes predominated (from 51.7% to 74.7%).

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Chemical Composition and Possible in Vitro Phytotoxic Activity of Helichrsyum italicum (Roth) Don ssp. italicum

Cited by 39 publications

References 41 publications

Helichrysum italicum: From traditional use to scientific data

Helichrysum italicum: From traditional use to scientific data

Essential Oils from Mediterranean Aromatic Plants

Essential Oil Composition and Volatile Profile of Seven Helichrysum Species Grown in Italy

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