Chemical composition and medicinal properties of Nigella sativa Linn.

Ma, Kun

doi:10.1007/s10787-999-0023-y

Cited by 169 publications

(111 citation statements)

References 47 publications

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“…This may be from the anti-inflammatory effect of NS. This effect may be consistent with the inhibitory effects of thymoquinone and other components of NS on many inflammatory mediators (Khan 1999;Bourgou et al 2010). Both the crude fixed oil of NS and purethymoquinone inhibited cyclooxygenase and 5-lipoxygenase pathways of arachidonate metabolism in rat peritoneal leukocytes (Houghton et al 1995).…”

Section: Discussionsupporting

confidence: 71%

“…Thymoquinone, pcymene (monoterpene), longifolene (sesquiterpene) and thymohydroquinone were the compounds responsible for the strong antimicrobial activity of NS (Bourgou et al 2010). In addition, Thymoquinone or thymohydroquinone are active components of the seed that have different pharmacological activities such as anti-inflammatory and antioxidant effects (Khan 1999). Antioxidant and anti-inflammatory activity of the NS may enhance phagocytic activity by protecting the phagocytic cell (Salem 2005); so it can play therapeutic roles in reducing microorganisms.…”

Section: Discussionmentioning

confidence: 99%

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Antimicrobial, anti-inflammatory and antioxidant activity ofNigella sativain clinically endometritic cows

Yıldız

Balikci

2015

Journal of Applied Animal Research

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The aim of this study was to investigate the response to intrauterine infusion of Nigella sativa (NS) and ceftiofur and to evaluate the possible antimicrobial, antioxidant and anti-inflammatory effects of NS in clinically endometritic cows. A total of 30 clinically endometritic cows (10 cows in each group) were randomly divided into 3 treatment groups: an i.u. infusion of 100 mL of methanol extract of NS was given once a day during 3 days in group NS; an i.u. infusion of a 20-mL suspension (Excenel®, Pfizer) containing 1 g of ceftiofur as ceftiofur hydrochloride was given once a day during three days in group CH; cows with no treatment belonged to group C. After the treatment, there were slight vaginal discharges in 3/10 animals in group NS and 2/10 animals in group CH. GSH-Px and superoxide dismutase levels increased and malondialdehyde concentration decreased significantly (P < .05) in groups NS and CH after treatment when compared to pretreatment ones. Hp and SAA levels of groups NS and CH decreased significantly (P < .05) after treatment when compared to group C. NS had antimicrobial, antioxidant and antiinflamatory effects in clinical endometric cows. Although the antimicrobial effect of NS was less than that of CH, this study indicates a therapeutic value of NS in clinically endometritic cows. NS might be a promising therapy for cows with clinical endometritis in the future. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Antimicrobial, anti-inflammatory and antioxidant activity ofNigella sativain clinically endometritic cows

Yıldız

Balikci

2015

Journal of Applied Animal Research

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“…This quinone is a calcium channel blocker, and drugs in this group are frequently used to help opiate addicts overcome their addiction. [19][20][21] In the work presented here in, a rapid and accurate method for the fast and simultaneous qualitative and quantitative characterization of natural products and their constituents, 22 namely Attenuated Total Reflection-Fourier-Transform Infrared spectroscopy (ATR-FTIR), and three thermo analytical techniques (viz., thermo gravimetry (TG/DTG), differential thermal analysis (DTA) and differential scanning calorimetry (DSC)) have been used to study the chemical properties and thermal behavior of the three aforementioned seeds.…”

Section: On the Interaction Of Seed Components And Opiate Receptorsmentioning

confidence: 99%

Vibrational Analysis and Thermal Behavior of Salvia hispanica, Nigella sativa and Papaver somniferum Seeds

Carrión-Prieto¹,

Martín-Ramos²,

Hernández-Navarro³

et al. 2017

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Introduction: Salvia hispanica L., Nigella sativa L. and Papaver somniferum L. are involved in opiate-dependent behavior. It is known that the seeds of these three herbs contain high amounts of antioxidants, which are helpful in disease prevention, but further research is needed on some of their other phytochemical components (terpene alkaloids, benzoquinones and others), which are claimed to affect human opioid receptors. Methods: Seeds from the three afore mentioned plants have been studied by ATR-FTIR vibrational spectroscopy and thermo analytical techniques (TG/DTG, DTA and DSC). Results: The infrared spectrum has confirmed the presence of the ester carbonyl of terpenoid alkaloids (such as nigellamine) and the fully conjugated cyclic dione structure of quinones (e.g., thymoquinone). As regards the thermal stability of these seeds, small differences have been observed in their thermal profiles (endothermic effects at around 333ºC for chia, 268ºC for black cumin and 319ºC for poppy seeds), which can be ascribed to their different content in carbohydrates. Conclusions: The functional groups of the main active constituents and the thermal behavior of these three seeds have been elucidated.

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“…This could be due to black cumin seed possessed antifungal activity (Islam et al, 1989). According to Khan (1999) stated that, black cumin (kalojira seed) seed has many medicinal properties such as bronchodilatory, hypotensive, antibacterial, antifungal, analgesic, anti-inflamatory and immunopotentiating and were universally accepted as a panacea. The volatile oil of the seed possessed antibacterial activity against multiple drugs resistant bacteria including vibrio cholerae (Ferdous et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

Performance of Herbal Extracts on Diseased Fish

Alam

Ahmed

Chowdhury

2014

Bangl. J. Vet. Med.

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An experiment was conducted for a period of 28 days to observe the effect of plant extracts on recovery of fish diseases. The experiment was carried out in mini pond (1.75 decimal) behind the Fisheries Faculty in BAU, Mymensingh. Twelve hapas (3 ×2 ×1.5 sq.ft.) and five studies were conducted with control hapa with 3 treatments and two replicates each. Four medicinal plant products were collected and prepared. In study 1 fishes were treated with Neem Seed Oil, study 2 with Kalojira Seed Oil, study 3 with Neem Leaf Extract, study 4 with Mahogoni Seed Oil and the control hapa was provided with normal feed. The treatments were practiced as 2ml, 4ml and 6ml per kg feed. At the beginning of the experiment, fishes had red spots on dorsal and caudal region, scale missing, large abrasions and black to grayish spots. In Kalojira Seed Oil (study 2) treated fish, spots and lesions were totally recovered in T2 and T3 whereas in T1 there were traces spots at the end of the experiment. However, in Neem Seed Oil and Neem Leaf fine extract treated fish (study 1 and study 3), injury, abrasions and lesions were almost healed up in T3 (6ml/kg feed) and moderate recovery in T2 and T1. In Mahogoni Seed Oil (study 4) treated fish, ulcers and lesions were reduced in size but existed distinctly in all the treatments at the end of the experiment. In control study (study 5) injury and abrasions had no recovery but remained almost similar till the end of experiment. Thus it was found that Kalojira Seed Oil performed best recovery (90-95%) followed by Neem Seed Oil (78-84%), Neem Leaf fine extract (70-75%) and poor performance was observed with Mahogoni Seed Oil extract (35-40%). So, kalojira seed oil was the best performed herb and T3 (6ml/kg feed) was the best dose followed by T1 and T2.

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Chemical composition and medicinal properties of Nigella sativa Linn.

Cited by 169 publications

References 47 publications

Antimicrobial, anti-inflammatory and antioxidant activity ofNigella sativain clinically endometritic cows

Antimicrobial, anti-inflammatory and antioxidant activity ofNigella sativain clinically endometritic cows

Vibrational Analysis and Thermal Behavior of Salvia hispanica, Nigella sativa and Papaver somniferum Seeds

Performance of Herbal Extracts on Diseased Fish

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