Chemical Composition and Inhibitory Effects ofGuibourtia coleospermaagainst Plasmodium Parasites In Vitro

Preez, Iwanette du; Louw, Stefan; Mumbengegwi, Davis R.

doi:10.1021/bk-2020-1361.ch007

Cited by 2 publications

(2 citation statements)

References 60 publications

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“…Compound 3 was also isolated from a Leguminosae plant Trigonella foenumgraecum (Idris et al, 2021), indicating a close relationship between genus Guibourtia and Trigonella; however, further investigation must be done to support these observations. Lanosterol (8) was identified using gas chromatography-mass spectrometry from G. colosperma (Preez et al, 2020). Lupeol (5), taraxerol (6) and friedelan-3-one ( 7) are isolated for the first time from the Guibourtia genus but were previously detected in other genera from Leguminosae (Fabaceae) family.…”

Section: Chemotaxonomic Significancementioning

confidence: 99%

Phytochemical compounds of Guibourtia ehie and their antioxidant, urease and α-glucosidase inhibitory activities

Bongmo¹,

Happi²,

Tabekoueng³

et al. 2022

NRFHH

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Thirteen compounds (1‒13) were isolated and identified during phytochemical analysis of the leaves and stem bark of Guibourtia ehie (A. Chev) J. Leonard. Spectroscopic and spectrometric methods and the comparison of their results with those given in the literature were used to ascertain their structures. Furthermore, the acetylation of 3,3′-di-O-methylellagic acid 4′-O-β-D-xylopyranoside (2) afforded a new derivative 3,3′-di-O-methylellagic acid 4′-O-β-D-(4,2′′,4′′-triacetyl)-xylopyranoside (2a). Extracts, fractions, and isolated compounds were assessed for their antioxidant, urease, and α-glucosidase inhibitory activities. Compound 1 demonstrated potent antioxidant activity in the DPPH with an IC50 value of 36.4 ± 0.2 µM, while rhaponticin (3), 2,6-dimethoxybenzoquinone (4), and taraxerol (6) exhibited a strong α-glucosidase inhibitory activity with the IC50 values of 35.5 ± 0.1, 25.5 ± 0.2 and 43.4 ± 0.3 µM, respectively. The present study enriches the chemistry of Guiboutia ehie and provides further evidence on its bioactive constituents, which might help in the development of hypoglycaemic drugs.

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Section: Chemotaxonomic Significancementioning

confidence: 99%

Phytochemical compounds of Guibourtia ehie and their antioxidant, urease and α-glucosidase inhibitory activities

Bongmo¹,

Happi²,

Tabekoueng³

et al. 2022

NRFHH

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“…Leonard or giant false mopanie, is a tree native to southern Africa which can be found in Namibia, Zambia, Zaire, Zimbabwe and Angola also (Bekker et al, 2006). G. coleosperma aqueous and organic extracts both had moderate antimalarial activity, with IC 50 values of 31.61 and 28.17g/ml, respectively (du Preez et al, 2020).…”

Section: Leguminosaementioning

confidence: 99%

Prospective Plants with Corroborated Antimalarial Actions: A Review

et al. 2021

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Malaria is a serious illness resulted from parasites that are communicated to people through the bites of infected female Anopheles mosquitoes. Malaria is still in a worrying trend, particularly in tropical and subtropical climates although it is curable and preventable. In spite of a noteworthy abetment in incidence and death rates caused by malaria, even in 2017, a big number of people (219 million) have been affected by it along with 435 thousand confirmed death cases. Though a lot of synthetic drugs have been commercialized to treat malaria, those are compromised with some serious side effects. On the contrary, plant sources are always getting a big focus to develop novel and effective therapeutics in the treatment of different ailments i.e. quinine and artemisinin to treat malarial complications. The usage of herbal plants against malaria has also a very ancient root. Several families of plant species have showed potential antimalarial activities in previous research works. In this review work, families of these plants have been compiled so that prospective researchers can find a hint to discover more effective and safer plant-derived therapeutic options against malaria. Bangladesh Pharmaceutical Journal 24(2): 180-193, 2021

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Chemical Composition and Inhibitory Effects ofGuibourtia coleospermaagainst Plasmodium Parasites In Vitro

Cited by 2 publications

References 60 publications

Phytochemical compounds of <i>Guibourtia ehie</i> and their antioxidant, urease and α-glucosidase inhibitory activities

Phytochemical compounds of <i>Guibourtia ehie</i> and their antioxidant, urease and α-glucosidase inhibitory activities

Prospective Plants with Corroborated Antimalarial Actions: A Review

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