Chemical Composition and In Vitro Antioxidant Activity and Anti-Acetylcholinesterase Activity of Essential Oils from Tadehagi triquetrum (L.) Ohashi

Song, Wenzhi; Xu, Ziyue; Gao, Peizhong; Liu, Xu

doi:10.3390/molecules28062734

Cited by 5 publications

(3 citation statements)

References 42 publications

(49 reference statements)

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“…Prior research has shown the IC 50 values of A. annua and O. vulgare to be at 5.97 ± 0.51 mg/mL and 7.35 ± 0.30 mg/mL, respectively [ 55 , 56 ], suggesting their ABTS •+ free radical-scavenging activities are inferior to our essential oil. Nonetheless, other essential oils, such as S. rhombifolia and T. triquetrum , have demonstrated superior ABTS •+ -scavenging activities with IC 50 values of 1.47 ± 0.01 mg/mL [ 53 ] and 2.12 ± 0.05 mg/mL [ 54 ], indicating a more potent ability to neutralize free radicals. In the preceding experiments, the ABTS assay consistently demonstrated superior sensitivity in detecting free radical-scavenging activity compared to the DPPH assay.…”

Section: Resultsmentioning

confidence: 99%

“…The DPPH radical accepts electrons or hydrogen radicals from the donor compound and exhibits a strong absorption band at 515-520 nm [52]. At the highest concentration (10 mg/mL), the antioxidant activity of essential oil was 31.98%, whose potency seems weaker than those obtained from essential oils of other species [45,53,54].…”

Section: Antioxidant Activity Evaluationmentioning

confidence: 99%

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Spermacoce alata Aubl. Essential Oil: Chemical Composition, In Vitro Antioxidant Activity, and Inhibitory Effects of Acetylcholinesterase, α-Glucosidase and β-Lactamase

Zhu,

et al. 2024

Molecules

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Spermacoce alata Aubl. is widely available in the market as traditional Chinese medicine and animal feed, due to its properties of clearing heat and treating malaria and its high-protein and crude fiber content. In this study, the essential oil of S. alata was obtained through hydrodistillation. GC–MS and GC–FID methods were used to identify the chemical components and their relative abundance. Furthermore, the antioxidant capacity was measured using DPPH, ABTS, and FRAP assays, and the inhibitory effects of acetylcholinesterase, α-glucosidase, and β-lactamase were also evaluated. A total of 67 compounds were identified, with the major constituents being palmitic acid (30.74%), linoleic acid (16.13%), and phenylheptatriyne (8.07%). The essential oil exhibited moderate antioxidant activity against DPPH (IC50 > 10 mg/mL), while the IC50 value for the ABTS assay was 3.84 ± 2.12 mg/mL and the FRAP assay value was 87.22 ± 12.22 µM/g. Additionally, the essential oil showed moderate anti-acetylcholinesterase activity (IC50 = 286.0 ± 79.04 μg/mL), significant anti-α-glucosidase activity (IC50 = 174.7 ± 13.12 μg/mL), and potent anti-β-lactamase activity (IC50 = 37.56 ± 3.48 μg/mL). The results suggest that S. alata has the potential for application in pharmacology, warranting further exploration and investigation.

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Section: Resultsmentioning

confidence: 99%

Section: Antioxidant Activity Evaluationmentioning

confidence: 99%

Spermacoce alata Aubl. Essential Oil: Chemical Composition, In Vitro Antioxidant Activity, and Inhibitory Effects of Acetylcholinesterase, α-Glucosidase and β-Lactamase

Zhu,

et al. 2024

Molecules

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“…The percentages of inhibition of the oils were compared with the inhibition induced by the 1 mM Trolox solution. The total antioxidant capacity expressed in mg ET/mL of oil was calculated according to the equation proposed by [60,61]. Essential oils were tested without dilution.…”

Section: Antioxidant Potentialmentioning

confidence: 99%

Chemical Composition, Preliminary Toxicity, and Antioxidant Potential of Piper marginatum Sensu Lato Essential Oils and Molecular Modeling Study

et al. 2023

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The essential oils (OEs) of the leaves, stems, and spikes of P. marginatum were obtained by hydrodistillation, steam distillation, and simultaneous extraction. The chemical constituents were identified and quantified by GC/MS and GC-FID. The preliminary biological activity was determined by assessing the toxicity of the samples to Artemia salina Leach larvae and calculating the mortality rate and lethal concentration (LC50). The antioxidant activity of the EOs was determined by the DPPH radical scavenging method. Molecular modeling was performed using molecular docking and molecular dynamics, with acetylcholinesterase being the molecular target. The OES yields ranged from 1.49% to 1.83%. The EOs and aromatic constituents of P. marginatum are characterized by the high contents of (E)-isoosmorhizole (19.4–32.9%), 2-methoxy-4,5-methylenedioxypropiophenone (9.0–19.9%), isoosmorhizole (1.6–24.5%), and 2-methoxy-4,5-methylenedioxypropiophenone isomer (1.6–14.3%). The antioxidant potential was significant in the OE of the leaves and stems of P. marginatum extracted by SD in November (84.9 ± 4.0 mg TE·mL−1) and the OEs of the leaves extracted by HD in March (126.8 ± 12.3 mg TE·mL−1). Regarding the preliminary toxicity, the OEs of Pm-SD-L-St-Nov and Pm-HD-L-St-Nov had mortality higher than 80% in concentrations of 25 µg·mL−1. This in silico study on essential oils elucidated the potential mechanism of interaction of the main compounds, which may serve as a basis for advances in this line of research.

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Essential oil of Hygrophila salicifolia (Vahl) Nees: Chemical composition, evaluation of antioxidant activity, anti-acetylcholinesterase and anti-α-glucosidase activities integrating molecular docking, and network pharmacology analysis

Xu,

Zhu,

Zhao

et al. 2024

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Chemical Composition and In Vitro Antioxidant Activity and Anti-Acetylcholinesterase Activity of Essential Oils from Tadehagi triquetrum (L.) Ohashi

Cited by 5 publications

References 42 publications

Spermacoce alata Aubl. Essential Oil: Chemical Composition, In Vitro Antioxidant Activity, and Inhibitory Effects of Acetylcholinesterase, α-Glucosidase and β-Lactamase

Spermacoce alata Aubl. Essential Oil: Chemical Composition, In Vitro Antioxidant Activity, and Inhibitory Effects of Acetylcholinesterase, α-Glucosidase and β-Lactamase

Chemical Composition, Preliminary Toxicity, and Antioxidant Potential of Piper marginatum Sensu Lato Essential Oils and Molecular Modeling Study

Essential oil of Hygrophila salicifolia (Vahl) Nees: Chemical composition, evaluation of antioxidant activity, anti-acetylcholinesterase and anti-α-glucosidase activities integrating molecular docking, and network pharmacology analysis

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