Chemical composition and in vitro evaluation of antioxidant, antimicrobial, cytotoxicity and anti-acetylcholinesterase properties of Tunisian Origanum majorana L. essential oil

Hajlaoui, Hafedh; Mighri, Hédi; Aouni, Mahjoub; Gharsallah, Néji; Kadri, Adel

doi:10.1016/j.micpath.2016.03.003

Cited by 98 publications

(69 citation statements)

References 49 publications

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“…O. majorana EO content in monoterpene hydrocarbons (40.9%) and oxygenated monoterpenes (51.5%) was comparable to the results of Hajlaoui et al (2016) [22] while El Akhal et al 2014 Results obtained for R. officinalis EOs were in accordance with previous studies reporting that 1,8-cineole (37.6 and 47.2%), camphor (7.1 and 13.3%) and α-pinene (7.0 and 19.4%) were the major components of R. officinalis EO [43,44]while Verbenone (4.4-24.9%) was found to be the major component of R. officinalis EO from Corsica and Sardinia [45].…”

Section: Chemical Compositionsupporting

confidence: 74%

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Correlation between chemical composition and antibacterial activity of some Lamiaceae species essential oils from Tunisia

Moumni

Elaissi

Trabelsi

et al. 2020

BMC Complement Med Ther

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Background: Lamiaceae family is one of the most diverse and common plant families in terms of ethnomedicine due to their potential therapeutic effects. The aim of this study is to investigate the correlation between the chemical composition and the antibacterial effect of five essential oils from this family against five reference bacterial strains responsible of nosocomial diseases and foodborne illnesses. Methods: The commercial essential oils of Tunisian Rosmarinus officinalis, Thymus capitatus, Origanum majorana and Salvia officinalis were analyzed by GC/FID and GC-MS. Essential oils were evaluated for their antibacterial activities by disc diffusion and microbroth dilution methods against five reference bacterial strains: Pseudomonas aeruginosa, Escherichia coli, Salmonella enterica, Bacillus subtilis and Staphylococcus aureus. The inhibition zone diameter values and the twenty major compounds of the selected essential oils were subjected to PCA and HCA analysis. Results: Analysis by GC/FID and GC/MS allowed the identification of ninety-one components representing 96.0 to 98.2% of the total oils. The different component contents varied according to the species. The main components were carvacrol, 1,8-cineole, α-thujone, α-terpineol and α-pinene. The PCA and the HCA of the selected essential oil components and the inhibition zone diameter (IZD) values identified four species groups and subgroups. Each essential oils group constituted a chemotype responsible for their bacterial inhibition ability. Thymus capitatus essential oil showed the strongest antibacterial activity with MBC ranging from 0.73 to 2.94 mg mL − 1. Conclusion: Rosmarinus officinalis, Thymus capitatus, Origanum majorana and Salvia officinalis essential oils have shown promising antibacterial activities against reference bacterial strains responsible for nosocomial diseases and foodborne illnesses.

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Section: Chemical Compositionsupporting

confidence: 74%

“…O. majorana L. is used as a medicinal plant; it has traditionally been used as stimulant, condiment, and tonic [21]. In addition, O. majorana L. essential oil is used for its antibacterial [22] and antioxidant activities [21].…”

Section: Introductionmentioning

confidence: 99%

Correlation between chemical composition and antibacterial activity of some Lamiaceae species essential oils from Tunisia

Moumni

Elaissi

Trabelsi

et al. 2020

BMC Complement Med Ther

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“…Several studies have described that essential oils obtained from Origanum spp. show a wide range of biological activities, such as antifungal, antibacterial, antioxidant, antiinflammatory, insecticidal, cytotoxic and anti-acetylcholinesterase (Hajlaoui, Mighri, Aouni, Gharsallah, & Kadri, 2016;Revajová, Pistl, Levkut, Marcin, & Levkutová, 2010). In this sense, a supplementation of oregano essential oil increases proliferation of lymphocites, suggesting higher immune defense ability of the body (Revajová et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Herbicidal value of essential oils from oregano-like flavour species

Ibáñez

Blázquez

2017

Food and Agricultural Immunology

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Chemical composition and phytotoxicity of oregano, marjoram and Thymus mastichina essential oils against Portulaca oleracea L., Lolium multiflorum Lam. and Echinochloa crus-galli (L.) Beauv. has been investigated. Seventy-seven compounds reaching 97.3% and 99.4% were identified by gas chromatography-mass spectrometry. Carvacrol (60.42 ± 0.07%), p-cymene (15.52 ± 0.02%) and γterpinene (5.19 ± 0.02%) were the main compounds in oregano essential oil, whereas large amounts of 1,8-cineol (59.59 ± 0.85%, 49.49 ± 0.37%), linalool (13.05 ± 0.04%, 5.66 ± 0.01%) and αterpineol (3.36 ± 0.10%, 5.59 ± 0.01%), followed by β-pinene (4.35 ± 0.39, 5.54 ± 0.01%) and α-pinene (4.11 ± 0.53, 4.28 ± 0.01%) were found, respectively, in marjoram and T. mastichina essential oils. Oregano essential oil completely inhibited seed germination and seedling growth at all concentrations assayed (0.125-1 µL mL −1 ), whereas marjoram and T. mastichina essential oils only showed significant effects in hypocotyl and/or hypocotyl + radicle length depending on the weed and dose. ARTICLE HISTORY

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“…Lamiaceae species are known to contain a range of secondary metabolites, such as arbutin [22], tannins, flavonoids, sitosterol, phenolic glycosides, phenolic terpenoids [23], and numerous essential oil molecules [24]. HPLC analysis showed the presence of polyphenols and flavonoids in the organic fractions and the aqueous extract of Origanum majorana such as caffeic acid, chlorogenic acid, p -coumaric acid, trans -ferulic acid, cinnamic acid, quercetin, luteolin, apigenin, rutin, vanillic acid, syringic acid, o -coumaric acid, catechin, vanillin, trans -chalcone, 4-hydroxybenzoic acid, 2-(4-hydroxyphenyl)ethanol, and 3,4-dihydropyran.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of the Aqueous Extract and Organic Fractions from Origanum majorana on Human Breast Cell Line MDA-MB-231 and Human Colon Cell Line HT-29

Makrane

Messaoudi

Melhaoui

et al. 2018

Advances in Pharmacological Sciences

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The toxicity of the aqueous extract of Origanum majorana was tested (5 and 10 g/kg) in albino mice. No symptoms of toxicity or mortality were observed. The mice survived being active and healthy during all 14 days of observation. In addition, the weight measurement of the left and right kidneys, heart, and liver shows no significant difference between the control, 5 g/kg, and 10 g/kg. All extracts (aqueous, petroleum ether, dichloromethane, ethyl acetate, methanolic, and depleted aqueous extracts) of Origanum majorana tested against both types of cancer cells showed a more pronounced cytotoxic effect against breast cell line MDA-MB-231 than colon cells line HT-29 cells. The most marked effect is that of the ethyl acetate extract with IC50 30.90 ± 1.39 and 50.11 ± 1.44 (µg/ml), respectively. HPLC analysis of extracts from Origanum majorana showed that this plant contained polyphenols and flavonoids, which may be responsible for the biological activities found.

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Chemical composition and in vitro evaluation of antioxidant, antimicrobial, cytotoxicity and anti-acetylcholinesterase properties of Tunisian Origanum majorana L. essential oil

Cited by 98 publications

References 49 publications

Correlation between chemical composition and antibacterial activity of some Lamiaceae species essential oils from Tunisia

Correlation between chemical composition and antibacterial activity of some Lamiaceae species essential oils from Tunisia

Herbicidal value of essential oils from oregano-like flavour species

Cytotoxicity of the Aqueous Extract and Organic Fractions from Origanum majorana on Human Breast Cell Line MDA-MB-231 and Human Colon Cell Line HT-29

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