Chemical Composition and in-vitro Antimicrobial Activity of Leaf Essential Oils of Senecio pedunculatus Edgew. and Nepeta coerulescens Maxim

Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, and inflammation. In the current review, we discussed the emerging cellular and molecular mechanisms underlying therapeutic indications of chrysin in various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web of Science, and the search engine Google Scholar were searched for available and eligible research articles. The search was conducted by using MeSH terms and keywords in title, abstract, and keywords. In conclusion, experimental studies indicated that chrysin could ameliorate cancers of the breast, gastrointestinal tract, liver and hepatocytes, bladder, male and female reproductive systems, choroid, respiratory tract, thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, and lymph. However, more studies are needed to enhance the bioavailability of chrysin and evaluate this agent in clinical trial studies. Graphic abstract

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Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

Talebi

Farkhondeh

et al. 2021

Cancer Cell Int

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Chemical Composition and in-vitro Antimicrobial Activity of Leaf Essential Oils of Senecio pedunculatus Edgew. and Nepeta coerulescens Maxim

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Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

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