Chemical composition and<i>in vitro</i>antimicrobial activity of essential oil of<i>Rhynchosia heynei,</i>an endemic medicinal plant from Eastern Ghats of India

Bhakshu, Lepakshi Md.; Raju, R. R. Venkata

doi:10.3109/13880200902991573

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…There are no previous pharmacological studies on the antifungal activity of R. minima extracts. However, a few species in the Rhynchosia genus have been reported to possess varying degrees of antifungal activity against selected fungal strains [19,51,52] . Minimum Inhibitory Concentration (MIC) experiments of the extracts were carried out against C. albicans and C. neoformans .…”

Section: Resultsmentioning

confidence: 99%

“…However, a few species in the Rhynchosia genus have been reported to possess varying degrees of antifungal activity against selected fungal strains. [19,51,52] Minimum Inhibitory Concentration (MIC) experiments of the extracts were carried out against C. albicans and C. neoformans. According to Kuete, [53] plant extracts with MIC values lesser than 100 μg/mL are deemed significantly active, MIC values from 100 to 625 μg/mL are moderately active, while MIC values greater than 625 μg/mL exhibit a weak activity.…”

Section: Biological Activitymentioning

confidence: 99%

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Antifungal Compounds from the Leaves of Rhynchosia minima

Adewole

Famuyide

McGaw

et al. 2022

Chemistry & Biodiversity

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Rhynchosia minima, commonly known as jumby bean, is used as a remedy for respiratory ailments in various parts of the world. It is also used by South African traditional healers to treat heart or chest pain. This study aimed to investigate the bioactive constituents of the leaf extracts of R. minima against selected fungal isolates that have been identified as risk factors in respiratory illness. Rhynchosia minima leaves were extracted sequentially using hexane, dichloromethane, ethyl acetate and methanol in increasing order of polarity. The extracts were subjected to repeated chromatographic techniques, for phytochemical isolation. The extracts and isolated compounds were screened against Candida albicans and Cryptococcus neoformans by determining the minimum concentration that inhibited fungal growth. Six flavonoids, one norisoprenoid and one cyclitol were isolated and characterized by 1D and 2D NMR and HR‐ESI‐MS. The extracts obtained in the study had moderate to weak antifungal activities, with MICs ranging from 312.5 to 1250.0 μg/mL against both fungi. Four isolated compounds were also screened, with two of them exhibiting activity against C. albicans (MIC=6.25 μg/mL) that was comparable to amphotericin B, the positive control. These two compounds also had better antifungal potential against C. neoformans with an MIC=6.25 μg/mL, compared to the MIC of 12.5 μg/mL of amphotericin B. Seven of the eight isolated compounds were obtained from the extracts of Rhynchosia minima for the first time. Two of the isolated compounds demonstrated activity comparable or superior to amphotericin B activity. The notable potency displayed by these compounds warrants further investigation on their development as antifungal agents.

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Section: Resultsmentioning

confidence: 99%

Section: Biological Activitymentioning

confidence: 99%

Antifungal Compounds from the Leaves of Rhynchosia minima

Adewole

Famuyide

McGaw

et al. 2022

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…Likewise, the leaves of Rhynchosia beddomei were found to be antidiabetic (Mary et al 2014), Rhynchosia precatoria roots exhibits antimycobacterial activity (Coronado-Aceves et al 2017) and the Rhynchosia pyramidalis has androgenic and aphrodisiac action (Farnsworth et al 1967). The essential oil isolated from the leaves of Rhynchosia heynei and Rhynchosia minima showed broad spectrum of antimicrobial (Bakshu and Raju 2009;Gweru et al 2009), antioxidant activities (Gweru et al 2009) and allelopathy activity (Abd ElGawad et al 2018). Therefore, the development of drug agents from natural origin is of great importance, based on the traditional and pharmacological uses of the genus Rhynchosia.…”

Section: Traditional Usesmentioning

confidence: 99%