Chemical Composition and Cytotoxic Activity of the Fractionated Trunk Bark Essential Oil from Tetraclinis articulata (Vahl) Mast. Growing in Tunisia

Jlizi, Salma; Lahmar, Aida; Zardi‐Bergaoui, Afifa; Ascrizzi, Roberta; Flamini, Guido; Harrath, Abdel Halim; Chekir‐Ghedira, Leila; Jannet, Hichem Ben

doi:10.3390/molecules26041110

Cited by 10 publications

(9 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To overcome multidrug resistance in MDA-MB-231 breast cancer cells and investigate whether T. articulata essential oil possesses substantial in vitro cytotoxic properties ( Table 5 ). Jlizi et al (2021) tested the in vitro cytotoxic activity of T. articulata trunk bark essential oil against MDA-MB-231 breast cancer and SW620 colon cancer using the cell viability assay (MTT). They reported that the EO exhibited moderate dose-dependent cytotoxic potency against both cell lines.…”

Section: Biological Activities Of T Articulatamentioning

confidence: 99%

See 1 more Smart Citation

Tetraclinis articulata (vahl) masters: An insight into its ethnobotany, phytochemistry, toxicity, biocide and therapeutic merits

2022

View full text Add to dashboard Cite

Tetraclinis articulata (Vahl) Masters, commonly known as Sandarac tree and Araâr, is the only species representing the genus Tetraclinis Masters. The plant has been extensively used for medicinal, artistic, and ritual purposes since its first recorded use in 1800 B.C. Recently, a full range of ethnobotanical investigations has been undertaken to document the plant’s empirical knowledge. They reported the use of different parts, such as leaves, stems, cones, bark, and roots, as part of folk healing practices to manage diabetes mellitus, hypertension, fever, stomach disorders, and diarrhea, among others. The phytochemical studies have identified at least 130 compounds from leaves, cones, resin, bark, and woods. These chemical constituents are categorized into phenolic acids, flavonoids and their derivatives, volatile compounds, phytosterols, and fatty acids, among others. Furthermore, they have strongly been correlated with the promising antimicrobial, antioxidant, neuroprotective, antiurolithiatic, anti-inflammatory, antidiabetic, and cytotoxic properties of the plant. Toxicological studies argued that the plant is quite safe and devoid of eventual toxicity; however, in-depth investigations are required to validate the safety of the plant. The remarkable antimicrobial and antioxidant potencies of various extracts from the plant against a wide range of foodborne pathogens support their possible use to increase the shelf life of foodstuffs in the food industry. Likewise, various plant-based extracts have been proven to exert substantial biocidal properties, making them potential alternatives to synthetic pesticides in agriculture. The present review provides an up-to-date comprehensive insight about the ethnobotanical uses of T. articulata, along with its phytochemistry and biological activities to furnish directions for further studies. We also discussed the biocidal potency of the plant and highlighted its usage to extend the shelf life of perishable foods.

show abstract

Section: Biological Activities Of T Articulatamentioning

confidence: 99%

“…a cytotoxic effect against both cell lines MDA-MB-23, SW620, with IC50 values of 83.0 and 25.7 μg/ml, respectivelyJlizi et al (2021) …”

mentioning

confidence: 99%

Tetraclinis articulata (vahl) masters: An insight into its ethnobotany, phytochemistry, toxicity, biocide and therapeutic merits

2022

View full text Add to dashboard Cite

show abstract

“…), monoterpenes (e.g., limonene and carveol), and sesquiterpenes (e.g., β-caryophyllene and humulene) may participate in the cytotoxicity of the extract from the leaves of Tetraclinis articulata (Vahl) Mast. [28][29][30][31][32][33]. In summary, because patients with advanced cancers need selective anticancer drugs, we have searched for potential sources of selective anticancer drugs in a variety of plants.…”

Section: Resultsmentioning

confidence: 99%

Screening for Selective Anticancer Activity of 65 Extracts of Plants Collected in Western Andalusia, Spain

Calderón-Montaño

Martínez-Sánchez

Jiménez-González

et al. 2021

Plants

View full text Add to dashboard Cite

Finding cytotoxic drugs with a high selectivity towards cancer cells is crucial to improve the low survival rates of patients diagnosed with metastatic cancers. Since plants are an important source of anticancer drugs, we have screened 65 extracts from 45 plants collected in several areas of Western Andalusia (Spain) for cytotoxic activity on lung cancer cells versus lung normal cells. An extract from the leaves of Tetraclinis articulata (Vahl) Mast. (Cupressaceae) showed a marked cytotoxicity (IC50 = 0.37 ± 0.03 μg/mL) and selectivity (selectivity index = 378.3) against the lung cancer cells; cisplatin, 5-fluorouracil, and an extract from the leaves of Taxus baccata L. (Taxaceae) were less cytotoxic and selective. Extracts from Cascabela thevetia (L.) Lippold (Apocynaceae), Frangula alnus Mill. (Rhamnaceae), Iberis ciliata subsp. contracta (Pers.) Moreno (Brassicaceae), Juniperus macrocarpa Sm (Cupressaceae), and Pancratium maritimum L. (Amaryllidaceae) also showed selective cytotoxicity (selectivity index > 10). Active extracts were also tested against a panel of cancer cell lines from a variety tissues. The plants identified in this work are potential sources of natural compounds with selective toxicity towards cancer cells.

show abstract

“…In fact, essential oils are complex natural combination of volatile secondary metabolites, small molecular weight and lipophilic compounds [8] . They are known to exhibit various biological properties such as antimicrobial, [9] cytotoxic, [10] antioxidant, [11] anti‐inflammatory [12] and insecticidal [13] . Therefore, these volatile compounds could be a promising eco‐friendly alternative for controlling stored product insects [14] .…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Toxicity and Repellency ofInula graveolensEssential Oils from Roots and Aerial Parts against Stored‐Product BeetleTribolium castaneum(Herbst)

Mustapha

Algethami

Elamin

et al. 2023

Chemistry & Biodiversity

Self Cite

View full text Add to dashboard Cite

In this work, essential oils extracted from roots and aerial parts of Inula graveolens by hydrodistillation and their fractions obtained by chromatographic simplification were first investigated for their chemical composition by GC/MS and then evaluated for the first time for their repellency and contact toxicity properties against Tribolium castaneumadults. Twenty-eight compounds were identified in roots essential oil (REO), which accounted for 97.9 % of the total oil composition, with modhephen-8-β-ol (24.7 %), cis-arteannuic alcohol (14.8 %), neryl isovalerate (10.6 %) and thymol isobutyrate (8.5 %) as major constituents. Twenty-two compounds were found in the essential oil from aerial parts (APEO), which accounted for 93.9 % of the total oil, with borneol (28.8 %), caryophylla-4(14),8(15)-dien-6-ol (11.5 %), caryophyllene oxide (10.9 %), τ-cadinol (10.5 %) and bornyl acetate (9.4 %) as main compounds.REO and APEO displayed stronger repellency after 2 h of exposure (80.0 and 90.0 %, respectively) against T. castaneum at the concentration of 0.12 μL/cm 2 . After fractionation, fractions R 4 and R 5 exhibited greater effects (83.3 % and 93.3 %, respectively) than the roots essential oil. Furthermore, the fractions AP 2 and AP 3 showed higher repellency (93.3 and 96.6 %, respectively) than the aerial parts oil. The LD 50 values of oils from roots and aerial parts topically applied were 7.44 % and 4.88 %, respectively. Results from contact toxicity assay showed that fraction R 4 was more effective than the roots oil with LD 50 value of 6.65 %. These results suggests that essential oils of roots and aerial parts from I. graveolens may be explored as potential natural repellent and contact insecticides against T. castaneum in stored products.

show abstract

Chemical Composition and Cytotoxic Activity of the Fractionated Trunk Bark Essential Oil from Tetraclinis articulata (Vahl) Mast. Growing in Tunisia

Cited by 10 publications

References 28 publications

Tetraclinis articulata (vahl) masters: An insight into its ethnobotany, phytochemistry, toxicity, biocide and therapeutic merits

Tetraclinis articulata (vahl) masters: An insight into its ethnobotany, phytochemistry, toxicity, biocide and therapeutic merits

Screening for Selective Anticancer Activity of 65 Extracts of Plants Collected in Western Andalusia, Spain

Chemical Composition, Toxicity and Repellency ofInula graveolensEssential Oils from Roots and Aerial Parts against Stored‐Product BeetleTribolium castaneum(Herbst)

Contact Info

Product

Resources

About